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BCL-2 Inhibitor Venetoclax Induces Autophagy-Associated Cell Death, Cell Cycle Arrest, and Apoptosis in Human Breast Cancer Cells
Published 2020“…However, the mechanisms of anti-cancer effect of VCX either as a monotherapy or in combination with other chemotherapeutic agents against breast cancer need investigation.</p><h3>Methods</h3><p dir="ltr">Breast cancer cell lines with different molecular subtypes (MDA-MB-231, MCF7, and SKBR-3) were treated with different concentrations of VCX for indicated time points. …”
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Aqueous urtica dioica leaves extract inhibits proliferation of acute myeloid leukemia cells in vitro
Published 2017“…The decrease was more significant after 72hr with an IC50 at 16mg/ml. …”
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83
Sleeve Gastrectomy in Patients with Type 2 Diabetes: Anthropometric and Cardiometabolic Improvements at 1, 3, 5, 7, and 9 years—Are the Initial Benefits Sustained?
Published 2025“…Mean HbA1c significantly decreased from 8.1%preop to 6.77%<sub>year 9</sub>. …”
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84
Critical Review of Steel Column Base Plate Design Codes and Their Relevance to United Arab Emirates
Published 2019“…Structural engineers are often posed with a question for an economical design of a structural building which would decide the overall economic and the time concern in a construction. If the design is at optimum by choosing a suitable code the involvement of the materials would be less which will help to decrease the pollution caused in the environment as well. …”
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85
1787 evaluation of transperineal prostatic administration of a PSA-activasted protoxin (PRX302) in men with luts secondary to BPH
Published 2010“…In the Phase I study, mean IPSS showed a decrease of 6.5 points (34%), mean QoL a decrease of 2 points (44%) and mean prostate volume a decrease of 5.5 cc (13%) at 12-months compared to screening. …”
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86
Modification of glucocorticoid effects on body weight gain, plasma lipids by changes in diet composition
Published 2003“…All groups showed a decrease in relative intestinal absorption with time. …”
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87
Cdc42 is required for EGF-stimulated protrusion and motility in MTLn3 carcinoma cells
Published 2007“…When stimulated with EGF, carcinoma cells showed a rapid increase in activated Cdc42 that is primarily localized to the protruding edge of the cells. siRNA-mediated knockdown of Cdc42 expression caused a decrease in EGFstimulated protrusion and reduced cell motility in timelapse studies. …”
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88
Targeting the MAP kinase pathway in astrocytoma cells using a recombinant anthrax lethal toxin as a way to inhibit cell motility and invasion
Published 2016“…The cells also showed a decrease in invasion across a collagen matrix. The effect of LeTx on cell migration was mediated though the deregulation of Rho GTPases, which play a role in cell motility. …”
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Vocal Changes in Patients With Polycystic Ovary Syndrome
Published 2011“…There was no statistically significant difference in the acoustic parameters except for an increase in the relative average perturbation (P value = 0.035) and a decrease in maximum phonation time (P value = 0.001) in patients with PCOS. …”
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Cryomyolysis, a new procedure for the conservative treatment of uterine fibroids
Published 1998“…Normal uterine volume ranged from 35.6 to 548.7 ml preoperatively and 45.1 to 729.6 ml postoperatively (mean increase 40%); however, myoma volume showed a mean decrease of 6% (range-87-28%). …”
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91
Association Between Three-Months Vitamin D Supplementation and Depressive Symptomatology incidence among Saudi Arabian Adults
Published 2022“…The mean baseline 25(OH)D3 concentration was 16.92±7.23ng/ml in the vitamin D group and 16.44±5.91 ng/ml in the control group (p =0.76). …”
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92
The Effects of Local Aggregates on the Mechanical Properties of Engineered Cementitious Composites (ECC)
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93
Renal Function Decline in Recipients and Donors of Kidney Grafts
Published 2015“…Background/Aims: Renal function decreases over time as a result of reduction in the number of functioning nephrons with age. …”
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Aortic valve function post-replacement of severe aortic stenosis by transcatheter procedure versus surgery: a systematic review and metanalysis
Published 2021“…TAVR was associated with 37% (95% CI [0.51–0.78) mean RR reduction of post-procedural PPM, a decrease that was not affected by the surgical risk at inclusion, neither by the transcatheter heart valve system. …”
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Enhancing Security and Performance in Live VM Migration: A Machine Learning‐Driven Framework With Selective Encryption for Enhanced Security and Performance in Cloud Computing Envi...
Published 2025“…Rigorous experiments demonstrate its effectiveness, showcasing an average 51.82% reduction in downtime and an average 72.73% decrease in total migration time across diverse workloads. …”
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96
Redox Homeostasis and Inflammation Responses to Training in Adolescent Athletes: a Systematic Review and Meta-analysis
Published 2020“…Following more extended training periods, GSH showed moderate increases (ES 1.131; 95% CI 0.350 to 1.913;<i>Z</i>= 2.839,<i>p</i>= 0.005) while TBARS displayed a small decrease (ES 0.568; 95% CI − 0.062 to 1.197;<i>Z</i>= 1.768,<i>p</i>= 0.077). …”
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Drive‐up INR testing and phone‐based consultations service during COVID‐19 pandemic in a pharmacist‐lead anticoagulation clinic in Qatar: Monitoring, clinical, resource utilization...
Published 2023“…</p> <h3> Results</h3> <p>There was no statistically significant difference between clinic-based and phone-based anticoagulation services in mean time and number of visits within therapeutic range (<i>P</i> = .67; <i>P</i> = .06 respectively); mean number of extreme subtherapeutic and supratherapeutic INR values (<i>P</i> = .32 and <i>P</i> = .34, respectively); incidence of thromboembolic complications and warfarin related hospitalization. …”
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Predictors of prolonged hospitalization among geriatric trauma patients using the modified 5-Item Frailty index in a Middle Eastern trauma center: an 11-year retrospective study
Published 2025“…There was a significant decrease in the trend of geriatric trauma over the years. …”
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The contribution of autophagy in glioblastoma multiforme cells treated with human recombinant arginase I-induced arginine deprivation. (c2018)
Published 2018“…Furthermore, the contribution of autophagy to arginine depletion-induced cytotoxicity in GBM cells was tested by incubating SF and U87 cells with either HuArgI (Co)-PEG5000 alone and in combination with an autophagy inhibitor (chloroquine or 3- methyladenine) at different time points. Cell death decreased when autophagy was inhibited in SF cells at late time points, thus proving its role in arginine depletion induced cell death. …”
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