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A BRET-based Mpro biosensor containing a nanobody and tandem cleavage sites shows an increased cleavage rate
منشور في 2025"…Further, mutational analysis revealed a requirement for both cleavage sites to be intact for increased cleavage rate. Importantly, the inclusion of an Mpro-binding, but non-inhibiting, NB2E3 nanobody at the N-terminal further increased the cleavage rate of the 2× cleavage sequence-containing Mpro biosensor. …"
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Total and segmental liver volume variations
منشور في 2015"…This reproducible, noninvasive procedure is necessary because significant interpatient variation is believed to exist in the relative contributions of the hepatic segments to TLV.11 CT volumetry accurately predicts TLV on the basis of body surface area or body weight,12 which may achieve the true goal of preoperative CT volumetry of the liver, that is to estimate the individual patient's hepatic metabolic demands after resection or transplantation.7 Complications associated with technical aspects of liver surgery are decreasing, and focus has concurrently shifted to analysis of postoperative complications after major hepatic resection and liver transplantation on the basis of liver remnant volume and graft volume.3., 4., 6., 7., 8. and 13. …"
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Interleukin-35 and Thymoquinone nanoparticle-based intervention for liver protection against paracetamol-induced liver injury in rats
منشور في 2023"…<p>Paracetamol (PAR) is a commonly used antipyretic and analgesic agent, but its excessive usage can induce liver damage and major health consequences. Interleukin-35 (IL-35) is utilized to treat immunological disorders, intestinal illness, arthritis, allergic disease, hepatitis, and cancer. …"
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A comparison of peer, teacher and self-feedback on the reduction of language errors in student essays
منشور في 2016"…However, comparison of students' performance on lexical errors at the immediate post-test revealed that the self-feedback group significantly decreased this error percentage compared to the peer feedback group. …"
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Resection of liver metastases from breast cancer
منشور في 2012"…On multivariate analysis, estrogen receptor–negative primary breast disease (P = .009; hazard ratio, 3.3; 95% confidence interval, 1.4–8.2) and preoperative progressive disease (P = .003; hazard ratio, 3.8; 95% confidence interval, 1.6–9.2) were associated with decreased overall survival. Conclusion Resection of breast cancer liver metastases in patients with estrogen receptor–positive disease that is responding to chemotherapy is associated with improved survival. …"
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Mitochondria-ER contact sites expand during mitosis
منشور في 2024"…<p dir="ltr">Mitochondria-ER contact sites (MERCS) are involved in energy homeostasis, redox and Ca<sup>2</sup>+ signaling, and inflammation. …"
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Coalition game theoretic P2P trading in a distribution network integrity-ensured local energy market
منشور في 2023"…This paper presents a peer-to-peer (P2P) trading-enabled local energy market (LEM) mechanism and analyses it in the Australian market context to verify its feasibility. …"
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Managing Procrastination on Social Networking Sites: The D-Crastinate Method
منشور في 2020"…Previous work has demonstrated the role of social networking site (SNS) design in users’ procrastination and revealed several types of procrastination on SNS. …"
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Seismic Site Response, Analysis and Characterization of Major Cities in UAE
منشور في 2011احصل على النص الكامل
doctoralThesis -
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Exendin-4 alleviates steatosis in an in vitro cell model by lowering FABP1 and FOXA1 expression via the Wnt/-catenin signaling pathway
منشور في 2022"…<p dir="ltr">Non-alcoholic fatty liver disease (NAFLD) is the leading chronic liver disease worldwide. …"
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One Dimensional Seismic Site Response Analysis of United Arab Emirates
منشور في 2021احصل على النص الكامل
doctoralThesis -
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Choice of specimen’s extraction site affects wound morbidity in laparoscopic colorectal cancer surgery
منشور في 2022"…The choice of incision for extraction site is an independent predicative factor for significantly higher IH and increased SSI rates.…"
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Integration of Wind Catchers in Modern Residential Buildings in the UAE as a Means of Providing Thermal Comfort
منشور في 2014"…This research is an evaluation of the effectiveness of wind catchers as means of providing thermal comfort for modern residential buildings in the hot arid climates in the UAE. …"
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Surgical Strategies for Synchronous Colorectal Liver Metastases in 156 Consecutive Patients
منشور في 2015"…Surgical resection of all tumor sites is the only treatment that enables prolonged survival, but the synchronous presentation of CLM has been associated with poor outcomes.1 Preoperative chemotherapy is widely used in these patients to provide early treatment of metastatic disease, to improve patient selection for surgical resection,2 and 3 and to decrease the recurrence rate after surgery.4 The traditional surgical strategy for patients with resectable synchronous CLM includes resection of the primary tumor followed by chemotherapy and then liver resection. …"
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Marine Bacterial Community Structures of Selected Coastal Seawater and Sediment Sites in Qatar
منشور في 2023"…In this work, we have utilized indicator bacteria such as total coliform, fecal coliform, and <i>Pseudomonas aeruginosa</i>, as well as 16S rRNA sequencing, to investigate the impact of environmental conditions and spatial variations on the diversity of bacterial communities in the coastal waters and sediments from selected sites in Qatar. The concentration levels of indicator bacteria were affected by increasing temperatures and pH, and by decreasing salinity of seawater samples. …"
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Chemotherapy prior to Hepatic Resection for Colorectal Liver Metastases: Helpful until Harmful?
منشور في 2009"…Bevacizumab can be used safely when discontinued >5 weeks before liver resection. Importantly, bevacizumab decreases the incidence and severity of sinusoidal injury with oxaliplatin therapy. …"
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Coevolving residues distant from the ligand binding site are involved in GAF domain function
منشور في 2025"…Here, we combine computational and experimental approaches to demonstrate that two highly coevolving residues, L267 and F295, distant from the ligand binding site, play a critical role in GAF domain allostery. …"