Decrease of muscle weakness and degeneration with mutants of UPS components. حسب Cécile Ribot (11944875)

Differential selection (diffsel) across Env upon remodeling of the host’s endoplasmic reticulum proteostasis network. حسب Jimin Yoon (9646685)

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Env net site diffsel is not correlated with surface accessible area (SAA). حسب Jimin Yoon (9646685)

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Enhanced mutational tolerance is observed more frequently at sites with high site entropy. حسب Jimin Yoon (9646685)

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Env sites with positive net site differential selection (diffsel) are clustered at the trimer apex. حسب Jimin Yoon (9646685)

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Upregulation of the host cell’s ER proteostasis environment generally reduces mutational tolerance across the Env protein sequence. حسب Jimin Yoon (9646685)

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Sequence logo plots reveal diffsel across Env upon induction of ATF6. حسب Jimin Yoon (9646685)

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Complete GSEA. حسب Jimin Yoon (9646685)

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Site entropy. حسب Jimin Yoon (9646685)

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Cumulative net site diffsel. حسب Jimin Yoon (9646685)

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RT-PCR of UPR genes upon transfection of Env variants. حسب Jimin Yoon (9646685)

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S4 Data. Library coverage - حسب Jimin Yoon (9646685)

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Complete RNA-Seq differential expression analysis. حسب Jimin Yoon (9646685)

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Surface accessible area. حسب Jimin Yoon (9646685)

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Primers for Env sequencing, RT-PCR, and site-directed mutagenesis. حسب Jimin Yoon (9646685)

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Immunoblot densitometric analysis. حسب Jimin Yoon (9646685)

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Complete citations for structural and functional groups. حسب Jimin Yoon (9646685)

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Resazurin assay and TZM-bl assay. حسب Jimin Yoon (9646685)

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Env variants with negative diffsel exhibit processing defects. حسب Jimin Yoon (9646685)

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Library coverage was generally consistent throughout the Env sequence. حسب Jimin Yoon (9646685)

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