Inhibiting HSP90 changes the expression pattern of PINK1 and BNIP3 and induces oxidative stress in colon cancer cells by Ejlal Abu-El-Rub (5168183)

“…Similarly, genetic knockdown of HSP90 in RKO cells produced comparable effects, including reduced cell survival and a decreased PINK1/BNIP3 ratio.</p><h3>Conclusion</h3><p dir="ltr">Targeting HSP90 in colon cancer cells disrupts their survival by decreasing PINK1 and increasing BNIP3, which activates oxidative and endoplasmic reticulum stress, ultimately triggering apoptosis.…”

Old subjects with sepsis in the emergency department: trend analysis of case fatality rate by Andrea Fabbri (356760)

“…<h3>Background</h3><p dir="ltr">The burden of sepsis represents a global health care problem. …”

Prevalence of polypharmacy and the association with non-communicable diseases in Qatari elderly patients attending primary healthcare centers: A cross-sectional study by Ayman Al-Dahshan (8962568)

“…<h3>Background </h3><p dir="ltr">Polypharmacy has become a global public health concern particularly in the elderly population. …”

Correction: Prevalence of polypharmacy and the association with non-communicable diseases in Qatari elderly patients attending primary healthcare centers: A cross-sectional study by Ayman Al-Dahshan (8962568)

“…<p dir="ltr">Correction to: Prevalence of polypharmacy and the association with non-communicable diseases in Qatari elderly patients attending primary healthcare centers: A cross-sectional study. …”

Type 2 Diabetes Coagulopathy Proteins May Conflict With Biomarkers Reflective of COVID-19 Severity by Abu Saleh Md Moin (6189512)

“…</p><h3>Methods</h3><p dir="ltr">A prospective, parallel study in T2D (n = 23) and controls (n = 23). …”

The Effect of High Dose Isoflavone Supplementation on Serum Reverse T3 in Euthyroid Men With Type 2 Diabetes and Post-menopausal Women by Thozhukat Sathyapalan (704787)

“…<h3>Background</h3><p dir="ltr">The health benefits of soy are widely reported but there are queries on the effect of soy isoflavones on thyroid function and the underlying mechanism of action.…”

Trends in prevalence of blindness and distance and near vision impairment over 30 years: an analysis for the Global Burden of Disease Study by Rupert Bourne (603842)

“…<h3>Background</h3><p dir="ltr">To contribute to the WHO initiative, VISION 2020: The Right to Sight, an assessment of global vision impairment in 2020 and temporal change is needed. …”

A Modification to Enhance the Survival of the Island FDMA Flap by Adding a Skin Bridge by Salim Al Lahham (16515333)

“…</p><h3>Methods</h3><p dir="ltr">This is a case series that includes 9 patients where we describe a technique that has the potential to enhance the survival of the first dorsal metacarpal artery (FDMA) flap and decreases the rate of distal necrosis via addition of a 5-mm skin bridge to the pedicle and by avoiding tunneling. …”

Thalidomide-Revisited: Are COVID-19 Patients Going to Be the Latest Victims of Yet Another Theoretical Drug-Repurposing? by Athar Khalil (5906330)

“…Herein, we will discuss the theoretical effectiveness of Thalidomide in attenuating inflammatory complications that are encountered in COVID-19 patients while pinpointing the lack of the needed evidences to move forward with this drug.</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Immunology<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fimmu.2020.01248" target="_blank">https://dx.doi.org/10.3389/fimmu.2020.01248</a></p>…”

Factors Associated with Meeting Current Recommendation for Physical Activity in Scottish Adults with Diabetes by Ahmad Salman (3173418)

“…<p dir="ltr">It remains unclear which factors are instrumental in meeting the recommended physical activity in people with diabetes. …”

The cost-benefit associated with the maturity of the Antimicrobial Stewardship Program versus prematurity in Heart Hospital of Hamad Medical Corporation in Qatar by Dina Abushanab (10696501)

“…</p><h3>Conclusions</h3><p dir="ltr">M-ASP was associated with decreased operational and resource costs, but this was outweighed by increased costs of resistance and drug use, which could be due to higher sample size in the M-ASP. …”

Assessment of Knowledge, Attitude and Practice towards Sustainability Aspects among Higher Education Students in Qatar by Shaikha R. Al-Nuaimi (19488232)

“…<p dir="ltr">Sustainable development necessitates that societies design activities to meet human needs while protecting the planet’s life-support systems in consideration of depleting natural resources and concern for the state of the resources and climate. …”

Cost-benefit analysis of antimicrobial stewardship program in a cancer setting in Qatar by Dina Abushanab (10696501)

“…</p><h3>Methods</h3><p dir="ltr">We investigated the economic benefits of a premature versus a mature ASP from the perspective of a hospital. …”

Pore-scale simulation of fine particles migration in porous media using coupled CFD-DEM by Ahmed Elrahmani (17128837)

“…<p dir="ltr">Transport of fine particles in porous media has attracted a considerable interest over the past several decades given its importance to many industrial and natural processes. …”

Direct Oral Anticoagulants Compared to Warfarin in Patients with Intermediate‐ to High‐Risk Pulmonary Embolism: A Systematic Review and Meta‐Analysis by Mohamed Nabil Elshafei (9960500)

“…<h3>Introduction</h3><p dir="ltr">Despite recent advances in clinical therapeutics in patients with venous thromboembolism, uncertainty remains regarding the optimal anticoagulation strategy in patients with intermediate‐ to high‐risk pulmonary embolism. …”

Trends in prescribing and outcomes in obese versus non-obese patients receiving rivaroxaban therapy: an observational study using real-world data by Majdoleen Alalawneh (13961580)

“…<h3>Purpose</h3><p dir="ltr">To investigate real-world prescribing trends and clinical outcomes based on body mass index (BMI) categorization in patients who received rivaroxaban therapy.…”

Comparison of Burr-Hole Craniostomy versus Twist-Drill Craniostomy Operations for Patients with Chronic Subdural Hematoma: A Systematic Review and Network Meta-Analysis by Mohammed Maan Al-Salihi (13105835)

“…<h3>Background</h3><p dir="ltr">Chronic subdural hematoma (CSDH) represents one of the most common neurologic disorders in the elderly. …”

The immune landscape of solid pediatric tumors by Shimaa Sherif (12862990)

“…Upregulation of the WNT/Beta-catenin pathway was associated with unfavorable outcomes and decreased T-cell infiltration in OS.</p><h3>Conclusions</h3><p dir="ltr">We demonstrated that extracranial pediatric tumors could be classified according to their immune disposition, unveiling similarities with adults’ tumors. …”

Clinical characteristics and outcome of children with acute cryptorchid testicular torsion: A single-center, retrospective case series study by Zlatan Zvizdic (9212371)

“…<h3>Background</h3><p dir="ltr">Cryptorchidism and testicular torsion (TT) are relatively common conditions in clinical practice; however, sparse information about cryptorchid TT is available in the current literature.…”

Assessing the risk of angiotensin receptor blockers on major cardiovascular events: a systematic review and meta-analysis of randomized controlled trials by Yara Wanas (8744844)

“…<h3>Background</h3><p dir="ltr">Angiotensin receptor blockers (ARBs) are commonly used as a treatment for many cardiovascular diseases, but their safety has been called into question. …”