Neoadjuvant Chemotherapy Alters Neuropilin-1, PlGF, and SNAI1 Expression Levels and Predicts Breast Cancer Patients Response حسب Noura Al-Zeheimi (5177066)

"…These observations support the need to consider anti-NRP-1 as a potential targeted therapy for breast cancer patients who are identified with high NRP-1 levels. …"

Small molecule inhibitors of α-synuclein oligomers identified by targeting early dopamine-mediated motor impairment in C. elegans حسب Kevin S. Chen (9201767)

"…<h3>Background</h3><p dir="ltr">Parkinson’s disease is a disabling neurodegenerative movement disorder characterized by dopaminergic neuron loss induced by α-synuclein oligomers. There is an urgent need for disease-modifying therapies for Parkinson’s disease, but drug discovery is challenged by lack of in vivo models that recapitulate early stages of neurodegeneration. …"

Optimal management, prevalence, and clinical behavior of saddle pulmonary embolism: A systematic review and meta-analysis حسب Fateen Ata (12217764)

"…Female sex (61.5 % vs. 41.3 %, p = 0.019), hypoxemia (90 % vs. 59.2 %, p < 0.001), massive PE features (89.7 % vs. 30.1 %, p < 0.001), associated chronic kidney disease (CKD) (10.3 % vs. 1.4 %, p = 0.002), and the need for mechanical ventilation (28.2 % vs. 13.1 %, p = 0.02) were significantly associated with increased mortality. …"

Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 co... حسب Alize J, Ferrari

"…Globally between 2010 and 2021, the age-standardised DALY rates for HIV/AIDS decreased by 47·8% (43·3–51·7) and for diarrhoeal diseases decreased by 47·0% (39·9–52·9). …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Mitigating the impact of cultural diversity on the innovation process in the private sector in Dubai حسب HAJI, HASSAN

"…The author further noted that cultural diversity has formed a paramount issue in business arena that need to be investigated to pave a clear way in order to accommodate people from various backgrounds. …"
احصل على النص الكامل

The burden of unintentional drowning: global, regional and national estimates of mortality from the Global Burden of Disease 2017 Study حسب Richard Charles Franklin (9154052)

"…The results reinforce the need for continued and improved policy, prevention and research efforts, with a focus on low- and middle-income countries.…"

Burden of disease scenarios for 204 countries and territories, 2022–2050: a forecasting analysis for the Global Burden of Disease Study 2021 حسب Stein Emil, Vollset

"…In the assessment of alternative future scenarios, the combined effects of the scenarios (Safer Environment, Improved Childhood Nutrition and Vaccination, and Improved Behavioural and Metabolic Risks scenarios) demonstrated an important decrease in the global burden of DALYs in 2050 of 15·4% (13·5–17·5) compared with the reference scenario, with decreases across super-regions ranging from 10·4% (9·7–11·3) in the high-income super-region to 23·9% (20·7–27·3) in north Africa and the Middle East. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Global, regional, and national burden of stroke and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019 حسب Valery L Feigin (5320574)

"…During the same period, age-standardised rates of stroke incidence decreased by 17·0% (15·0–18·0), mortality decreased by 36·0% (31·0–42·0), prevalence decreased by 6·0% (5·0–7·0), and DALYs decreased by 36·0% (31·0–42·0). …"

Global, regional, and national mortality among young people aged 10–24 years, 1950–2019: a systematic analysis for the Global Burden of Disease Study 2019 حسب Joseph L Ward (9715619)

"…Since 1950, deaths in this age group decreased by 30·0% in females and 15·3% in males, and sex-based differences in mortality rate have widened in most regions of the world. …"

Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950–2019: a comprehensive demographic anal... حسب Haidong, Wang

"…Uncertainty was propagated throughout the demographic estimation process, including fertility, mortality, and population, with 1000 draw-level estimates produced for each metric. FindingsThe global TFR decreased from 2·72 (95% uncertainty interval [UI] 2·66–2·79) in 2000 to 2·31 (2·17–2·46) in 2019. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

A Case Study in Qatar for Optimal Energy Management of an Autonomous Electric Vehicle Fast Charging Station with Multiple Renewable Energy and Storage Systems حسب Abdulla Al Wahedi (17115613)

"…This interest has focused mainly on reducing the reliance on fossil fuel-based means of transportation and decreasing the harmful emissions produced from this sector. …"

