Small molecule inhibitors of α-synuclein oligomers identified by targeting early dopamine-mediated motor impairment in C. elegans حسب Kevin S. Chen (9201767)

"…<h3>Background</h3><p dir="ltr">Parkinson’s disease is a disabling neurodegenerative movement disorder characterized by dopaminergic neuron loss induced by α-synuclein oligomers. There is an urgent need for disease-modifying therapies for Parkinson’s disease, but drug discovery is challenged by lack of in vivo models that recapitulate early stages of neurodegeneration. …"

Global fertility in 204 countries and territories, 1950–2021, with forecasts to 2100: a comprehensive demographic analysis for the Global Burden of Disease Study 2021 حسب Natalia V, Bhattacharjee

"…Estimates and projections of fertility are necessary to inform policies involving resource and health-care needs, labour supply, education, gender equality, and family planning and support. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Optimal management, prevalence, and clinical behavior of saddle pulmonary embolism: A systematic review and meta-analysis حسب Fateen Ata (12217764)

"…Female sex (61.5 % vs. 41.3 %, p = 0.019), hypoxemia (90 % vs. 59.2 %, p < 0.001), massive PE features (89.7 % vs. 30.1 %, p < 0.001), associated chronic kidney disease (CKD) (10.3 % vs. 1.4 %, p = 0.002), and the need for mechanical ventilation (28.2 % vs. 13.1 %, p = 0.02) were significantly associated with increased mortality. …"

Prevalence and attributable health burden of chronic respiratory diseases, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 حسب Joan B Soriano (6458528)

"…However, when accounting for ageing and population growth, declines were observed in age-standardised prevalence (14·3% decrease), age-standardised death rates (42·6%), and age-standardised DALY rates (38·2%). …"

Human Recombinant Arginase I (Co)-PEG5000-Induced Arginine Depletion of Breast Cancer Cell Lines Causes Autophagy Mediated Cell Death حسب Alayan, Moustapha

"…In this study, we showed for the first time that arginine deprivation induced by a recombinant human arginase drug induces selective cytotoxicity mediated by autophagy in distinct human breast cancer cell lines. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Arginine Deprivation in AML Cells Induces Ferroptosis, a Type of Autophagy-Mediated Cell Death حسب Tohme, Sara

"…In this study, we showed for the first time that arginine deprivation using a recombinant human arginase induces ferroptosis, an autophagy-mediated type of cell death in AML cells. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Microwave-Assisted Solvothermal Synthesis of Mo-Doped TiO₂ with Exceptional Textural Properties and Superior Adsorption Kinetics حسب Yahia H. Ahmad (14340210)

"…The uniform effective heating delivered by microwave heating reduced the reaction time to less than 30 min, representing several orders of magnitude lower than conventional heating methods. …"

Cost-Benefit Analysis of Antimicrobial Stewardship Program in the Adult General Medicine Setting in Qatar حسب Dina Abushanab (10696501)

"…Operational costs included the monetary value of the time spent in data collection, clinical rounds, and committee meetings. …"

Biodegradable polysaccharide grafted polyacrylamide inhibitor for corrosion in CO₂- saturated saline solution حسب Rem Jalab (11715205)

"…Lastly, potentiostatic testing of steel with AGGPAM at an applied potential of 50 mV illustrated surface protection and decreased current over a prolonged time. Herein, the experimental investigation revealed the promising capabilities of AGGPAM as an efficient corrosion inhibitor in oilfields.…"

Removal of Benzene and Toluene from Synthetic Wastewater by Adsorption onto Magnetic Zeolitic Imidazole Framework Nanocomposites حسب George Z. Kyzas (740387)

"…Accordingly, the solution pH, Fe₃O₄@ZIF-8 dosage, mixing time, concentration of benzene and toluene, and temperature, were the parameters considered for conducting the batch experiments, for which their effect on adsorption efficiency was evaluated. …"

Meta-Heuristic Algorithm-Tuned Neural Network for Breast Cancer Diagnosis Using Ultrasound Images حسب Ahila A (18394806)

"…Early diagnosis is the only way to increase the treatment options which then decreases the death rate and increases the chance of survival in patients. …"

Fibrillar form of α-synuclein-specific scFv antibody inhibits α-synuclein seeds induced aggregation and toxicity حسب Vijay Gupta (209146)

"…In vitro studies indicated scFvs inhibit the seeding of α-syn aggregation in a time-dependent manner, decreased α-syn seed-induced toxicity in a cell model of PD, and reduced the production of insoluble α-syn phosphorylated at Ser-129 (pS129-α-syn). …"

Comparing WZB117-liposome Synthesis via Thin-film Hydration and Microfluidic Methods حسب Yaramiree, Atena

احصل على النص الكامل

Pavement Crack Assessment Using Satellite Remote Sensing and Deep Learning Model حسب Al Adab, Maryam

احصل على النص الكامل

Old subjects with sepsis in the emergency department: trend analysis of case fatality rate حسب Andrea Fabbri (356760)

"…Along the years CFR decreased from 31.8% (2009–2010) to 25.0% (2015–2016); P = 0.007. …"

Impact of trace noble metals on the catalytic performance of LaNiMgO towards methane dry reforming حسب Mohamed, Assem T.

"…On the other hand, at the same time-on-stream LaNiMgO-Rh lost 0.3 and 0.7 % of its maximum CO2 and CH4 conversions, respectively.In durability measurements, and after 140h LaNiMgO-Rh exhibited slight decay in the CO2 conversion from 77.6 % to 70.5%, the CH4 conversion decreased from 72.3% to 64.2%. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Mitigating the impact of cultural diversity on the innovation process in the private sector in Dubai حسب HAJI, HASSAN

"…The author further noted that cultural diversity has formed a paramount issue in business arena that need to be investigated to pave a clear way in order to accommodate people from various backgrounds. …"
احصل على النص الكامل

COVID-19 may have increased global support for universal health coverage: multi-country observational study حسب Claudia F. Nisa (11346055)

"…Trust in the government to deal with COVID-19 decreased over time, and this negative trajectory predicted a demand for better future government intervention in healthcare (ß = −0.10, <i>p</i> = 0.0003).…"

The Effect of EVA and TPU Custom Foot Orthoses on Running Economy, Running Mechanics, and Comfort حسب Ken Van Alsenoy (14150559)

"…Specific CFO-related running mechanical adjustments included a reduced braking impulse occurring in the first 25% of contact time with EVA, whereas wearing TPU increased propulsive loading rate.…"

Detailed organic characterization of process water to evaluate reverse osmosis membrane fouling in industrial wastewater treatment حسب Minier-Matar, Joel

احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل