Harnessing the potential of CAR-T cell therapy: progress, challenges, and future directions in hematological and solid tumor treatments حسب Gunjan Dagar (9339276)

"…Despite success in blood cancers, CAR-T technology faces challenges in solid tumors, including lack of reliable tumor-associated antigens, hypoxic cores, immunosuppressive tumor environments, enhanced reactive oxygen species, and decreased T-cell infiltration. To overcome these challenges, current research aims to identify reliable tumor-associated antigens and develop cost-effective, tumor microenvironment-specific CAR-T cells. …"

Understanding the Mechanism of Diabetes Mellitus in LRBA-Deficient Patient حسب Iman Hawari (12561958)

"…</p><h3>Aims</h3><p dir="ltr">Our main objective is to study the molecular mechanism of diabetes mellitus in LRBA-deficient patient and to investigate if LRBA has any role in insulin biosynthesis and secretion in β pancreatic cells.…"

Prediction of critical total drawdown in sand production from gas wells: Machine learning approach حسب Fahd Saeed Alakbari (10701871)

"…Therefore, this study aims to build accurate and robust models for predicting CTD using response surface methodology (RSM) and support vector machine (SVM). …"

An efficient claim management assurance system using EPC contract based on improved monarch butterfly optimization models حسب K. Mukilan (22224793)

"…Among the prevalent issues in this sector, cash flow problems frequently lead to decreased productivity and efficiency. To address these challenges, a claim management system is developed based on the Improved Monarch Butterfly Optimization Algorithm (IMBOA) and the principles of EPC. …"

Effect of Mg incorporation on the properties of PCL/Mg composites for potential tissue engineering applications حسب Sumama Nuthana Kalva (19206064)

"…This study investigates the influence of Mg incorporation on the properties of PCL/Mg composites, aiming to evaluate their suitability for 3D-printable (3DP) tissue engineering applications. …"

Towards Industry 4.0 and Sustainable Manufacturing Applying Environmentally Friendly Machining of a Precipitation Hardened Stainless Steel Using Hot Turning Process حسب Mohammadjafar Hadad (17541345)

"…<p dir="ltr">This study aims to address the aforementioned challenges, solutions and implementation perspectives with regard to sustainable manufacturing. …"

High-sensitive detection and quantitation of thyroid-stimulating hormone (TSH) from capillary/fingerstick and venepuncture whole-blood using fluorescence-based rapid lateral flow i... حسب Samar, Shurbaji

"…To our knowledge, this is the first study to evaluate three different blood withdrawal techniques for evaluating POCT of TSH. AimWe aim to evaluate the performance of a new fluorescence-based LFIA and its Finecare™ fluorescent reader for quantitative measurement of TSH from a fingerstick, venepuncture whole-blood, and serum. …"
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3D printing of circular materials: Comparative environmental analysis of materials and construction techniques حسب Shoukat Alim Khan (14778226)

"…For each such innovation, it is essential to ensure its environmental sustainability at an early stage of development. This study aims to assess the potential environmental advantages and disadvantages of newly developed construction and demolition waste (CDW)-based geopolymer materials for 3D printing of built-environment structures. …"

Pore-scale simulation of fine particles migration in porous media using coupled CFD-DEM حسب Ahmed Elrahmani (17128837)

"…In order to control fine particles transport in porous media, the behavior itself needs to be predicted and analyzed. Which could be quite costly to do in a laboratory experiment, hence the modelling of such a behavior would be an optimum way to study. …"

Immunoprofile of childhood diabetes حسب Meritxell Espino-Guarch (15430868)

"…In order to be functional, the CD49d integrin needs to form a heterodimer with ITGB1 protein. When transcriptomic data was interrogated, an imbalance between ITGA4/ ITGB1 was observed in all groups where CD49d showed increased expression. …"

Comparison of Burr-Hole Craniostomy versus Twist-Drill Craniostomy Operations for Patients with Chronic Subdural Hematoma: A Systematic Review and Network Meta-Analysis حسب Mohammed Maan Al-Salihi (13105835)

"…We found that dBHC significantly decreased recurrence and reoperation rates compared with TDC (RR = 0.55, CI, 0.33–0.90 and RR = 0.48, CI, 0.24–0.94, respectively). …"

The promise of tirzepatide: A narrative review of metabolic benefits حسب Sara Sokary (17337724)

"…Tirzepatide also significantly decreased food intake, reduced overall appetite scores and increased fasting visual analog scale scores for satiety and fullness across different clinical trials. …"

Efficient Integration of Direct Air Capture With HVAC System حسب Yasser Mohamed Mohamed Taher Abdellatif (20741534)

"…Under humid conditions, replacing Lewatit with S-TEPA decreases thermal energy consumption from 425 kJ/molCO₂ to 325 kJ/molCO₂, and using S-PEI-L reduces it further to 275 kJ/molCO₂. …"

Assessing the risk of angiotensin receptor blockers on major cardiovascular events: a systematic review and meta-analysis of randomized controlled trials حسب Yara Wanas (8744844)

"…Risk of all-cause mortality and stroke decreased with ARB when the proportion of smokers in a population was < 25% (RR 0.91; 95%CI 0.84–0.98) and in females (RR 0.76; 95%CI 0.68–0.84), respectively.…"

Efficacy and safety of using Etelcalcetide for controlling secondary hyperparathyroidism حسب Tarek Fouda (18472476)

"…</p><h3>Results</h3><p dir="ltr">Patients within the PTH target range of 150 to 500pg/ml improved from 8% in June 2021 (on Cinacalcet) to 54% in June 2023 (on Etelcalcetide) (p=0 .0032) while patients with PTH above 1,000pg/ml decreased from 50% to 4% during the same period (p=0.00001) (Figure 2). …"

Evaluating the Successful Initiation of a New Dialysate Potassium Management Protocol: “Reduced Emergency Department Admission with Hyperkalemia in Hamad General Hospital Dialysis... حسب Shajahan Joseph K (18472465)

"…New guidelines for using various potassium buffer solution were proposed aiming to reduce the HD patient admission to the ED with hyperkalemia from 12% to <2% between January 2022 and January 2023, and to reduce the number of patients using low potassium buffer solution in the Dialysis units.…"

Understanding the phenomenon of saltwater intrusion sourced from desalination plants at coastal aquifers حسب Farhat Abbas (5480)

"…Modeling the trends of saltwater intrusion needs theoretical understanding and thorough logical experimentation. …"

Ratings of Perceived Exertion Misclassify Intensities for Sedentary Older Adults During Graded Cycling Test: Effect of Supramaximal High-Intensity Interval Training حسب Georges Jabbour (754884)

"…For both groups, RPE decreases with SCE at 10 min following graded test correlated significantly to V˙O₂ (r = 0.61, p < 0.01). …"

Essays on Digital Financial Inclusion and Financial Resilience for Sustainable Development in Sub-Saharan Africa حسب Jamila Abubakar (22653059)

"…A significant body of literature suggests the SSA’s middle class’s vulnerability to financial shocks, and our findings, indicating savings volatility and decreased savings accumulation due to financial shocks for the middle-income class groups, support these claims. …"

Glycolytic overload-driven dysfunction of periodontal ligament fibroblasts in high glucose concentration, corrected by glyoxalase 1 inducer حسب Amal Ashour (6752957)

"…</p><h3>Results</h3><p dir="ltr">In high glucose concentration cultures, there was a ca. twofold increase in cellular MG, cellular protein MG-H1 content and decreased attachment of PDLFs to collagen-I. This was driven by increased hexokinase-2 linked glucose metabolism and related increased MG formation. …"