A BRET-based Mpro biosensor containing a nanobody and tandem cleavage sites shows an increased cleavage rate حسب Geethakumari, Anupriya M

"…Live cell assays revealed a cleavage sequence length-dependent resonance energy transfer, except for the 12× -syn cleavage site, and an increased rate of cleavage and a decreased pharmacological inhibitor efficacy for the Mpro biosensor containing 2× cleavage sequences. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Reversal of memory and neuropsychiatric symptoms and reduced tau pathology by selenium in 3xTg-AD mice حسب Ann Van der Jeugd (18629695)

"…Chronic sodium selenate treatment efficiently reversed hippocampal-dependent learning and memory impairments, and behavior- and neuropsychiatric-like symptoms in old female 3xTg-AD mice. …"

Role of Edge Groups in Defining the Stability of Aromatic Molecules Under Electron Irradiation حسب Y. Tong (18394389)

"…Qualitative description of the experimental results is given through bond distance-dependent total energy calculations and structural and electronic structure analysis within density functional theory. …"

The Immunophenotyping Changes of Peripheral CD4+ T Lymphocytes and Inflammatory Markers of Class III Obesity Subjects After Laparoscopic Gastric Sleeve Surgery – A Follow-Up Study... حسب Nasser M Rizk (18810328)

"…</p><h3>Results </h3><p dir="ltr">The means (SD) of age and BMI of class III obesity subjects was 32.32 (8.36) years and 49.02 (6.28) kg/m², respectively. …"

Past and future climate effects on population structure and diversity of North Pacific surfgrasses حسب Ana I. Tavares (6942986)

"…Genetic diversity of <i>Phyllospadix torreyi </i>decreases from north to south, but in <i>Phyllospadix scouleri</i> the trend is variable. …"

The Effect of EVA and TPU Custom Foot Orthoses on Running Economy, Running Mechanics, and Comfort حسب Ken Van Alsenoy (14150559)

"…Both arch height (P = 0.06, η² = 0.19) and medio-lateral control (P = 0.06, η² = 0.16) showed a trend towards improved comfort for EVA and TPU vs CON. …"

Enhanced optical properties of <i>β</i>-Ga₂O₃-_<em>x</em>S_<em>x</em>S: A DFT study حسب G.B. Eshonqulov (22927297)

"…Consequently, the absorption intensity in the visible and UV ranges of the spectrum increases by more than an order of magnitude, depending on the level of doping, with a clear red shift. …"

Effect of surfactants on the convective heat transfer and pressure drop characteristics of ZnO/DIW nanofluids: An experimental study حسب Adnan Qamar (14421759)

"…The viscosity (VC) and thermal conductivity (TC) of NFs exhibited a strong dependence on the operating temperature and NFs concentration. …"

Finding novel targets for the treatment and reversal of type 2 diabetes mellitus and obesity حسب Imran Ramzan (15430807)

"…The present pilot study represents a novel dietary means by which to reduce BCAA, and as such, provides a blueprint for a potential dietary therapeutic in obesity/diabetes.…"

Stochastic Programming for Hub Energy Management Considering Uncertainty Using Two-Point Estimate Method and Optimization Algorithm حسب Ali S. Alghamdi (17541711)

"…Additionally, the results show that TPEM approach dependability consideration decreased hub energy’s profit by 8.995% as compared to deterministic planning.…"

Visible Light Photocatalytic Activity of Ag/WO₃ Nanoparticles and its Antibacterial Activity Under Ambient Light and in The Dark حسب Maha Matalkeh (17148358)

"…In addition, the catalyst shows high degradation efficiency and significant dose-dependent inhibition of Gram-negative E. Coli and the Gram-positive S. aureus. …"

The role of NF-κB and AhR transcription factors in lead-induced lung toxicity in human lung cancer A549 cells حسب Ibraheem M. Attafi (14151735)

"…Pb treatment induced oxidative stress by a) increasing the formation of reactive oxygen species and b) decreasing GSTA1 mRNA levels. The toxic effects of Pb on the lung was associated with significant increases in NF-κB and AhR levels which was accompanied with increases in downstream targets genes, iNOS and CYP1A1, respectively. …"

Exendin-4 alleviates steatosis in an in vitro cell model by lowering FABP1 and FOXA1 expression via the Wnt/-catenin signaling pathway حسب Olfa Khalifa (10914452)

"…Interestingly, the silencing of β-catenin with siRNA abolished the effect of Ex-4 on these genes, suggesting dependency on the Wnt/β-catenin pathway. Additionally, after β-catenin silencing, OA treatment significantly increased the expression of nuclear transcription factors SREBP-1 and TCF4, whereas Ex-4 significantly decreased this upregulation. …"

Algal-algal bioflocculation enhances the recovery efficiency of Picochlorum sp. QUCCCM130 with low auto-settling capacity حسب Imen Saadaoui (14159025)

"…Algal-algal bioflocculation efficiency is dependent on the ratio between species with different sizes, increasing with a higher proportion of larger size microalgal cells. …"

Evaluation and Enhancement of Triaging Services Through Quality Improvement Tools at Primary Health Care Level: A Clinical Audit Study حسب Ansif Pallath Majeed (17993848)

"…<h3>Background</h3><p dir="ltr">The effective and efficient operation of emergency services at healthcare depends on triage decisions. Successfully implementing a triage system improves patient care, communication, and self-assurance.…"

The Effects of Spirulina Supplementation on Cardiometabolic Risk Factors: A Narrative Review حسب Sara Sokary (17337724)

"…Spirulina was effective in reducing body weight, body mass index, and waist circumference, with a potential dose-dependent effect. It also decreased interleukin 6, an important biomarker of body inflammation, by inhibiting NADPH oxidase enzyme, and lowering insulin resistance. spirulina supplementation also reduced triglycerides, low-density lipoprotein cholesterol, and increased high-density lipoprotein cholesterol. …"

The investigation of treatment design parameters on carbon integration networks حسب Sabla Y. Alnouri (6331652)

"…However, there was a noticeable linear trend at lower temperatures compared to higher temperatures, where the increase became non-linear. …"

A Case Study in Qatar for Optimal Energy Management of an Autonomous Electric Vehicle Fast Charging Station with Multiple Renewable Energy and Storage Systems حسب Abdulla Al Wahedi (17115613)

"…This interest has focused mainly on reducing the reliance on fossil fuel-based means of transportation and decreasing the harmful emissions produced from this sector. …"

Wound healing potential of quercetin-3-O-rhamnoside and myricetin-3-O-rhamnoside isolated from Pistacia lentiscus distilled leaves in rats model حسب Wiem Elloumi (17148337)

"…Moreover, the cutaneous wound tissues treated with PDL 20, MM, and QM exhibited significantly higher hydroxyproline content than the negative control group, which means a high collagen biosynthesis in wound tissues. …"

Technical assessment of different extraction methods and transcriptome profiling of RNA isolated from small volumes of blood حسب Mahesh Kumar Reddy Kalikiri (17886695)

"…The quality of gene expression data is strictly dependent on the steps used for the sample collection, extraction, preparation and sequencing. …"