Small molecule inhibitors of α-synuclein oligomers identified by targeting early dopamine-mediated motor impairment in C. elegans حسب Kevin S. Chen (9201767)

"…Together with artificial intelligence-driven in silico and in vitro screening, this C. elegans model identified five compounds that reduced motor dysfunction induced by α-synuclein. Three of these compounds also decreased α-synuclein oligomers in mammalian neurons, including rifabutin which has not been previously investigated for Parkinson’s disease. …"

SARS‐CoV‐2 infection triggers more potent antibody‐dependent cellular cytotoxicity (ADCC) responses than mRNA‐, vector‐, and inactivated virus‐based COVID‐19 vaccines حسب Hadeel T. Zedan (12535521)

"…Here, we investigated ADCC activity in convalescent sera from infected patients with wild‐type (WT) severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) or omicron variant compared with three coronavirus disease 2019 (COVID‐19) vaccine platforms and postvaccination breakthrough infection (BTI). …"

Research on the potential of photovoltaic technologies in reducing energy consumption in an urban mixed use residential community. A Case study for net zero energy community in Dub... حسب SUGATHAN, SANAL

"…This paper illustrates the many strategies to bridge the deficiency energy gap in three categories; 1) increase PV panel energy production by optimizing the orientation, inclination angle, manual tracking, enhanced microcontrollers and inverters, 2) increase PV panel efficiency from better manufacturers, 3) increase the area of PV panel installation on the building fabric and exploring options beyond the building footprint at the community level. …"
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Biochar from food waste: a sustainable amendment to reduce water stress and improve the growth of chickpea plants حسب Snigdhendubala Pradhan (9872262)

"…Two biochar application rates improved soil quality by increasing soil porosity from 49.3 to ≥ 53.4%, more than doubling cation exchange capacity to ≥ 21.1 cmolc.kg−1, providing a small reduction in bulk density of approximately 10% and decreasing electrical conductivity of the extract by at least 40% in comparison to control condition. …"

Global, regional, and national burden of respiratory tract cancers and associated risk factors from 1990 to 2019: a systematic analysis for the Global Burden of Disease Study 2019 حسب Hedyeh Ebrahimi (7321358)

"…Global age-standardised incidence rates of tracheal, bronchus, and lung cancer decreased by 7·4% (−16·8 to 1·6) and age-standardised incidence rates of larynx cancer decreased by 3·0% (−10·5 to 5·0) in males over the past decade; however, during the same period, age-standardised incidence rates in females increased by 0·9% (−8·2 to 10·2) for tracheal, bronchus, and lung cancer and decreased by 0·5% (−8·4 to 8·1) for larynx cancer. …"

Enhanced oil recovery using hyperbranched polyglycerol polymer-coated silica nanoparticles حسب Wamda Faisal Elmobarak (17058024)

"…A D_PSiMNPs = 100 mg/L was sufficient to achieve %η_dem of 99.4% for C_oil = 100 mg/L and slightly decreased to ~93% for C_oil ~4000 mg/L. The PSiMNPs can be reused up to 15 times with a steady %η_dem of 89.1% for C_oil = 100 mg/L and 88.6% for C_oil = 4000 mg/L. …"

Measuring routine childhood vaccination coverage in 204 countries and territories, 1980–2019: a systematic analysis for the Global Burden of Disease Study 2020, Release 1 حسب Natalie C Galles (9715361)

"…However, over the past decade, global vaccine coverage broadly plateaued; 94 countries and territories recorded decreasing DTP3 coverage since 2010. Only 11 countries and territories were estimated to have reached the national GVAP target of at least 90% coverage for all assessed vaccines in 2019.…"

Carbonate effects on hexavalent uranium removal from water by nanocrystalline titanium dioxide حسب Wazne, Mahmoud

"…However, the capacity of the nanocrystalline titanium dioxide to remove U(VI) from water decreased in the presence of inorganic carbonate at pH > 6.0. …"
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Global, regional, and national burden of hepatitis B, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019 حسب Brittney S Sheena (9715568)

"…The number of HBV-related deaths increased between 1990 and 2019 (by 5·9% [–5·6 to 19·2]) and between 2015 and 2019 (by 2·9% [–5·9 to 11·3]). By contrast, all-age and age-standardised death rates due to HBV-related diseases decreased during these periods. …"

