Infliximab versus ciclosporin in steroid resistant acute severe ulcerative colitis: a model-based cost-utility analysis of data from CONSTRUCT pragmatic trial حسب Mohammed Fasihul Alam (6832217)

"…The study aimed to perform decision analytic model-based long-term cost-utility analysis (CUA) of infliximab versus ciclosporin for steroid-resistant ASUC investigated in CONSTRUCT pragmatic trial.</p><h3>Methods</h3><p dir="ltr">A decision tree (DT) model was developed using two-year health effect, resource use and costs data from CONSTRUCT trial to estimate relative cost-effectiveness of two competing drugs from the United Kingdom (UK) National Health Services (NHS) perspective. …"

Host Genetic Variants Potentially Associated With SARS-CoV-2: A Multi-Population Analysis حسب Maria K. Smatti (4675852)

"…Remarkably, Africans seem to carry extremely lower frequencies of SARS-CoV-1 susceptibility alleles, reaching to 32-fold decrease compared to other populations.</p><h3>Conclusion</h3><p dir="ltr">Multiple genetic variants, which could potentially modulate SARS-CoV-2 infection, are significantly variable between populations, with the lowest frequency observed among Africans. …"

The effect of daucus carota pentane-diethylether fraction on cancer cells motility and metastasis. (c2013) حسب Zgheib, Perla Z.

"…This was done through 2D, 3D and molecular assays. Upon treatment, a pronounced decrease in cancer cell motility was observed in the four cell lines used. …"
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The Effect of HuArgI (Co)-PEG5000 on The Migration of Ovarian Cancer حسب El Mais, Nour

"…In this study, we hypothesized that HuArgI (Co)- PEG5000 can decrease the migration of ovarian cancer cells. Our results show a decrease in the migratory rate of the cells and their rate in wound closure. …"
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Effects of ethanol addition to diesel–biodiesel blends on the CI engine characteristics حسب Fakher Hamdi (21225134)

"…All blends show an increase in brake mean effective pressure (BMEP) compared to B0, with the maximum enhancement observed in B10 with an average increase of 13% across all speeds. …"

Internet Searches for Medical Symptoms Before Seeking Information on 12-Step Addiction Treatment Programs: A Web-Search Log Analysis حسب George Nitzburg (18614989)

"…<h3>Background</h3><p dir="ltr">Brief intervention is a critical method for identifying patients with problematic substance use in primary care settings and for motivating them to consider treatment options. …"

Cardiorespiratory Fitness and Performance Adaptations to High-Intensity Interval Training: Are There Differences Between Men and Women? A Systematic Review with Meta-Analyses حسب Merilyn Lock (9440240)

"…Meta-analyses revealed similar increases in V̇ O_2max in women (g = 0.57; 95% CI 0.44–0.69) and men (g = 0.57; 95% CI 0.42–0.72), and powerAT in women (g = 0.38; 95% CI 0.13–0.64) and men (g = 0.38; 95% CI 0.11–0.64). Raw mean differences for change in V̇ O_2max were Δ 0.32 L·min⁻¹ and 3.50 mL·kg⁻¹·min⁻¹ in men, versus Δ 0.20 L·min⁻¹ and 3.34 mL·kg⁻¹·min⁻¹ for women. …"

Efficacy of Cannabidiol Combination with Cisplatin or Paclitaxel against Platinum-Resistant Ovarian Cancer Cell Lines حسب Ismail, Jana

"…Nonetheless, priming SK-OV-3 cells with CBD for 24h to sensitize them to the effect of cisplatin or paclitaxel treatment has shown to decrease the IC50 of the chemotherapeutic drugs. …"
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Comparative Effect of Sodium Butyrate and Sodium Propionate on Ovarian Cancer Migration, Invasion, and Epithelial-To-Mesenchymal Transition حسب Sleem, Reem

"…Unlike SKOV-3 cells, which demonstrated a decrease in E-cadherin and an increase in N-cadherin after treatment, the E-cadherin/N-cadherin profile in PA-1 treated cells exhibited an inverse pattern. …"
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Acute intense fatigue does not modify the effect of EVA and TPU custom foot orthoses on running mechanics, running economy and perceived comfort حسب Ken Van Alsenoy (14150559)

"…Flight time shortened (P = 0.026), peak braking (P = 0.016) and push-off (P = 0.032) forces decreased and vertical stiffness increased (P = 0.014) from before to after the repeated-sprint exercise, independent of footwear condition. …"

Wild carrot pentane-based fractions suppress proliferation of human HaCaT keratinocytes and protect against chemically-induced skin cancer حسب Shebaby, Wassim N.

