First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

“…Representative inhibitor <b>35m</b> exhibits potent HDAC6 inhibitory activity with an IC₅₀ value of 0.019 μM. To our surprise, <b>35m</b> establishes significant improvement in the pharmacokinetic property with much higher AUC_0‑inf (10292 ng·h/mL) and oral bioavailability (93.4%) than hydroximic acid-based HDAC6 inhibitors Tubastatin A and ACY-1215. …”

Fitting curve of rock E₅₀. by Junxia Zhou (14381598)

“…The research results indicate that: (1) As the rock bridge angle increases, the secant modulus gradually decreases, following a power function relationship. (2) As the rock size increases, the secant modulus shows a trend of first decreasing and then stabilizing, following a power function relationship. (3) As the rock bridge angle increases, the characteristic tangent modulus and characteristic size gradually decrease, following a power function relationship. …”

Image_3_Evidence for Decreased Density of Calretinin-Immunopositive Neurons in the Caudate Nucleus in Patients With Schizophrenia.TIF by Istvan Adorjan (8466846)

“…As expected, small, medium and large CR-ip interneurons were detected in the CN. We found a 38% decrease in the density of all CR-ip interneurons (P < 0.01) that was driven by the loss of the small CR-ip interneurons (P < 0.01) in patients with SCH. …”

Image_2_Evidence for Decreased Density of Calretinin-Immunopositive Neurons in the Caudate Nucleus in Patients With Schizophrenia.TIF by Istvan Adorjan (8466846)

“…As expected, small, medium and large CR-ip interneurons were detected in the CN. We found a 38% decrease in the density of all CR-ip interneurons (P < 0.01) that was driven by the loss of the small CR-ip interneurons (P < 0.01) in patients with SCH. …”

Image_5_Evidence for Decreased Density of Calretinin-Immunopositive Neurons in the Caudate Nucleus in Patients With Schizophrenia.TIF by Istvan Adorjan (8466846)

“…As expected, small, medium and large CR-ip interneurons were detected in the CN. We found a 38% decrease in the density of all CR-ip interneurons (P < 0.01) that was driven by the loss of the small CR-ip interneurons (P < 0.01) in patients with SCH. …”

Image_1_Evidence for Decreased Density of Calretinin-Immunopositive Neurons in the Caudate Nucleus in Patients With Schizophrenia.TIF by Istvan Adorjan (8466846)

“…As expected, small, medium and large CR-ip interneurons were detected in the CN. We found a 38% decrease in the density of all CR-ip interneurons (P < 0.01) that was driven by the loss of the small CR-ip interneurons (P < 0.01) in patients with SCH. …”

Image_4_Evidence for Decreased Density of Calretinin-Immunopositive Neurons in the Caudate Nucleus in Patients With Schizophrenia.TIF by Istvan Adorjan (8466846)

“…As expected, small, medium and large CR-ip interneurons were detected in the CN. We found a 38% decrease in the density of all CR-ip interneurons (P < 0.01) that was driven by the loss of the small CR-ip interneurons (P < 0.01) in patients with SCH. …”

Table_1_Evidence for Decreased Density of Calretinin-Immunopositive Neurons in the Caudate Nucleus in Patients With Schizophrenia.pdf by Istvan Adorjan (8466846)

“…As expected, small, medium and large CR-ip interneurons were detected in the CN. We found a 38% decrease in the density of all CR-ip interneurons (P < 0.01) that was driven by the loss of the small CR-ip interneurons (P < 0.01) in patients with SCH. …”

Image_7_Evidence for Decreased Density of Calretinin-Immunopositive Neurons in the Caudate Nucleus in Patients With Schizophrenia.TIF by Istvan Adorjan (8466846)

“…As expected, small, medium and large CR-ip interneurons were detected in the CN. We found a 38% decrease in the density of all CR-ip interneurons (P < 0.01) that was driven by the loss of the small CR-ip interneurons (P < 0.01) in patients with SCH. …”

Image_6_Evidence for Decreased Density of Calretinin-Immunopositive Neurons in the Caudate Nucleus in Patients With Schizophrenia.TIF by Istvan Adorjan (8466846)

“…As expected, small, medium and large CR-ip interneurons were detected in the CN. We found a 38% decrease in the density of all CR-ip interneurons (P < 0.01) that was driven by the loss of the small CR-ip interneurons (P < 0.01) in patients with SCH. …”

Image_2_Relative Diazotroph Abundance in Symbiotic Red Sea Corals Decreases With Water Depth.png by Arjen Tilstra (6915227)

“…We hypothesized that relative nifH gene copy numbers would decrease with water depth, assuming a related shift from autotrophy to heterotrophy. …”

Image_1_Relative Diazotroph Abundance in Symbiotic Red Sea Corals Decreases With Water Depth.tif by Arjen Tilstra (6915227)

“…We hypothesized that relative nifH gene copy numbers would decrease with water depth, assuming a related shift from autotrophy to heterotrophy. …”

DataSheet1_Decreased consumption of natural rewards in rhesus monkeys with prolonged methamphetamine abstinence.pdf by Jiahui Zhou (6106628)

IL-10 production in response to IL-27 is impaired in Chagas disease patients with severe cardiomyopathy. by María Ailén Natale (6843422)

The U937 cell line was seeded at 1 x 10⁵ cells per well. by Janani Madhuravasal Krishnan (19736002)

The U937 cell line was seeded at 2 x 10⁵ cells per well. by Janani Madhuravasal Krishnan (19736002)

Competitive binding experiment. by Deepu Dowarha (5673440)

NgR1 KO mice exhibited an increase in excitatory synapses and a decrease in inhibitory synapses, indicating an imbalance of synaptic transmission. by Jinwei Zhang (462455)

Example of skyline query for proteins. by Rizka Fatriani (17485787)

“…<i>paniculata</i> in treating obesity showed that there was a significant decrease in PPARG and EP300 gene expressions in 3T3-L1 mature adipocytes treated with <i>M</i>. …”

Top 10 pathways with the lowest p-value. by Rizka Fatriani (17485787)

“…<i>paniculata</i> in treating obesity showed that there was a significant decrease in PPARG and EP300 gene expressions in 3T3-L1 mature adipocytes treated with <i>M</i>. …”