Inhibiting HSP90 changes the expression pattern of PINK1 and BNIP3 and induces oxidative stress in colon cancer cells by Ejlal Abu-El-Rub (5168183)

“…Similarly, genetic knockdown of HSP90 in RKO cells produced comparable effects, including reduced cell survival and a decreased PINK1/BNIP3 ratio.</p><h3>Conclusion</h3><p dir="ltr">Targeting HSP90 in colon cancer cells disrupts their survival by decreasing PINK1 and increasing BNIP3, which activates oxidative and endoplasmic reticulum stress, ultimately triggering apoptosis.…”

Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications by Sumama Nuthana Kalva (17302906)

“…Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …”

PGAP3 Associated with Hyperphosphatasia with Mental Retardation Plays a Novel Role in Brain Morphogenesis and Neuronal Wiring at Early Development by Sahar I. Da’as (9631717)

“…<p dir="ltr">Recessive mutations in Post-GPI attachment to proteins 3 (PGAP3) cause the rare neurological disorder hyperphosphatasia with mental retardation syndrome 4 type (HPMRS4). …”

The Effect of High Dose Isoflavone Supplementation on Serum Reverse T3 in Euthyroid Men With Type 2 Diabetes and Post-menopausal Women by Thozhukat Sathyapalan (704787)

“…Thyroid stimulating hormone (TSH) serum concentrations increased while free thyroxine (fT₄) concentrations decreased with 3 months of SPI compared to SP supplementation for both men and women. rT₃ correlated with TSH in both studies (<i>p</i> = 0.03) but not with either fT₃ or fT₄. fT₃ levels did not differ between the SPI and SP preparations.…”

Transcriptome Profile Identifies Actin as an Essential Regulator of Cardiac Myosin Binding Protein C3 Hypertrophic Cardiomyopathy in a Zebrafish Model by Sahar Isa Da’as (18288880)

“…To investigate the c-MYBPC3 HCM-related cardiac impairment, we generated a zebrafish mypbc3-knockout model. …”

A 28 nm CMOS 10 bit 100 MS/s Asynchronous SAR ADC with Low-Power Switching Procedure and Timing-Protection Scheme by Fang Tang (116243)

“…A single-side-fixed technique is utilized to reduce the number of capacitors; a parallel split capacitor array in combination with a partially thermometer coded technique can minimize the switching energy, improve speed, and decrease differential non-linearity (DNL). In addition, a compact timing-protection scheme is proposed to ensure the stability of the asynchronous SAR ADC. …”

The ortholog of human ssDNA-binding protein SSBP3 influences neurodevelopment and autism-like behaviors in <i>Drosophila melanogaster</i> by Safa Salim (9186786)

“…One such gene is the single-stranded DNA-binding protein 3 (<i>SSBP3</i>) and its Drosophila melanogaster ortholog is called sequence-specific single-stranded DNA-binding protein (<i>Ssdp</i>). …”

Thermoelectric power of (Cu0.5Tl0.5)-1223 superconducting phase added with BaSnO3 nanoparticles by Srour, A.

“…In this study, we report the thermoelectric power (TEP) measurements of Cu0.5Tl0.5Ba2Ca2Cu3O10-δ added with BaSnO3 nanoparticles. BaSnO3 nanoparticles were prepared by chemical co-precipitation method, while (BaSnO3)x/(CuT1)-1223 superconducting samples with 0.00 ≤ x ≤ 1.50 wt% were prepared using the solid-state reaction method. …”
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Visible Light Photocatalytic Activity of Ag/WO₃ Nanoparticles and its Antibacterial Activity Under Ambient Light and in The Dark by Maha Matalkeh (17148358)

“…Ultraviolet–visible spectra analysis observed a large redshift in the absorbing band edge and decreased bandgap energy from 2.6 to 2.1 eV. Photocatalytic analysis at different concentrations of 1% Ag/WO₃ under visible light indicated a high degradation efficiency. …”

Antitumor activity of β-2-himachalen-6-ol in colon cancer is mediated through its inhibition of the PI3K and MAPK pathways by Daaboul, Hamid E.

