A novel inhibitor of signal transducers and activators of transcription 3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T ce... حسب Abou-Ghazal, Mohamed

"…Results: WP1066 achieved an IC50 of 1.6, 2.3, and 1.5 μmol/L against melanoma cell line A375, B16, and B16EGFRvIII, respectively. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Novel proteins implicated in lipid metabolism disorders حسب Nature Research (16552612)

"…</p><p>ANGPTL3 is a protein secreted by the liver, belonging to the angiopoietin-like family of eight proteins. …"

Transport, magnetic and structural properties of(Tl0.5Pb0.5)Sr2-xCexCa2Cu3Oy compounds حسب Hamdan, N.M.

"…Resistivity, DC magnetization and X-ray diffraction measurements were performed on 6 sample with nominal composition (Tl0.5Pb 0.5)Sr2-xCexCa2Cu3 Oy, with x=0.0, 0.1, 0.2, 0.3, 0.4 and 0.5. As cerium content was increased, the transition temperature increased up to about 6 K when x=0.1. …"
احصل على النص الكامل
احصل على النص الكامل

ZnO-Doped gC₃N₄Nanocapsules for Enhancing the Performance of Electroless NiP Coating─Mechanical, Corrosion Protection, and Antibacterial Properties<sub>3</sub... حسب Fatma Nabhan (16324958)

"…The highest corrosion resistance is achieved on the heat-treated NiP-C₃N₄/1.0 wt % ZnO coatings. Although the presence of ZnO in the C₃N₄ nanocapsules increased its surface area and porosity, the C₃N₄/ZnO nanocapsules prevented localized corrosion by filling the microdefects and pores of the NiP matrix. …"

Development of flexible PVDF/ BaTiO₃-MoS₂ polymer nanocomposites for energy harvesting and gas sensing applications حسب Hemalatha Parangusan (6556133)

"…The electroactive, β-phase of the PVDF is shown to increase with the addition of BaTiO₃–MoS₂ fillers as a result of the filler’s good interfacial interaction with the polymer matrix. …"

Recognizing Plastic Threats in Baggage X-Rays Using Deep Networks حسب Alawar, Mohammad Suhail Abdulwahid Abdulrahman

احصل على النص الكامل

Omega-3 fatty acid-rich fish oil supplementation prevents rosiglitazone-induced osteopenia in aging C57BL/6 mice and in vitro studies حسب Chiara Cugno (3441302)

"…<p>Rosiglitazone is an effective insulin-sensitizer, however associated with bone loss mainly due to increased bone resorption and bone marrow adiposity. …"

A novel design for battery cooling based on highly thermally conductive phase change composites encapsulated by 3D printed polyethylene/boron nitride layer حسب Safna Nishad (16932474)

"…Phase change materials (PCM) are increasingly studied for battery thermal management due to their passive thermal storage capacity and temperature homogeneity. …"

Epidemiological and genetic characterization of pH1N1 and H3N2 influenza viruses circulated in MENA region during 2009–2017 حسب Hebah A. Al Khatib (10494573)

"…Furthermore, nucleotide variations were lower at the antigenic sites of pH1N1 viruses compared to H3N2 viruses, which experienced higher variability at the antigenic sites, reflecting the increased immunological pressure because of longer circulation and continuous vaccine changes. …"

Double versus triple arthrodesis for adult-acquired flatfoot deformity due to stage III posterior tibial tendon insufficiency: a prospective comparative study of two cohorts حسب Amr A. Fadle (14150298)

"…The mean Hibbs angle decreased from 153.07 to 142.32° (MD = 10.54°, p < 0.001). …"

Inositol 1,4,5-Trisphosphate Receptors in Hypertension حسب Ali H. Eid (5461829)

"…Several lines of evidence implicate changes in expression/function levels of IP₃R isoforms in the development of hypertension, VSMC phenotypic switch, and vascular aging. …"

Helios Should Not Be Cited as a Marker of Human Thymus-Derived Tregs. Commentary: Helios+ and Helios− Cells Coexist within the Natural FOXP3+ T Regulatory Cell Subset in Humans حسب Eyad Elkord (5396390)

"…</p><p dir="ltr">Taken together, Helios expression confers stable phenotype of Tregs, and FoxP3⁺Helios⁺ Tregs have enhanced immunosuppressive characteristics, compared with FoxP3⁺Helios⁻ Tregs (8, 15). …"

The Immunophenotyping Changes of Peripheral CD4+ T Lymphocytes and Inflammatory Markers of Class III Obesity Subjects After Laparoscopic Gastric Sleeve Surgery – A Follow-Up Study... حسب Nasser M Rizk (18810328)

"…A control group of lean subjects was used to compare changes of T-regulatory and inflammatory biomarkers with postoperative changes in obese patients. </p><h3>Results </h3><p dir="ltr">The means (SD) of age and BMI of class III obesity subjects was 32.32 (8.36) years and 49.02 (6.28) kg/m², respectively. …"

Daucus carota Pentane-Based Fractions Suppress Proliferation and Induce Apoptosis in Human Colon Adenocarcinoma HT-29 Cells by Inhibiting the MAPK and PI3K Pathways حسب Shehaby, Wassim N.

"…Flow cytometric analysis indicated that both fractions induced sub-G1 phase accumulation and increased apoptotic cell death. Western blot revealed the activation of caspase-3, PARP cleavage, and a considerable increase in Bax and p53 levels, and a decrease in Bcl-2 level. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

An experimental and first principles DFT investigation on the effect of Cu addition to Ni/Al₂O₃ catalyst for the dry reforming of methane حسب Anjaneyulu Chatla (4888933)

"…DFT calculations reveal increased energy barrier for carbon adsorption, whilst promoting facile removal of deposited carbon. …"

Deciphering the In vitro Role of microRNAs miR-21-3p and miR-222-5p In the Regulation of Clostridioides difficile Flagellin-Induced Inflammation حسب Salman, Zeina

"…Western blot and pathway analyses demonstrated that miR-222-5p and miR-21-3p overexpression increased phosphorylation of p65, a key component of the NF-κB complex, while their knockdown reduced p65 phosphorylation. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Protein arginine methyltransferase 5 (PRMT5) activates WNT/β‐catenin signalling in breast cancer cells via epigenetic silencing of DKK1 and DKK3 حسب Harshita Shailesh (14779408)

"…Through chromatin immunoprecipitation (ChIP) studies, we found that PRMT5 binds to the promoter region of WNT antagonists, <i>DKK1</i> and <i>DKK3</i>, and induces symmetric methylation of H3R8 and H4R3 histones. …"

Mg-Doped PLA Composite as a Potential Material for Tissue Engineering—Synthesis, Characterization, and Additive Manufacturing حسب Fawad Ali (2154529)

"…In this study, we prepared and characterized a Mg/PLA composite as a potential material for direct ink writing (DIW) in 3D printing. The results showed that the addition of Mg has a significant impact on PLA’s thermal and structural properties and has also significantly increased the degradation of PLA. …"

Hydrodynamic Modelling of Sharjah lagoons (UAE) under Climate Changes حسب Singer, Mohamed Nashaat

احصل على النص الكامل

Stability enhancement of Al₂O₃, ZnO, and TiO₂ binary nanofluids for heat transfer applications حسب Ans Ahmed Memon (21633692)

"…X-ray diffraction and zeta potential were performed to characterize three nanoparticles, namely TiO₂, Al₂O₃, and ZnO. …"