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Rdh10a deficient embryos have decreased expression of RA signaling responsive genes.
Published 2015“…<p>(A-F) ISH for <i>cyp26a1</i>, <i>hoxb5b</i>, <i>and dhrs3a</i> expression in control sibling and Rdh10a deficient embryos. …”
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CsA reduces Flk1 protein expression and significantly decreases the percentages of Flk1+ cells.
Published 2015“…(C) Representative flow cytometry profiles showing the decreased percentages of Flk1+ cells in P19 cells treated with 0.32 μM CsA during EB formation for 48 and 96 h, respectively. …”
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COVID-19 incidence increases over time with a decreased importance of genetic COVID-19 susceptibility.
Published 2022“…<p>a) Kaplan-Meier curve stratified by genetic risk for COVID-19 infections. b) Fitted logistic longitudinal model for COVID-19 shows increasing infections regardless of genetic risk. …”
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Processive receptor methylation compromises adaptation and decreases signaling noise.
Published 2013“…The model was exposed to simulated time-varying exponential ramps of methyl-aspartate and the resulting steady-state activity <i>a</i><sub>0</sub> recorded (black). (B) Response to small (5 µM) and large (1 mM) MeAsp step stimulus at applied at <i>t</i> = 200 s as measured by receptor activity <i>a</i>(<i>t</i>). …”