Lactic acid mediates the effects of physical exercise on learning and memory through SIRT1-dependent activation of hippocampal BDNF. (c2018) حسب Hayek, Lauretta El

"…The action of lactate is dependent on the activation of the Sirtuin1 deacetylase. SIRT1 increases the levels of the transcriptional coactivator PGC1a and the secreted molecule FNDC5, previously shown to mediate Bdnf expression. …"
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The DJ-1 superfamily members YhbO and YajL from Escherichia coli repair proteins from glycation by methylglyoxal and glyoxal حسب Abdallah, Jad

"…YhbO and YajL belong to the PfpI/Hsp31/DJ-1 superfamily. Both proteins are involved in protection against environmental stresses. …"
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Exploring the Effect of [HuArgI (Co)-PEG5000]-Induced Autophagy on the Migration, Adhesion, and Invasion of A172 Glioblastoma Cells حسب Oneissi, Zeina

"…Our results show that arginine deprivation significantly activates autophagy in A172 cells, as evidenced by increased autophagosome formation and LC3-II/LC3-I ratios. …"
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Treatment with a Combination of Metformin and 2-Deoxyglucose Upregulates Thrombospondin-1 in Microvascular Endothelial Cells: Implications in Anti-Angiogenic Cancer Therapy حسب Samson Mathews Samuel (18808246)

"…We observed robust up-regulation of anti-angiogenic thrombospondin-1 (TSP1) and increased TSP1-CD36 co-localization with a marked decrease in the levels of phosphorylated vascular endothelial growth factor receptor-2 (pVEGFR2; Y1175) in 2DG (5 mM) exposed cells treated with metformin (2 mM). …"

Why wear a seat belt? I’m going to die anyway: Young Arab men’s rationales for deadly driving behaviors حسب Susan Dun (19807227)

"…We discovered that the perceived capability of actually changing one’s behavior is seriously impeded by a couple of characteristics our respondents shared and that they typically engage in quite risky driving behaviors. …"

Angiotensin II AT1 receptor internalization, translocation and de novo synthesis modulate cytosolic and nuclear calcium in human vascular smooth muscle cells حسب Sleiman, S.

"…This phenomenon of trancellular trafficking of receptors was associated with an increase of hAT1R. The Ang II induced increase of hAT1R density was prevented by the protein synthesis inhibitor cycloheximide. …"
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Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants حسب Bin, Zhou

"…By contrast, mean blood pressure might have increased in east and southeast Asia, south Asia, Oceania, and sub-Saharan Africa. …"
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10-Day structured initiation protocol from multiple daily injection to hybrid closed-loop system in children and adolescents with type 1 diabetes حسب Goran Petrovski (129836)

"…The participants used the sensor for a median of 92% of the time and spent a median of 89% in Auto Mode. The mean HbA1c decreased from 8.2 ± 1.4% (66 ± 15.3 mmol/mol) at baseline to 6.7 ± 0.5% (50 ± 5.5 mmol/mol) at the end of the study (p = 0.017). …"

The effect of online time on students’ academic performance: A study of cycle 1 and cycle 2 students in Abu Dhabi, UAE government schools حسب Sharabassy, Nermin Hamed

"…This growth is evident in the great increase of Internet use and the technological devices that have been invented and commonly used in a very short time. …"
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Yeast Lacking the PP2A Phosphatase Regulatory Subunit Rts1 Sensitizes rad51 Mutants to Specific DNA Damaging Agents حسب Mustapha Aouida (417652)

"…<i>RTS1</i> was among the genes that when singly deleted cause sensitivity to bleomycin. …"

Cytotoxicity of Anthrax Lethal Toxin to Human Acute Myeloid Leukemia Cells Is Nonapoptotic and Dependent on Extracellular Signal-Regulated Kinase 1/2 Activity حسب Abi-Habib, Ralph J.

"…Flow cytometry analysis of MAPK pathway activation revealed the presence of phospho-ERK1/2 only in LeTx-sensitive cells. Staining for Annexin V/propidium iodide and active caspases showed an increase in double-positive cells and the absence of caspase activation following treatment, indicating that LeTx-induced cell death is caspase-independent and nonapoptotic. …"
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Sesamum indicum (sesame) enhances NK anti-cancer activity, modulates Th1/Th2 balance, and suppresses macrophage inflammatory response حسب Majdalawieh, Amin

"…Moreover, Sesamum indicum increased the cytotoxic activity of NK cells against YAC-1 tumor cells. …"
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Clinical patterns and outcomes of hospitalized patients with grinder-related neurovascular injuries: A decade of experience from a Level I Trauma center حسب Hassan Al-Thani (440106)

"…The majority were general laborers (66.1 %), injured by portable grinders (86.6 %), and direct blade contact (64.6 %). …"

Water-pipe smoking promotes epithelial–mesenchymal transition and invasion of human breast cancer cells via ERK1/ERK2 pathways حسب Khaled W. Sadek (14153196)

"…<p>With the increasing popularity of water-pipe smoking (WPS), it is critical to comprehend how WPS may affect women’s health. …"

PD-L1 Blockade by Atezolizumab Downregulates Signaling Pathways Associated with Tumor Growth, Metastasis, and Hypoxia in Human Triple Negative Breast Cancer حسب Reem Saleh (3513056)

"…Targeting programmed cell death-ligand 1 (PD-L1) by monoclonal antibodies (mAbs), for example, atezolizumab, has revolutionized the treatment for various cancer types. …"

The predictive value of CTSI scoring system in non-operative management of patients with splenic blunt trauma: The experience of a level 1 trauma center حسب Ali Barah (14777533)

"…<h3>Background</h3><p dir="ltr">The spleen is one of the most injured organs following blunt abdominal trauma. …"

Improved quality of 1H NMR spectroscopic data for enhanced metabolic profiling of low molecular weight metabolites in human serum Authors Authors and affiliations حسب Stolzenburg, Svenja

"…An OPLS model of fasting blood glucose showed an increase of Q2 when using spectra from ultrafiltrated serum (Q2 = 0.261) compared to using CPMG spectra (Q2 = 0.173). …"
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Long-Chain Acyl-CoA Synthetase 1 Role in Sepsis and Immunity: Perspectives From a Parallel Review of Public Transcriptome Datasets and of the Literature حسب Jessica Roelands (7516439)

"…Participants first assessed the robustness of the potential gap in biomedical knowledge identified via an initial screen of public transcriptome data and of the literature associated with ACSL1. Increase in ACSL1 transcript abundance during sepsis was confirmed in several independent datasets. …"

Studies of Glyoxalase 1-Linked Multidrug Resistance Reveal Glycolysis-Derived Reactive Metabolite, Methylglyoxal, Is a Common Contributor in Cancer Chemotherapy Targeting the Splic... حسب Muhanad Alhujaily (11630107)

"…Antitumor drugs increased MG to cytotoxic levels which contributed to the cytotoxic, antiproliferative mechanism of action, consistent with Glo1-mediated MDR. …"

Photoactivatable RuII Complex Bearing 2,9‐Diphenyl‐1,10‐phenanthroline: Unusual Photochemistry and Significant Potency on Cisplatin‐Resistant Cell Lines حسب Mansour, Najwa

"…In conclusion, the Ru‐centered complex 1 could represent a potential photoactivatable chemotherapeutic drug that increases selectivity to tumors and offers alternative treatment in the light of increasing cisplatin resistance.…"
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