Connexin 43 Loss Triggers Cell Cycle Entry and Invasion in Non-Neoplastic Breast Epithelium: A Role for Noncanonical Wnt Signaling حسب Fostok, Sabreen

"…This study aims to investigate the role of Cx43 in proliferation and invasion starting from non-neoplastic breast epithelium. (2) Methods: Nontumorigenic human mammary epithelial HMT-3522 S1 cells and Cx43 shRNA-transfected counterparts were cultured under 2-dimensional (2-D) and 3-D conditions. (3) Results: Silencing Cx43 induced mislocalization of β-catenin and Scrib from apicolateral membrane domains in glandular structures or acini formed in 3-D culture, suggesting the loss of apical polarity. …"
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Optimal management, prevalence, and clinical behavior of saddle pulmonary embolism: A systematic review and meta-analysis حسب Fateen Ata (12217764)

"…We aimed to pool the available data on the clinical behavior and outcomes of SPE and study the effects of various treatment modalities on mortality outcomes.</p><h3>Methods</h3><p dir="ltr">PubMed, Scopus, and Google Scholar were searched for articles (any date up to February 28, 2022) reporting patients with SPE. …"

Hardware Trojan Mitigation Technique in Network-on-Chip (NoC) حسب Musharraf Hussain (17541498)

"…Compared to the runtime HT mitigation method, the proposed scheme also decreases the average latency for the hardware Trojan inserted in the flit’s header, tail, and destination field up to 14.7%, 8%, and 3%, respectively.…"

Finding novel targets for the treatment and reversal of type 2 diabetes mellitus and obesity حسب Imran Ramzan (15430807)

"…Individually, both valine (245 ± 33 to 105 ± 23 µmol/L; p < 0.0001), and leucine (130 ± 20 to 75 ± 13 µmol/L; p < 0.05), decreased significantly in response to the BCAA-restricted diet. …"

Role of two efflux proteins, ABCB1 and ABCG2 in blood-brain barrier transport of bromocriptine in a murine model of MPTP-induced dopaminergic degeneration حسب Milane, Aline

"…Conversely, ABCG2 expression studied on brain capillaries from MPTP-treated mice was decreased (1.3-fold, p<0.05) and ABCB1 expression increased (1.43-fold, p<0.05) as an off-setting of brain transport. …"
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Self-Reported Sleep and Exercise Patterns in Patients with Schizophrenia: a Cross-Sectional Comparative Study حسب Nancy Kiwan (12451992)

"…The purpose of this study is to study the sleep and exercise patterns in Arab patients with schizophrenia compared with those of healthy controls.</p><h3>Method</h3><p dir="ltr">A total of 99 patients with schizophrenia and 101 controls were recruited. …"

AI-driven wearable sensors for postoperative monitoring in surgical patients: A systematic review حسب Muhammad Mohsin Khan (22150360)

"…This systematic review discusses how the integration of artificial intelligence with wearable technology can help address some of the limitations in postoperative monitoring. </p><h3>Methods</h3><p dir="ltr">We did a Systematic review on literature published between 2000 and 2024 English articles or those with text English translations. …"

Trends and levels of the global, regional, and national burden of appendicitis between 1990 and 2021: findings from the Global Burden of Disease Study 2021 حسب Letourneau, Ian D

"…Although mortality rates due to appendicitis decreased in all regions, there were large regional variations in the temporal trend in incidence. …"
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Coats disease in Saudi Arabia حسب Alqahtani, Abdullah A.

"…The reason for presentation was decreased vision in 11 cases (55 %), strabismus in 4 (20 %), leukocoria in 2 (10 %), and others in 3 (15 %) . …"
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A component analysis of positive behaviour support plans حسب Grey, Ian

"…This paper investigates which components are most effective and which factors might mediate effectiveness. Method Sixty-one staff working with individuals with intellectual disability and challenging behaviours completed longitudinal competency-based training in PBS. …"
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Long non-coding RNA MALAT1 promotes steatosis in HepG2 cells by modulating target gene expression in presence of Exendin-4 حسب Olfa Khalifa (10914452)

"…</p> <p>Results: Treatment with 200nM Ex-4 for 3h decreased the OA-induced lipid buildup significantly (p<0.05). …"

