The carboxy terminal coiled-coil modulates Orai1 internalization during meiosis حسب Rawad Hodeify (9592365)

"…SOCE is tightly regulated during meiosis, including internalization of the SOCE channel, Orai1. Orai1 is a four-pass membrane protein with cytosolic N- and C-termini. …"

Editorial: Dynamic Biomarkers of Response to Anti-Immune Checkpoint Inhibitors in Cancer حسب Said Dermime (79420)

"…In current clinical practice only PD-L1 expression in tumor tissues is used as predictive biomarker of response to PD-1 immune checkpoint blockade. …"

Guanine glycation repair by DJ-1/Park7 and its bacterial homologs حسب Richarme, Gilbert

"…DJ-1–depleted cells displayed increased levels of glycated DNA, DNA strand breaks, and phosphorylated p53. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Stimulation of sphingosine 1-phosphate signaling as an alveolar cell survival strategy in emphysema حسب Diab, Khalil J.

"…The effects of increased endogenous ceramides could be offset by sphingosine 1-phosphate (S1P), a prosurvival by-product of ceramide metabolism. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Higher serum leptin level in women than in nen with type 1 diabetes حسب Azar, Sami T.

"…In humans, serum leptin concentrations are increased in relation to increased body fat content. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions حسب Murali K. Akula (9389280)

"…Consistently, inactivating Iqgap1 normalizes Rac1 GTP-loading, and reduces inflammation and arthritis in GGTase-I-deficient mice, as well as prevents statins from increasing Rac1 GTP-loading and cytokine production in macrophages. …"

A decoding algorithm for I-Q space-time coded systems in fadingenvironments حسب Zummo, S.A.

"…This paper presents the decoding of the I-Q space-time (ST) codes. The decoding problem of I-Q ST codes is formulated. …"
احصل على النص الكامل
احصل على النص الكامل

DUSP1 Is a Potential Marker of Chronic Inflammation in Arabs with Cardiovascular Diseases حسب Abdelkrim Khadir (437074)

"…Multivariate logistic regression analysis showed that DUSP1 and hsCRP are independently associated with CVD in the studied population, as reflected by 2-fold and 1.5-fold increased risks with increased levels of DUSP1 and hsCRP, respectively. …"

The Effect of HuArgI (Co)-PEG5000 on The Migration of Ovarian Cancer حسب El Mais, Nour

"…In this study, we hypothesized that HuArgI (Co)- PEG5000 can decrease the migration of ovarian cancer cells. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

The effect of GLP-1R agonists on the medical triad of obesity, diabetes, and cancer حسب Shahad Sabaawi Ibrahim (21842273)

"…While other GLP-1R agonists have shown promising outcomes in mitigating cancer progression, the association between some GLP-1R agonists and an increased risk of cancer remains a topic requiring more profound investigation. …"

Challenges for road safety in fast developing societies: We need a vision zero to permanently reduce accidents and save life and health by facing fast increasing traffic حسب Kurt Bodewig (19794543)

Circulating exosomal immuno-oncological checkpoints and cytokines are potential biomarkers to monitor tumor response to anti-PD-1/PD-L1 therapy in non-small cell lung cancer patien... حسب Shayista Akbar (14442117)

"…Non-responding patients showed a significant increase in exosomal-PD-L1 (p=0.0078). Furthermore, responding-patients without liver-metastasis showed significant-upregulation of PD-1 (p=0.0070), and downregulation of ULBP1 (p=0.0137) and Siglec-7 (p=0.0037). …"

Do Private Schools in Abu Dhabi UAE foster critical thinking as one of the main objectives of education? حسب SAAD, GEORGE JEAN

احصل على النص الكامل

Flexural strengthening of one-way reinforced concrete slabs using near surface-mounted BFRP bars حسب Omar Aljidda (17823488)

"…<p>This study examines the flexural behavior of reinforced concrete (RC) one-way slabs strengthened with near-surface mounted (NSM) basalt fiber-reinforced polymer (BFRP) bars. …"

Pregnant Women's experiences with intimate partner violence one year after the COVID‐19 pandemic in Jordan حسب Sanaa Abujilban (12106945)

"…There were statistically significant (<i>p </i>≤ 0.05) higher mean DVQST scores for control IPV and psychological IPV during the pandemic (control IPV mean = 9.78, psychological mean = 7.03) versus before the pandemic (control IPV mean = 8.95, psychological mean = 6.62). …"

Regulation of the aryl hydrocarbon receptor in cancer and cancer stem cells of gynecological malignancies: An update on signaling pathways حسب Lubna Therachiyil (4246156)

"…One of the important pathways that mediates the metabolism and bioactivation of these environmental chemicals is the transcription factor, aryl hydrocarbon receptor (AhR). …"

Evaluation of the mode I plastic zone size at the crack tip using RKPM and FEM حسب Abi Shdid, Caesar

"…In this study, it is proposed to obtain the mode I plastic zone size and shape at the crack-tip in a work-hardening material using RKPM. …"
احصل على النص الكامل
احصل على النص الكامل

Combined Noncoding RNA-mRNA Regulomics Signature in Reprogramming and Pluripotency in iPSCs حسب Salam Salloum-Asfar (656363)

"…Introducing miRNAs, such as miR-294 and miR302/3667, with reprogramming factors, has shown to increase iPSC colony formation. Previously, we identified five transcription factors, GBX2, NANOGP8, SP8, PEG3, and ZIC1, which may boost iPSC generation. …"

IL-1 stimulates ceramide accumulation without inducing apoptosis in intestinal epithelial cells حسب Homaidan, Fadia R.

"…Background: In inflammatory bowel disease (IBD), cytokine levels (such as interleukin-1 (IL-1)) are elevated. We have shown previously that IL-1 activates phospholipid signaling pathways in intestinal epithelial cells (IEC), leading to increased ceramide levels. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Kefir induces cell-cycle arrest and apoptosis in HTLV-1-negative malignant T-lymphocytes حسب Rizk, Sandra

"…Purpose: The present study investigates the effect of a cell-free fraction of kefir on CEM and Jurkat cells, which are human T-lymphotropic virus type I (HTLV-1)-negative malignant T-lymphocytes. Methods: Cells were incubated with different kefir concentrations. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل