Showing 201 - 220 results of 43,329 for search '(((( 2 c decrease ) OR ( 50 ((we decrease) OR (nn decrease)) ))) OR ( 2012 mean decrease ))', query time: 0.77s Refine Results
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    Design, Synthesis, and Biological Evaluation of [1,2,5]Oxadiazolo[3,4‑<i>b</i>]pyridin-7-ol as Mitochondrial Uncouplers for the Treatment of Obesity and Metabolic Dysfunction-Assoc... by Mary A. Foutz (20361830)

    Published 2024
    “…Utilizing an oxygen consumption rate assay as a measure of increased cellular respiration, <b>SHO1122147</b> (<b>7m</b>) displayed an EC<sub>50</sub> of 3.6 μM in L6 myoblasts. Pharmacokinetic studies indicated a half-life of 2 h, <i>C</i><sub>max</sub> of 35 μM, and no observed adverse effects at 1,000 mg kg<sup>–1</sup> dose in mice. …”
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    Image_3_Decreased Colonic Guanylin/Uroguanylin Expression and Dried Stool Property in Mice With Social Defeat Stress.tif by Nobuhiko Ebisutani (9764468)

    Published 2020
    “…The expression of GN, UGN, and guanylate cyclase 2C in the colonic tissues was examined by real-time RT-PCR and immunohistochemistry. …”
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    Image_1_Decreased Colonic Guanylin/Uroguanylin Expression and Dried Stool Property in Mice With Social Defeat Stress.TIF by Nobuhiko Ebisutani (9764468)

    Published 2020
    “…The expression of GN, UGN, and guanylate cyclase 2C in the colonic tissues was examined by real-time RT-PCR and immunohistochemistry. …”
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    Design and Synthesis of Novel Spiro Derivatives as Potent and Reversible Monoacylglycerol Lipase (MAGL) Inhibitors: Bioisosteric Transformation from 3‑Oxo-3,4-dihydro‑2<i>H</i>‑ben... by Shuhei Ikeda (2380180)

    Published 2021
    “…Optimization of the left hand side afforded <b>4f</b> as a promising reversible MAGL inhibitor, which showed potent in vitro MAGL inhibitory activity (IC<sub>50</sub> 6.2 nM), good oral absorption, blood–brain barrier penetration, and significant pharmacodynamic changes (2-arachidonoylglycerol increase and arachidonic acid decrease) at 0.3–10 mg/kg, po. in mice.…”