The global, regional, and national burden of colorectal cancer and its attributable risk factors in 195 countries and territories, 1990–2017: a systematic analysis for the Global B... حسب Saeid Safiri (3713035)

"…There was a non-linear association between the Socio-demographic Index and the Healthcare Access and Quality Index and age-standardised DALY rates. In 2017, the three largest contributors to DALYs at the global level, for both sexes, were diet low in calcium (20·5% [12·9–28·9]), alcohol use (15·2% [12·1–18·3]), and diet low in milk (14·3% [5·1–24·8]).…"

Global, regional, and national burden of stroke and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019 حسب Valery L Feigin (5320574)

"…In 2019, the age-standardised stroke-related mortality rate was 3·6 (3·5–3·8) times higher in the World Bank low-income group than in the World Bank high-income group, and the age-standardised stroke-related DALY rate was 3·7 (3·5–3·9) times higher in the low-income group than the high-income group. …"

Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults حسب Nowell H, Phelps

"…From 1990 to 2022, the combined prevalence of thinness and obesity decreased among girls in five countries (3%) and among boys in 15 countries (8%) with a posterior probability of at least 0·80, and increased among girls in 140 countries (70%) and boys in 137 countries (69%) with a posterior probability of at least 0·80. …"
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Global, regional, and national mortality among young people aged 10–24 years, 1950–2019: a systematic analysis for the Global Burden of Disease Study 2019 حسب Joseph L Ward (9715619)

"…Since 1950, deaths in this age group decreased by 30·0% in females and 15·3% in males, and sex-based differences in mortality rate have widened in most regions of the world. …"

Temporal patterns of cancer burden in Asia, 1990–2019: a systematic examination for the Global Burden of Disease 2019 study حسب Rajesh, Sharma

"…This study examines the temporal patterns of incidence, mortality, disability and risk factors of 29 cancers in Asia in the last three decades. MethodsThe age, sex and year-wise estimates of incidence, mortality, and disability-adjusted life years (DALYs) of 29 cancers for 49 Asian countries from 1990 through 2019 were generated as a part of the Global Burden of Disease, Injuries and Risk Factors 2019 study. …"
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Analysis of Innovative Vapor Compression and Thermal Energy Storage Systems Using Alternative Refrigerants حسب Morad, Bahaa

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The global, regional, and national burden of oesophageal cancer and its attributable risk factors in 195 countries and territories, 1990–2017: a systematic analysis for the Global... حسب Farin Kamangar (63964)

"…In 2017, age-standardised incidence was 2·7 times higher, mortality 2·9 times higher, and DALYs 3·0 times higher in males than in females. …"

Investigation of the Effect of Imatinib and Hydroxyurea Combination Therapy on Hematological Parameters and Gene Expression in Chronic Myeloid Leukemia (CML) Patients حسب Esraa K. Al-Amleh (16023071)

"…When compared to single medicines, the combination treatment reduced the proportion of neutrophils to normal reference ranges. Platelet counts, on the other hand, dramatically decreased in both IM and (HU + IM).…"

Caloric restriction reduces trabecular bone loss during aging and improves bone marrow adipocyte endocrine function in male mice حسب Charlotte Rinne (18766966)

"…No negative effects of CR on bone regeneration were evident in either young or aged mice.</p><h3>Discussion</h3><p dir="ltr">Our findings indicate that the timing of CR is critical and may exert detrimental effects on bone biology if administered during a phase of active skeletal growth. …"

PSA-activated proaerolysin as a prostate specific cancer therapy حسب Abi-Habib, Ralph

"…Indeed the ratio of PRX302 to proaerolysin cleavage by PSA was more than 40 times that of any other protease tested. As expected, native proaerolysin was effectively cytotoxic at low pM concentrations in all cells tested (LNCaP, DU145, CWR22Rvi, PC3, PrEC, and RWPE2-W99). …"
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From metabolic dysregulation to neurodegenerative pathology: the role of hyperglycemia, oxidative stress, and blood-brain barrier breakdown in T2D-driven Alzheimer’s disease حسب Ahmad Raza (18205961)

"…Moreover, the overactivity of glycogen synthase kinase-3 beta (GSK-3β) also triggers taurine protein pathology. …"