A Modification to Enhance the Survival of the Island FDMA Flap by Adding a Skin Bridge حسب Salim Al Lahham (16515333)

"…We combined Foucher and Holevich characteristics to design a flap that promises to solve the problem.</p><h3>Methods</h3><p dir="ltr">This is a case series that includes 9 patients where we describe a technique that has the potential to enhance the survival of the first dorsal metacarpal artery (FDMA) flap and decreases the rate of distal necrosis via addition of a 5-mm skin bridge to the pedicle and by avoiding tunneling. …"

Investigation of the Effect of Imatinib and Hydroxyurea Combination Therapy on Hematological Parameters and Gene Expression in Chronic Myeloid Leukemia (CML) Patients حسب Esraa K. Al-Amleh (16023071)

"…Platelet counts, on the other hand, dramatically decreased in both IM and (HU + IM).</p><h3>Conclusion</h3><p dir="ltr">Because the studied genes (BCL2, PP2A, CIP2A, and WT1) are participating in cell proliferation and death, the findings show that the examined genes are significant to understand the efficacy of various therapies. …"

Intravitreal bevacizumab (Avastin) treatment of retinal angiomatous proliferation حسب Ghazi, Nicola G.

"…Six eyes underwent fluorescein angiography at the 12-week follow-up visit; 3 (50%) of these eyes had decreased leakage compared with baseline. …"
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Enhancing the corrosion resistance of reinforcing steel under aggressive operational conditions using behentrimonium chloride حسب A. Bahgat Radwan (9631720)

"…Herein, the inhibition efficiency of a new corrosion inhibitor, behentrimonium chloride (BTC, C25H54ClN), is explored in a simulated-concrete pore solution (SCP) with 3.5 wt.% NaCl at different pH using electrochemical impedance spectroscopy (EIS) and polarization methods. …"

Rising mortality related to cardiovascular disease and prostate cancer amongst older men across the United States حسب Abdul Ahad (545575)

"…States with AAMRs ranking in the 90th percentile were Nebraska, California, North Dakota, the District of Columbia, and Mississippi. </p><h3>Conclusion</h3><p dir="ltr">After decreasing death rates associated with CVD and PCa from 1999 to 2015, a reversal in the trend was observed from 2015 to 2019. …"

Impact of the fear of Covid-19 infection on intent to breastfeed; a cross sectional survey of a perinatal population in Qatar حسب Shuja Mohd Reagu (12051406)

"…</p><h3>Conclusions</h3><p dir="ltr">The rates of Obsessive–compulsive symptoms were increased and the rates of intent to breastfeed were decreased when compared with pre pandemic rates. …"

Comparison of Burr-Hole Craniostomy versus Twist-Drill Craniostomy Operations for Patients with Chronic Subdural Hematoma: A Systematic Review and Network Meta-Analysis حسب Mohammed Maan Al-Salihi (13105835)

"…This study aims to compare the safety and efficacy of single burr-hole craniostomy (sBHC), double burr-hole craniostomy (dBHC), and twist-drill craniostomy (TDC) in patients with CSDH.</p><p><br></p><h3>Methods</h3><p dir="ltr">We searched PubMed, Embase, Scopus, Cochrane, and Web of Science until October 2022 for prospective trials. …"

The immune landscape of solid pediatric tumors حسب Shimaa Sherif (12862990)

"…Upregulation of the WNT/Beta-catenin pathway was associated with unfavorable outcomes and decreased T-cell infiltration in OS.</p><h3>Conclusions</h3><p dir="ltr">We demonstrated that extracranial pediatric tumors could be classified according to their immune disposition, unveiling similarities with adults’ tumors. …"

Assessing the risk of angiotensin receptor blockers on major cardiovascular events: a systematic review and meta-analysis of randomized controlled trials حسب Yara Wanas (8744844)

"…The aim of the meta-analysis was to synthetize the available evidence of randomised controlled trials (RCTs) and elucidate if ARBs increase the risk of cardiovascular events.</p><h3>Methods</h3><p dir="ltr">A comprehensive search was conducted to identify RCTs that assessed the safety of ARBs. …"