Inhibiting HSP90 changes the expression pattern of PINK1 and BNIP3 and induces oxidative stress in colon cancer cells by Ejlal Abu-El-Rub (5168183)

“…Similarly, genetic knockdown of HSP90 in RKO cells produced comparable effects, including reduced cell survival and a decreased PINK1/BNIP3 ratio.</p><h3>Conclusion</h3><p dir="ltr">Targeting HSP90 in colon cancer cells disrupts their survival by decreasing PINK1 and increasing BNIP3, which activates oxidative and endoplasmic reticulum stress, ultimately triggering apoptosis.…”

12/15-Lipoxygenase-Derived Lipid Metabolites Induce Retinal Endothelial Cell Barrier Dysfunction: Contribution of NADPH Oxidase by Amira Othman (380131)

“…Treatment of REC with HETE also increased ROS generation and expression of NOX2 and pVEGF-R2 and decreased pSHP1 expression. …”

Heat Shock-Related Protein Responses and Inflammatory Protein Changes Are Associated with Mild Prolonged Hypoglycemia by Abu Saleh Md Moin (6189512)

“…At hypoglycemia, UBE2N, STIP1, and UBE2L3 increased (all p < 0.05), whilst TLR4:MD-2 and HSPA8 decreased (p < 0.05) in T2D versus baseline. …”

Global, regional, and national burden of respiratory tract cancers and associated risk factors from 1990 to 2019: a systematic analysis for the Global Burden of Disease Study 2019 by Hedyeh Ebrahimi (7321358)

“…Global age-standardised incidence rates of tracheal, bronchus, and lung cancer decreased by 7·4% (−16·8 to 1·6) and age-standardised incidence rates of larynx cancer decreased by 3·0% (−10·5 to 5·0) in males over the past decade; however, during the same period, age-standardised incidence rates in females increased by 0·9% (−8·2 to 10·2) for tracheal, bronchus, and lung cancer and decreased by 0·5% (−8·4 to 8·1) for larynx cancer. …”

Engineering the Surface and Mechanical Properties of Water Desalination Membranes Using Ultralong Carbon Nanotubes by Yehia M. Manawi (18091207)

“…The water contact angle for PS membranes incorporated with commercial CNT sharply decreased from 73° to 53° (membrane hydrophilization) for membranes with 0.1 and 1.0 wt. % of CNTs, while for the same loading of produced CNTs the water contact angles for the membrane samples increased from 66° to 72°. …”

Hypertension as an Unusual Cause of Proliferative Retinopathy: Case Report and Literature Review by Rami Hasan Saleem Abu Sbeit (16444658)

“…This case further supports the presence of “proliferative hypertensive retinopathy” that needs to be identified and addressed urgently through collaboration between internists and ophthalmologists. …”

Modeling the risk-based decisions of the microgrid in day-ahead energy and reserve markets considering stochastic dispatching of electrical and thermal energy storages by Salah Bahramara (21347576)

“…Also, the risk-based behavior of the MGO showed that increasing the robust parameter decreases the reserve provided for the market and the net power trading with the market. …”

Glycolytic overload-driven dysfunction of periodontal ligament fibroblasts in high glucose concentration, corrected by glyoxalase 1 inducer by Amal Ashour (6752957)

“…</p><h3>Results</h3><p dir="ltr">In high glucose concentration cultures, there was a ca. twofold increase in cellular MG, cellular protein MG-H1 content and decreased attachment of PDLFs to collagen-I. …”

Genetic Variation in CCL5 Signaling Genes and Triple Negative Breast Cancer: Susceptibility and Prognosis Implications by Jingxuan Shan (4711089)

“…In the TCGA TNBC/Basal-like cohort the <b><i>MAP3K21</i></b><b> </b><b>rs1294255-G</b> allele was associated with a decreased OVS. High expression of <i>CCL5</i> in breast tumors was significantly associated with an increased OVS in all BC patients, but particularly in TNBC/Basal-like patients. …”