“…Western blot analysis revealed a significant decrease in p-Erk, p-Akt, pro-caspase-3 and Bcl-2 and an increase in p53, p21, Bax and PARP proteins. …”
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The Effect of Soy Isoflavones on Steroid Metabolism by Amanda C. Swart (18153814)

“…Effects of genistein and daidzein on steroid metabolism were determined in vitro, in HEK293 cells expressing CYP17A1 and in the human adrenocortical carcinoma H295R cell model.</p><h3>Results</h3><p dir="ltr">SPI decreased serum dehydroepiandrosterone sulfate (DHEAS) levels in both men and women (P < 0.01), with decreased androstenedione (A4) (P < 0.01) in women not observed in men (P < 0.86). …”

Microstructure and Compressive Behavior of Al–Y₂O₃ Nanocomposites Prepared by Microwave-Assisted Mechanical Alloying by Manohar Reddy Mattli (18147568)

“…The mechanical properties of the Al–Y₂O₃ nanocomposites increased as the addition of yttria reached to 1.5 vol. % and thereafter decreased. …”

Did the periodic intensification of routine immunisation strategy (Intensified mission Indradhanush) reduce the demand for pediatric antibiotic formulations in India? by Habib Hasan Farooqui (7861166)

“…We used Newey–West standard errors to account for autocorrelation and heteroskedasticity.</p><h3>Findings</h3><p dir="ltr">Poisson segmented regression analysis showed a 12.6% decrease in Fluoroquinolones sales in the first month of IMI implementation (incidence rate ratio [IRR] 0.874, 95%CI: 0.777–0.983). …”

Novel Wire Gripper for Robotics Picking of Small Green Parts From Powder Bed of Binder Jet Metal Additive Manufacturing by Abdulhamid Mathkur (22467373)

“…The adaptable gripper system fits different part geometries to decrease the chance of component deformation or fracturing. …”

Global time differences in road traffic injuries among children and adolescents between and 1990 and 2013: Regional and economical perspectives from global burden of diseases study by Uzma Rahim Khan (19794408)

“…To highlight changes over time in RTI mortality among children and adolescents VRU and non-VRU globally, by region, and by country income level between 1990 and 2013. …”

Novel proteins implicated in lipid metabolism disorders by Nature Research (16552612)

“…</p><p>ANGPTL3 is a protein secreted by the liver, belonging to the angiopoietin-like family of eight proteins. …”

Transport, magnetic and structural properties of(Tl0.5Pb0.5)Sr2-xCexCa2Cu3Oy compounds by Hamdan, N.M.

“…Resistivity, DC magnetization and X-ray diffraction measurements were performed on 6 sample with nominal composition (Tl0.5Pb 0.5)Sr2-xCexCa2Cu3 Oy, with x=0.0, 0.1, 0.2, 0.3, 0.4 and 0.5. As cerium content was increased, the transition temperature increased up to about 6 K when x=0.1. …”
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Double versus triple arthrodesis for adult-acquired flatfoot deformity due to stage III posterior tibial tendon insufficiency: a prospective comparative study of two cohorts by Amr A. Fadle (14150298)

“…All patients in both groups achieved union by four months post-operatively. The mean time to union in the double and triple arthrodesis groups was 3.39 ± 0.65 vs. 3.31 ± 0.6 months, respectively, with no statistically significant differences (p = 0.77). …”

STEM: spatial speech separation using twin-delayed DDPG reinforcement learning and expectation maximization by Muhammad Salman Khan (7202543)

“…Additionally, it reduces the required training data by 39 times, training time by 36 times, model size by 6 times, real time factor (RTF) by 1 point, and multiply-accumulate operations (MACs) by 9 times compared to a recently proposed lightweight transformer-based encoder-decoder framework, while offering a slight decrease in PESQ score (by 0.45 points).…”

Daucus carota Pentane-Based Fractions Suppress Proliferation and Induce Apoptosis in Human Colon Adenocarcinoma HT-29 Cells by Inhibiting the MAPK and PI3K Pathways by Shehaby, Wassim N.

“…Western blot revealed the activation of caspase-3, PARP cleavage, and a considerable increase in Bax and p53 levels, and a decrease in Bcl-2 level. …”
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