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Acting in the public interest
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Reply to Comments by Kakkar and Dahiya
Published 2014“…TO THE EDITOR: Chahine, Karaoui, and Mansour1 reviewed the efficacy and safety of bedaquiline in the treatment of adults with pulmonary multidrug-resistant tuberculosis (MDR-TB) and generally agree with the comments made by Kakkar and Dahiya.2 Bedaquiline was approved by the Food and Drug Administration based largely on results from phase 2 studies using sputum conversion as a surrogate marker for efficacy rather than long-term mortality data.2 Bedaquiline was shown to be associated with an unfavorable side effect profile, including an unexplained increased risk of mortality, QT prolongation, and elevated liver function tests.2 However, it is important to acknowledge that bedaquiline is the first novel drug to be approved for the treatment of TB in more than 4 decades and the communities devastated by MDR-TB are in desperate need for more options to manage their patients. …”
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NLRP7 inter-domain interactions
Published 2014Get full text
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Aneurysm ostium angle
Published 2011Get full text
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Fracture and stability of strain-softening materials and structures
Published 1990Get full text
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Climate change dynamics for global energy security and equity: Evidence from policy stringency drivers
Published 2024“…The findings reveal that increased financial integration significantly enhances ES by easing capital flow into energy infrastructure, which is crucial for stable energy supply chains. …”
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