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701
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702
Small molecule inhibitors of α-synuclein oligomers identified by targeting early dopamine-mediated motor impairment in C. elegans
Published 2021“…Together with artificial intelligence-driven in silico and in vitro screening, this C. elegans model identified five compounds that reduced motor dysfunction induced by α-synuclein. Three of these compounds also decreased α-synuclein oligomers in mammalian neurons, including rifabutin which has not been previously investigated for Parkinson’s disease. …”
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703
SARS‐CoV‐2 infection triggers more potent antibody‐dependent cellular cytotoxicity (ADCC) responses than mRNA‐, vector‐, and inactivated virus‐based COVID‐19 vaccines
Published 2024“…Here, we investigated ADCC activity in convalescent sera from infected patients with wild‐type (WT) severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) or omicron variant compared with three coronavirus disease 2019 (COVID‐19) vaccine platforms and postvaccination breakthrough infection (BTI). …”
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704
Towards the development of an integrated model for examining the determinants affecting the use of Queue Management Solutions in Healthcare
Published 2021“…Therefore, this research has three main objectives. First, conducting a systematic review to address the research gaps in the existing literature and understand the extensively utilized acceptance models in healthcare and their related constructs. …”
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705
The Effect of Experimental Recuperative and Appetitive Post-lunch Nap Opportunities, With or Without Caffeine, on Mood and Reaction Time in Highly Trained Athletes
Published 2021“…</p><h3>Methods</h3><p dir="ltr">Twenty-three highly trained athletes (<i>study 1</i>; 9 and <i>study 2</i>; 14) performed four test sessions (PLA, CAF, N20 and CAF+N20) in double-blind, counterbalanced and randomized order. …”
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706
Urban Geometry: The Effect of Height Diversity and Buildings Configuration on Thermal Performance and Cooling Load at Urban Scale. A Case Study in Dubai / UAE
Published 2018“…., the Dubai / UAE local context and weather characteristics. Three groups with 56 proposed scenarios were simulated, where in different ratios of building height variation were implemented in the first two groups, and different building configurations were adopted for the third group. …”
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707
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708
High-sensitive detection and quantitation of thyroid-stimulating hormone (TSH) from capillary/fingerstick and venepuncture whole-blood using fluorescence-based rapid lateral flow i...
Published 2023“…<h3>Background </h3><p dir="ltr">In the last decade, point of care testing (POCT) such as lateral flow immunoassays (LFIA) were developed for rapid TSH measurement. …”
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709
Research on the potential of photovoltaic technologies in reducing energy consumption in an urban mixed use residential community. A Case study for net zero energy community in Dub...
Published 2018“…This paper illustrates the many strategies to bridge the deficiency energy gap in three categories; 1) increase PV panel energy production by optimizing the orientation, inclination angle, manual tracking, enhanced microcontrollers and inverters, 2) increase PV panel efficiency from better manufacturers, 3) increase the area of PV panel installation on the building fabric and exploring options beyond the building footprint at the community level. …”
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710
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711
Prevalence and attributable health burden of chronic respiratory diseases, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017
Published 2020“…However, when accounting for ageing and population growth, declines were observed in age-standardised prevalence (14·3% decrease), age-standardised death rates (42·6%), and age-standardised DALY rates (38·2%). …”
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712
Global fertility in 204 countries and territories, 1950–2021, with forecasts to 2100: a comprehensive demographic analysis for the Global Burden of Disease Study 2021
Published 2024“…The share of livebirths was projected to decline between 2021 and 2100 in most of the six other super-regions—decreasing, for example, in south Asia from 24·8% (23·7–25·8) in 2021 to 16·7% (14·3–19·1) in 2050 and 7·1% (4·4–10·1) in 2100—but was forecast to increase modestly in the north Africa and Middle East and high-income super-regions. …”
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713
Global, regional, and national burden of respiratory tract cancers and associated risk factors from 1990 to 2019: a systematic analysis for the Global Burden of Disease Study 2019
Published 2021“…Global age-standardised incidence rates of tracheal, bronchus, and lung cancer decreased by 7·4% (−16·8 to 1·6) and age-standardised incidence rates of larynx cancer decreased by 3·0% (−10·5 to 5·0) in males over the past decade; however, during the same period, age-standardised incidence rates in females increased by 0·9% (−8·2 to 10·2) for tracheal, bronchus, and lung cancer and decreased by 0·5% (−8·4 to 8·1) for larynx cancer. …”
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714
The global, regional, and national burden of colorectal cancer and its attributable risk factors in 195 countries and territories, 1990–2017: a systematic analysis for the Global B...
Published 2019“…There was a non-linear association between the Socio-demographic Index and the Healthcare Access and Quality Index and age-standardised DALY rates. In 2017, the three largest contributors to DALYs at the global level, for both sexes, were diet low in calcium (20·5% [12·9–28·9]), alcohol use (15·2% [12·1–18·3]), and diet low in milk (14·3% [5·1–24·8]).…”
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715
Global, regional, and national burden of HIV/AIDS, 1990–2021, and forecasts to 2050, for 204 countries and territories: the Global Burden of Disease Study 2021
Published 2024“…BackgroundAs set out in Sustainable Development Goal 3.3, the target date for ending the HIV epidemic as a public health threat is 2030. …”
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716
Global, regional, and national mortality among young people aged 10–24 years, 1950–2019: a systematic analysis for the Global Burden of Disease Study 2019
Published 2021“…Since 1950, deaths in this age group decreased by 30·0% in females and 15·3% in males, and sex-based differences in mortality rate have widened in most regions of the world. …”
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717
Temporal patterns of cancer burden in Asia, 1990–2019: a systematic examination for the Global Burden of Disease 2019 study
Published 2024“…This study examines the temporal patterns of incidence, mortality, disability and risk factors of 29 cancers in Asia in the last three decades. MethodsThe age, sex and year-wise estimates of incidence, mortality, and disability-adjusted life years (DALYs) of 29 cancers for 49 Asian countries from 1990 through 2019 were generated as a part of the Global Burden of Disease, Injuries and Risk Factors 2019 study. …”
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718
The ras/cAMP-dependent protein kinase signaling pathway regulates an early step of the autophagy process in saccharomyces cerevisiae
Published 2004“…When faced with nutrient deprivation, Saccharomyces cerevisiae cells enter into a nondividing resting state, known as stationary phase. The Ras/PKA (cAMP-dependent protein kinase) signaling pathway plays an important role in regulating the entry into this resting state and the subsequent survival of stationary phase cells. …”
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719
The ras/cAMP-dependent protein kinase signaling pathway regulates an early step of the autophagy process in saccharomyces
Published 2004“…When faced with nutrient deprivation, Saccharomyces cerevisiae cells enter into a nondividing resting state, known as stationary phase. The Ras/PKA (cAMP-dependent protein kinase) signaling pathway plays an important role in regulating the entry into this resting state and the subsequent survival of stationary phase cells. …”
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720
Biochar from food waste: a sustainable amendment to reduce water stress and improve the growth of chickpea plants
Published 2022“…Two biochar application rates improved soil quality by increasing soil porosity from 49.3 to ≥ 53.4%, more than doubling cation exchange capacity to ≥ 21.1 cmolc.kg−1, providing a small reduction in bulk density of approximately 10% and decreasing electrical conductivity of the extract by at least 40% in comparison to control condition. …”