"…The present study aims to examine the cytotoxic effect of Daucus carota oil fractions on human epidermal keratinocytes and evaluate the chemopreventive activity of the pentane diethyl ether fraction on DMBA/TPA induced skin carcinogenesis in mice. Methods Wild carrot oil extract was chromatographed to yield four fractions (F1, 100% pentane; F2, 50:50 pentane:diethyl ether; F3, 100% diethyl ether; F4 93:7 chloroform:methanol). …"
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Carotid artery revascularization through a radiated field حسب Lesèche, Guy

"…All patients were followed up for a mean of 40 months (range, 3-99 months). Results There was one (3.3%) perioperative death, from massive intracerebral hemorrhage; and 1 patient had a transient ischemic attack. …"
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Performance of Different Concrete Types Exposed to Elevated Temperatures: A Review حسب Alhamad, Amjad

"…Most of the concrete types show a moderate and steady decrease in the strength up until 400 °C. However, the decrease is more rapid until the concrete reaches 800 °C or 1000 °C at which it spalls or cannot take any applied load. …"
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Location matters: spatial dynamics of tumor-infiltrating T cell subsets is prognostic in colon cancer حسب Hehuan Zhu (4808445)

"…We demonstrated an increase in immune cell density and a decrease in the distance of CD3⁺CD8⁺ T cells to the nearest tumor cell, in the immune active, ICR High, immune subtypes. …"

Clotted blood samples in the neonatal intensive care unit: A retrospective, observational study to evaluate interventions to reduce blood sample clotting حسب Matheus F. P. T. van Rens (17993767)

"…When blood samples clot before analysis, they are rejected, which delays treatment decisions and necessitates repeated sampling.</p><h3>Aims</h3><p dir="ltr">To decrease the incidence of rejected blood samples taken for laboratory investigation as a result of clotted sample.…"

Predictors of mortality and morbidity in critically ill COVID‐19 patients: An experience from a low mortality country حسب Mohamad Y. Khatib (11659459)

"…We sought to determine these in a large cohort of critically ill COVID-19 patients in Qatar and explore the early mortality predictors. </p><h3>Methods</h3><p dir="ltr">We retrospectively studied the clinical characteristics and outcomes in patients admitted to the ICU at the national referral hospital for COVID-19 patients in Qatar. …"

Soluble ACE2 and angiotensin II levels are modulated in hypertensive COVID-19 patients treated with different antihypertension drugs حسب Mohamed A. Elrayess (21398687)

"…The length of hospital stay is correlated with ACE2 levels (<i>r </i>= 0.3, <i>p </i>= 0.003). Angiotensin II levels decreased with severity (<i>p</i> = 0.04). …"

Deletion of <i>RFX6</i> impairs iPSC-derived islet organoid development and survival, with no impact on PDX1⁺/NKX6.1⁺ progenitors حسب Noura Aldous (15429873)

"…Here, we aimed to understand the mechanisms underlying the impairment of pancreatic islet development and subsequent hypoplasia due to loss-of-function mutations in <i>RFX6</i>.</p><h3>Methods</h3><p dir="ltr">We examined regulatory factor X6 (RFX6) expression during human embryonic stem cell (hESC) differentiation into pancreatic islets and re-analysed a single-cell RNA-seq dataset to identify RFX6-specific cell populations during islet development. …"

Prehospital plasma transfusion versus standard of care following traumatic injury: a review of the systematic reviews and a meta-analysis حسب Ayman El-Menyar (440103)

"…By compiling all existing evidence, we aimed to investigate whether prehospital plasma (PHP) transfusion can be safely administered and improve the clinical outcomes of trauma patients.</p><h3 dir="ltr">Methods</h3><p dir="ltr">A systematic review (SR) and meta-analysis were conducted in accordance with the PRISMA guidelines to assess the effectiveness and safety of PHP transfusion compared to the standard of care in trauma patients. …"

Two-surgeon technique of parenchymal transection contributes to reduced transfusion rate in patients undergoing major hepatectomy حسب Palavecino, Martin

"…Conclusion Although most factors that affect the red cell transfusion rate for liver resection are patient- or tumor-related, the parenchymal transection technique is under the surgeon's control. The decrease in transfusion rate associated with the use of the 2-surgeon technique emphasizes the important role of the hepatobiliary surgeon in determining outcomes after liver resection. …"
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