Old subjects with sepsis in the emergency department: trend analysis of case fatality rate by Andrea Fabbri (356760)

“…Along the years CFR decreased from 31.8% (2009–2010) to 25.0% (2015–2016); P = 0.007. …”

Effect of surfactants on the convective heat transfer and pressure drop characteristics of ZnO/DIW nanofluids: An experimental study by Adnan Qamar (14421759)

“…The viscosity (VC) and thermal conductivity (TC) of NFs exhibited a strong dependence on the operating temperature and NFs concentration. VC and TC increased by increasing the NFs concentration and decreased by increasing the operating temperature. …”

Hypertension in Childhood Nephrotic Syndrome by Ibrahim F. Shatat (14150601)

“…Children with NS are more likely to suffer from other cardiovascular disease risk factors, such as obesity, increased measures of arterial stiffness [increased carotid intima-media thickness (cIMT), endothelial dysfunction, increased pulse wave velocity (PWV)], impaired glucose metabolism, dyslipidemia, left ventricular hypertrophy (LVH), left ventricular dysfunction, and atherosclerosis. …”

Heart Rate Variability Analysis Reveals a Non-monotonic Relationship between Humanin Concentration and Cardiac Autonomic Regulation by Feng, Samuel

“…A mitohormetic type of relationship was observed with HRV features increasing and then decreasing with increasing HN concentration. …”
Get full text
Get full text

Effects of the addition of a high energy density fuel, adamantane to diesel on its cetane number, sooting propensity, and soot nanostructural properties by Al Zaabi, Alanood

“…The addition of up to 6.75 wt% of adamantane in diesel significantly increased the smoke point of diesel from 18 to 29 mm (and threshold sooting index decreased by 44%), indicating a drastic drop in fuel sooting tendency. …”
Get full text

Activation of the unfolded protein response in high glucose treated endothelial cells is mediated by methylglyoxal by Zehra Irshad (18614869)

“…Silencing of Glo1, selectively increasing MG, activated the UPR similarly. Silencing of HK-2 prevented increased glucose metabolism and MG formation. trans-Resveratrol and hesperetin combination (tRES-HESP) corrected increased MG and glucose metabolism by increasing expression of Glo1 and decreasing expression of HK-2. …”

دور مكاتب الإصلاح والوساطة والتوفيق الأسري في الأردن في الحد من النزاعات الأسرية من وجهة نظر العاملين بها... by Al-Oqaili , Amneh Irshied

Get full text

Essays on Renewable Energy Dynamics & Co₂ Emissions: Insights From Selected OIC Countries and World Nations by Javid Aliyev (19325665)

“…Based on the outcomes of the estimations, it was found out that government effectiveness, regulatory quality and renewable energy consumption has significant decreasing influence over CO₂ emissions, while GDP has increasing impact. …”

The global, regional, and national burden of colorectal cancer and its attributable risk factors in 195 countries and territories, 1990–2017: a systematic analysis for the Global B... by Saeid Safiri (3713035)

“…Although the overall colorectal cancer age-standardised death rate has been decreasing at the global level, the increasing age-standardised incidence rate in most countries poses a major public health challenge across the world. …”

The Economic Impact of Optimizing a COVID-19 Management Protocol in Pre-Existing Cardiovascular Disease Patients by Dina Abushanab (10696501)

“…<p>This study answers the question of whether the health care costs of managing COVID-19 in preexisting cardiovascular diseases (CVD) patients increased or decreased as a consequence of evidence-based efforts to optimize the initial COVID-19 management protocol in a CVD group of patients. …”

Epibenthic communities from offshore platforms in the Arabian Gulf are structured by platform age and depth by Felipe Torquato (14158845)

“…The lowest number of functional groups occurred in the early ages (2–3 years old), and some groups either increased or decreased their frequency and abundance along the years. …”