Alterations in Beta Cell Identity in Type 1 and Type 2 Diabetes حسب Abu Saleh Md Moin (6189512)

"…Dedifferentiation is well characterized by the decrease in expression of key β cell markers such as genes encoding major transcription factors, e.g., MafA, NeuroD1, Nkx6.1, and Foxo1, and an increase in atypical or “disallowed” genes for β cells such as lactate dehydrogenase, monocarboxylate transporter MCT1, or progenitor cell genes (Neurog3, Pax4, or Sox9). …"

miRNA-dependent regulation of STIM1 expression in breast cancer حسب Rashmi P. Kulkarni (18618634)

"…Consistently, overexpression of Ago2 results in decreased STIM1 protein levels in MDA-MB-231 cells. …"

Post-transcriptional regulation of Pabpn1 by the RNA binding protein HuR حسب Brittany L Phillips (18696937)

"…We exploit multiple models including C2C12 myotubes, primary muscle cells, and mice to determine that HuR decreases Pabpn1 expression. Overall, we have uncovered a mechanism in mature muscle that negatively regulates Pabpn1 expression in vitro and in vivo, which could provide insight to future studies investigating therapeutic strategies for OPMD treatment.…"

Design and analysis of PV fed high-voltage gain DC-DC converter using PI and NN controllers حسب Madisa V.G., Varaprasad

"…The modified converter contains mainly-one diode, two capacitors, and Coupled Inductor (CI). …"
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The effect of advanced hybrid closed loop system on glycated hemoglobin (HbA1c) in a young male with type 1 diabetes mellitus and growth hormone treatment: A case report حسب Goran Petrovski (129836)

"…<p dir="ltr">The advanced hybrid closed loop system MiniMed 780G can be an effective tool to improve glycemic control and decrease the health burden in a young male with type 1 diabetes and short stature.…"

Efficacy and safety of the newer oral hypoglycemic agents in patients with T2DM during Ramadan: A systematic review and meta-analysis حسب Hoda Gad (6470522)

"…Dipeptidyl peptidase-4 inhibitors (DPP-4i) led to a significant reduction in Hb_A1c (%) (SMD -0.25) and a non-significant decrease in weight (kg) (SMD -1.06) during Ramadan. …"

Combined Noncoding RNA-mRNA Regulomics Signature in Reprogramming and Pluripotency in iPSCs حسب Salam Salloum-Asfar (656363)

"…Introducing miRNAs, such as miR-294 and miR302/3667, with reprogramming factors, has shown to increase iPSC colony formation. Previously, we identified five transcription factors, GBX2, NANOGP8, SP8, PEG3, and ZIC1, which may boost iPSC generation. …"

Long non-coding RNA MALAT1 promotes steatosis in HepG2 cells by modulating target gene expression in presence of Exendin-4 حسب Olfa Khalifa (10914452)

"…Furthermore, confocal microscopy analysis of BODIPY-stained untreated, steatotic, and Ex-4-treated steatotic cells showed that Ex-4 significantly decreases the number of lipid droplets. Fatty acid uptake and transport genes were also affected by MALAT1 knockdown. …"

Intelligent route to design efficient CO₂ reduction electrocatalysts using ANFIS optimized by GA and PSO حسب Majedeh Gheytanzadeh (17541927)

Enhanced optical properties of <i>β</i>-Ga₂O₃-_<em>x</em>S_<em>x</em>S: A DFT study حسب G.B. Eshonqulov (22927297)

"…Here, we conduct systematic density functional theory calculations to study the effect of sulfur doping on the electronic and optical properties of <i>β</i>-Ga₂O₃. We find that the band gap of the material decreases with increasing sulfur content (from 4.81 eV to 1.59 eV), accompanied by symmetric shifts in both the valence-band offset and the conduction-band edge. …"

Design of an integrated system that combines the steam gasification of plastic waste and a solid oxide fuel cell for sustainable power generation حسب Khaled Abouemara (17823416)

"…Nernst voltage and SOFC output voltage also decreased (1.1 to 0.52 V and 1.1 to 0.78 V) as SOFC temperature increases. …"

Glycemic outcomes of Advanced Hybrid Closed Loop system in children and adolescents with Type 1 Diabetes, previously treated with Multiple Daily Injections (MiniMed 780G system in... حسب Goran Petrovski (129836)

"…HbA1c decreased from 8.6 ± 1.7% (70 ± 18.6 mmol/mol) at baseline, to 6.5 ± 0.7% (48 ± 7.7 mmol/mol) at the end of the study (<i>p</i> = 0.001). …"

PD-L1 Expression in Human Breast Cancer Stem Cells Is Epigenetically Regulated through Posttranslational Histone Modifications حسب Pramod Darvin (153341)

"…The active demethylation of PD-L1 promoter was confirmed by the increase in the distribution of 5hmC and decrease in 5mC levels and the upregulation of TET3 and downregulation of DNMTs enzymes in MCF-7 tumorspheres, compared with the cell line. …"

Dynamic Properties of Water Confined in Graphene-Based Membrane: A Classical Molecular Dynamics Simulation Study حسب One-Sun Lee (1291293)

"…We believe that our simulation results would be a significant contribution for designing a new graphene-based membrane for desalination.…"

Glycolytic overload-driven dysfunction of periodontal ligament fibroblasts in high glucose concentration, corrected by glyoxalase 1 inducer حسب Amal Ashour (6752957)

"…</p><h3>Results</h3><p dir="ltr">In high glucose concentration cultures, there was a ca. twofold increase in cellular MG, cellular protein MG-H1 content and decreased attachment of PDLFs to collagen-I. …"

Positive regulation of oxidative phosphorylation by nuclear myosin 1 protects cells from metabolic reprogramming and tumorigenesis in mice حسب Tomas Venit (17248420)

"…<p dir="ltr">Metabolic reprogramming is one of the hallmarks of tumorigenesis. Here, we show that nuclear myosin 1 (NM1) serves as a key regulator of cellular metabolism. …"

Epstein–Barr Virus Epidemiology, Serology, and Genetic Variability of LMP-1 Oncogene Among Healthy Population: An Update حسب Maria K. Smatti (4675852)

"…There are two main EBV genotypes, Type 1 and 2, distinguished by the differences in the EBNA-2 gene. …"

Unraveling the impaired incretin effect in obesity and type 2 diabetes: Key role of hyperglycemia-induced unscheduled glycolysis and glycolytic overload حسب Naila Rabbani (291722)

"…<p>Glucagon-like peptide-1 (GLP-1) agonists and GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) co-agonists are major treatment options for subjects with obesity and patients with type 2 diabetes mellitus (T2DM). …"

Loss of FOXA2 induces ER stress and hepatic steatosis and alters developmental gene expression in human iPSC-derived hepatocytes حسب Maryam Aghadi (17128819)

"…Here, we used FOXA2−/−iPSC lines to understand the role of FOXA2 on the development and function of human hepatocytes. …"

Insights Into SARS-CoV-2 S1-RBD-ACE2 Interaction Using Computational Tools and Membrane Microarray Platform حسب Angelin Mary Philip (21547421)

"…Further, treatment of cells with pitstop2, but not blebbistatin, resulted in a decrease in the S1-RBD depletion. Endocytosis likely plays a role in the initial interaction between S1-RBD and host cells, with the omicron variant showing enhanced interaction and depletion. …"