Structure-Based Design of a Chemical Probe Set for the 5‑HT_5A Serotonin Receptor by Anat Levit Kaplan (12126567)

“…Docking over 6 million molecules against a 5-HT_5AR homology model identified 5 mid-μM ligands, one of which was optimized to <b>UCSF678</b>, a 42 nM arrestin-biased partial agonist at the 5-HT_5AR with a more restricted off-target profile and decreased assay liabilities versus SB-699551. …”

The influence of 5-HT in mice serum on <i>Plasmodium</i> infection in mosquitoes. by Li Gao (131516)

Total, free, and bound thrombin of 10,000 simulations of blood clotting over collagen/ TF under venous flow rate. by Jason Chen (15937)

Subjects:

Plasma protein levels and thrombin binding sites distribution of the subsets of top and bottom 2% of fibrin concentration of 10,000 simulations. by Jason Chen (15937)

Subjects:

SIINFEKL-specific CD8⁺ T cells treated with anti-CXCR3 decreased the polyfunctionality. by Camila Pontes Ferreira (6194006)

Genetic interaction of OPRM1 and 5-HT1a. by Jeanette Tour (10790855)

Fibrin concentration of 10,000 simulations compared to experimental data of blood clotting over collagen/ TF under venous flow rate. by Jason Chen (15937)

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Transient convection-diffusion of thrombin into and out of a fibrin domain exposed to venous flow. by Jason Chen (15937)

Subjects:

Decrease in cleavage score by randomly permuting string-of-beads vaccines. by Emilio Dorigatti (9558024)

“…<p>(a) For each vaccine in the Pareto frontier of each bootstrap, we created 50 new string-of-beads by randomly permuting its epitopes and compared the cleavage scores of the two vaccines. …”

Decreased Incidence of Type 1 Diabetes in Young Finnish Children by Anna Parviainen (9343391)

“…In the middle age group, a significant decrease was observed only among females. …”

Effect of 5-HT depletion on impact of satiation on error, RT, error pattern, and RT-error relationship. by Yukiko Hori (299784)

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Evidence of Formation of 1–10 nm Diameter Ice Nanotubes in Double-Walled Carbon Nanotube Capillaries by Yuan Liu (88411)

“…However, the single-walled INTs reported in the literature all possess subnanometer diameters (<1 nm). Herein, based on systematic and large-scale molecular dynamics simulations, we demonstrate the spontaneous freezing transition of liquid water to single-walled INTs with diameters reaching ∼10 nm when confined to capillaries of double-walled carbon nanotubes (DW-CNTs). …”

Evidence of Formation of 1–10 nm Diameter Ice Nanotubes in Double-Walled Carbon Nanotube Capillaries by Yuan Liu (88411)

“…However, the single-walled INTs reported in the literature all possess subnanometer diameters (<1 nm). Herein, based on systematic and large-scale molecular dynamics simulations, we demonstrate the spontaneous freezing transition of liquid water to single-walled INTs with diameters reaching ∼10 nm when confined to capillaries of double-walled carbon nanotubes (DW-CNTs). …”

Evidence of Formation of 1–10 nm Diameter Ice Nanotubes in Double-Walled Carbon Nanotube Capillaries by Yuan Liu (88411)

“…However, the single-walled INTs reported in the literature all possess subnanometer diameters (<1 nm). Herein, based on systematic and large-scale molecular dynamics simulations, we demonstrate the spontaneous freezing transition of liquid water to single-walled INTs with diameters reaching ∼10 nm when confined to capillaries of double-walled carbon nanotubes (DW-CNTs). …”

Evidence of Formation of 1–10 nm Diameter Ice Nanotubes in Double-Walled Carbon Nanotube Capillaries by Yuan Liu (88411)

“…However, the single-walled INTs reported in the literature all possess subnanometer diameters (<1 nm). Herein, based on systematic and large-scale molecular dynamics simulations, we demonstrate the spontaneous freezing transition of liquid water to single-walled INTs with diameters reaching ∼10 nm when confined to capillaries of double-walled carbon nanotubes (DW-CNTs). …”

Evidence of Formation of 1–10 nm Diameter Ice Nanotubes in Double-Walled Carbon Nanotube Capillaries by Yuan Liu (88411)

“…However, the single-walled INTs reported in the literature all possess subnanometer diameters (<1 nm). Herein, based on systematic and large-scale molecular dynamics simulations, we demonstrate the spontaneous freezing transition of liquid water to single-walled INTs with diameters reaching ∼10 nm when confined to capillaries of double-walled carbon nanotubes (DW-CNTs). …”

Selective TASK‑1 Inhibitor with a Defined Structure–Activity Relationship Reduces Cancer Cell Proliferation and Viability by Bárbara Arévalo (4053358)

“…Mutation of seven residues to A (I118A, L122A, F125A, Q126A, L232A, I235A, and L239A) markedly decreased the F3-induced inhibition of TASK-1 channels, consistent with the molecular modeling predictions. …”

Selective TASK‑1 Inhibitor with a Defined Structure–Activity Relationship Reduces Cancer Cell Proliferation and Viability by Bárbara Arévalo (4053358)

“…Mutation of seven residues to A (I118A, L122A, F125A, Q126A, L232A, I235A, and L239A) markedly decreased the F3-induced inhibition of TASK-1 channels, consistent with the molecular modeling predictions. …”

Effects of 5-HTR blockade on incentive. by Yukiko Hori (299784)

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K562 cells were treated with 40 nM of miR-214 mimics or a negative mimics control for 24 h, followed by treatment with 50 μM of hemin for 48 h. by Tipparat Penglong (164413)