Implementing CYP2C19 Pharmacogenetic Testing for Personalized Antiplatelet Therapy: Findings From the QPGx-CARES Initiative by Rania Abdel-latif (18295396)

“…<h3 dir="ltr">Purpose</h3><p dir="ltr">CYP2C19 loss-of-function (LoF) alleles are associated with increased cardiovascular risk in clopidogrel-treated percutaneous coronary intervention (PCI) patients. …”

Theoretical insight into effect of cation–anion pairs on CO₂ reduction on bismuth electrocatalysts by Sun Hee Yoon (7179263)

“…<p dir="ltr">This study presents theoretical insight into the mechanism of the CO₂ reduction reaction (CO₂RR) to formic acid (HCOOH) on Bi (0 1 2) surfaces in the presence of alkali metal cations (M⁺: Cs⁺, K⁺, and Li⁺) and/or halide anions (X⁻: Cl⁻, Br⁻, and I⁻) using density functional theory (DFT). The adsorption energy (Eads) and work function (Wf) of the anions increases with decreasing anion size (i.e., Cl⁻ > Br⁻ > I⁻). …”

Discovery of a novel cytokine signature for the diagnosis of autism spectrum disorder in young Arab children in Qatar by Wared Nour-Eldine (13904298)

“…</p><h3>Methods</h3><p dir="ltr">We measured the protein levels of 45 cytokines in the plasma samples of age- and gender-matched children (2–4 years) with ASD (n = 100) and controls (n = 60) using a Luminex multiplex assay. We compared the differences in the levels of these cytokines between the two study groups and then fitted the significantly altered cytokines into a logistic regression model to examine their diagnostic potential for ASD.…”

Methylomic profiling in trisomy 21 identifies cognition- and Alzheimer’s disease-related dysregulation by Larissa Haertle (3864310)

“…In view of the increased risk of developing AD in T21 individuals, we additionally investigated the T21-associated sites in published blood DNA methylation data from the AgeCoDe cohort (German study on Ageing, Cognition, and Dementia). …”

The effect of colchicine on myocardial infarction: An updated systematic review and meta-analysis of randomized controlled trials by Ayesha, Younas

“…However, all-cause mortality (RR = 1.00, 95 % CI: 0.72-1.39, P = 0.98, I2 = 0 %), incidence of cardiac arrest (RR = 0.81, 95 % CI: 0.33-1.95, P = 0.63, I2 = 0), incidence of stroke (RR = 0.45, 95 % CI: 0.17-1.19, P = 0.11, I2 = 36 %), incidence of recurrent MI (RR = 0.78, 95 % CI: 0.57-1.06, P = 0.11, I2 = 11 %) and the levels of hs-CRP (MD= -0.87, 95 %CI: -1.80-0.06, P=0.07, I2=67 % remained comparable across the two groups. ConclusionThe use of colchicine post-MI reduces the composite of adverse cardiovascular events, and hospitalization urgency but increases adverse gastrointestinal events. …”
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Novel proteins implicated in lipid metabolism disorders by Nature Research (16552612)

“…Genetic testing could be a useful source for identifying novel genetic causes of inherited lipoprotein disorders and could uncover new therapies to reduce lipid levels, he concludes.…”

Constructing a successful career in the Fourth Industrial Revolution for young graduates in the UAE by AHMED, AYMAN MOUSTAFA HANAFY

“…By examining the impacts of career competencies and career commitment components on subjective career success, the study also makes a useful contribution to the career success literature, which contains considerable ambiguity and contradictions. …”
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How does an imaginary persona's attractiveness affect designers' perceptions and IT solutions? An experimental study on users' remote working needs by Joni Salminen (7434770)

“…The personas' completeness, credibility, empathy, likability and usefulness increased with attractiveness. More attractive personas were also perceived as more agreeable, emotionally stable, extraverted and open, and the participants spent more time engaging with personas they perceived attractive. …”

The effects of Social Determinants of Health on Type 2 Diabetes Outcomes (A1C) by Awad, Nathalie

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Characterization of the Potency and Mechanism of Action of a Novel Dual-Selective Intermolecularly Complemented Version of Anthrax Lethal Toxin (PAU2R200A- PAL1I207R/FP59) in Breas... by Basala, Sobhiya

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Maternal–Neonatal Methylome Signatures In Preterm Birth Revealed By Long-Read DNA Methylation Profiling by BalaSubramani Gattu Linga (19325617)

“…Epigenetic regulation, particularly DNA methylation, is increasingly recognized as a key mediator of these processes, yet dual maternal-neonatal methylation landscapes in PTB remain insufficiently characterized. …”

Deletion of <i>RFX6</i> impairs iPSC-derived islet organoid development and survival, with no impact on PDX1⁺/NKX6.1⁺ progenitors by Noura Aldous (15429873)

“…Furthermore, RFX6 deficiency resulted in the formation of smaller islet organoids due to increased cellular apoptosis, linked to reduced catalase expression, implying a protective role for RFX6. …”

Epidemiological and genetic characterization of pH1N1 and H3N2 influenza viruses circulated in MENA region during 2009–2017 by Hebah A. Al Khatib (10494573)

“…</p><h3>Methods </h3><p dir="ltr">Analysis of phylogenetics and evolution of HA and NA genes was done using full HA and NA sequences (<i>n</i> = 1229) downloaded from Influenza Research Database (IRD). …”

The effect of colchicine on myocardial infarction: An updated systematic review and meta-analysis of randomized controlled trials by Ayesha Younas (7114868)

“…</p><h3>Conclusion</h3><p dir="ltr">The use of colchicine post-MI reduces the composite of adverse cardiovascular events, and hospitalization urgency but increases adverse gastrointestinal events. …”

Factors Affecting Internal Audit Effectiveness: Evidence from GCC Region by ABDELRAHIM, AYMAN ABDELLATIF

“…The role of the internal audit (IA) function in companies has evolved dramatically over the last two decades, and has become increasingly important to support audit committees and senior management. …”
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What’s So Great About Home? by Marroum, Marianne

“…Physically scattered all over Beirut, they moved intellectually in different circles and became increasingly feminist in their orientation.4 Other critics, such as Mona Amyuni, reject Cooke’s classification of al-Shaykh as a Beirut Decentrist because none of her works were written while in Lebanon. …”
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Mortality and associated risk factors of COVID-19 infection in dialysis patients in Qatar: A nationwide cohort study by Tarek Abdel Latif Ghonimi (16328413)

“…Univariate Cox regression analysis for risk factors associated with COVID-19-related death  in dialysis patients showed significant increases in risks with age (OR 1.077, CI 95%(1.018– 1.139), p = 0.01), CHF and COPD (both same OR 8.974, CI 95% (1.039–77.5), p = 0.046), history of DVT (OR 5.762, CI 95% (1.227–27.057), p = 0.026), Atrial fibrillation (OR 7.285, CI 95%(2.029–26.150), p = 0.002), hypoxia (OR: 16.6; CI 95%(3.574–77.715), p = <0.001), ICU admission (HR30.8, CI 95% (3.9–241.2), p = 0.001), Mechanical ventilation (HR 50.07 CI 95% (6.4–391.2)), p<0.001) and using inotropes(HR 19.17, CI 95% (11.57–718.5), p<0.001). …”