Global, regional, and national progress towards Sustainable Development Goal 3.2 for neonatal and child health: all-cause and cause-specific mortality findings from the Global Burd... حسب Katherine R Paulson (8674293)

"…Optimal child survival metrics were developed by age, sex, and cause of death across all GBD location-years. …"

Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950–2019: a comprehensive demographic anal... حسب Haidong Wang (47381)

"…Uncertainty was propagated throughout the demographic estimation process, including fertility, mortality, and population, with 1000 draw-level estimates produced for each metric. Findings The global TFR decreased from 2·72 (95% uncertainty interval [UI] 2·66–2·79) in 2000 to 2·31 (2·17–2·46) in 2019. …"

Open carbon frameworks - a search for optimal geometry for hydrogen storage حسب Kuchta, Bogdan

"…From an analysis of an analytical model and simulations of adsorption the physical limits of hydrogen adsorption have been defined: (i) higher storage capacities in slit-shaped pores can be obtained by fragmentation/truncation of graphene sheets into nano-metric elements which creates surface areas in excess of 2600 m2/g, the surface area for infinite graphene sheets; (ii) the positive influence of increasing surface area is compensated by the decreasing energy of adsorption in the carbon scaffolds of nano-metric sizes; (iii) for open carbon frameworks (OCF) built from coronene and benzene molecules with surface areas 6500 m2 g-1, we find an impressive excess adsorption of 75–110 g H2/kg C at 77 K, and high storage capacity of 110–150 g H2/kg C at 77 K and 100 bar; (iv) the new OCF, if synthesized and optimized, could lead to required hydrogen storage capacity for mobile applications.…"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Effect of Intravenous Mannitol on Intraocular Pressure Changes in Vitrectomized and Non-Vitrectomized Eyes: A Systematic Review and Meta-Analysis حسب HASHEM ABU SERHAN (19737499)

"…In vitrectomized eyes, notable decreases were observed: at 30 min, the Ratio of Means (ROM) was 0.81 (95% CI: 0.53; 1.24), indicating a 19% reduction; at 60 min, the ROM of 0.833 (95% CI: 0.77; 0.89) showed a 16.7% reduction; at 90 min, the ROM of 0.757 (95% CI: 0.755; 0.758) corresponded to a 24.3% reduction; at 2 h, the ROM of 0.726 (95% CI: 0.642; 0.820) reflected a 27.4% reduction; at 3 h, the ROM of 0.692 (95% CI: 0.600; 0.797) resulted in a 30.8% reduction; and at 4 h, the ROM of 0.700 (95% CI: 0.363; 1.350) indicated a 30% reduction. …"

Machine Learning Models for Scheduling On-Demand Fog Placement and Optimizing Container Deployment حسب Farhat, Peter

"…Second, we propose a K-Means based clustering model embedded within a multi-objective optimization scheme for fog and container placement. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Sustainable energy-water-food nexus integration and optimisation in eco-industrial parks حسب Jamileh Fouladi (16932549)

"…Furthermore, a sustainability metric is applied to compute the effect of each scenario on EWF resources. …"

Enhanced PSO-Based NN for Failures Detection in Uncertain Wind Energy Systems حسب Khaled Dhibi (16891524)

"…Then, in order to maximize the diversity between data samples and improve the effectiveness of using PSO algorithm for feature selection, the Euclidean distance metric is used in order to reduce the data and maximize the diversity between data samples. …"

Mapping geographical inequalities in access to drinking water and sanitation facilities in low-income and middle-income countries, 2000–17 حسب Aniruddha Deshpande (4377094)

"…Interpretation Our estimates, combined with geospatial trends in diarrhoeal burden, identify where efforts to increase access to safe drinking water and sanitation facilities are most needed. By highlighting areas with successful approaches or in need of targeted interventions, our estimates can enable precision public health to effectively progress towards universal access to safe water and sanitation. …"

Efficiency of Azithromycin-Loaded Lipid Polymer Hybrid Nano-vehicle as a Repurposing formulation in Colon Cancer Management حسب Tarraf, Vanessa

"…The results displayed Nano metric size range for azithromycin-loaded uncoated and coated liposomes of values 65.5± 2.83 nm and 73.53 ± 2.01 nm, respectively with uni-modal particle size distribution with PDI less than 0.3. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل