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The rate of lariat formation is decreased two-fold by isoginkgetin treatment.
Published 2014“…RNA-Seq density is normalized as read counts per 10M uniquely aligning reads. The indicated values are from an average of three biological replicates, and <i>p</i>-values are from two-tailed <i>t</i>-tests based on mean values for aggregated introns 2–10 (n = 9). …”
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Resveratrol decreases PKM2 expression.
Published 2013“…<p>Resveratrol treatment decreases PKM2 mRNA in (A), HeLa; (B), HepG2 and (C), MCF-7; by approximately two-folds. β-actin was taken as endogenous control and normalized to PKM2 mRNA. …”
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TUDCA decreases ER stress in HOX neonatal rat lungs.
Published 2022“…(<b>B</b>) TUDCA also decreases ER stress-mediated apoptosis as evidenced by the decreased CHOP (0.6±0.1-fold, p = 0.002001, n = 5), caspase-12 (0.7±0.1-fold, p<0.001, n = 5), cleaved caspase-12 (0.6±0.1-fold, p<0.001, n = 5), and BAX/BCl<sub>2</sub> ratio (0.2±0.0-fold, p<0.001, n = 5). …”
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Molecular and Structural Analysis of Mosaic Variants of Penicillin-Binding Protein 2 Conferring Decreased Susceptibility to Expanded-Spectrum Cephalosporins in <i>Neisseria gonorrh...
Published 2010“…Transfer of the mosaic <i>penA35</i> allele containing an A501V mutation to FA6140, a chromosomally mediated penicillin-resistant isolate, increased the MICs of ceftriaxone (0.4 μg/mL) and cefixime (1.2 μg/mL) to levels above their respective break points. …”
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mGluR5 receptor decreased glycinergic currents.
Published 2019“…CHPG, α-amino-2-chloro-5-hydroxybenzeneacetic acid; DHPG, (S)-3,5-Dihydroxyphenylglycine; GABA<sub>A</sub> receptor, γ-Aminobutyric acid type A receptor; GDP-β-S, Guanosine 5ʹ-O-(2-Thiodiphosphate); GlyR, glycine receptor; IPSC, inhibitory postsynaptic current; mGluR5, metabotropic glutamate receptor 5; MPEP, 6-Methyl-2-(phenylethynyl) pyridine; PD98059, 2ʹ-Amino-3ʹ-methoxyflavone; Ro-32-0432, 2-{8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-3-yl}-3-(1-methyl-1H-indol-3-yl)maleimide.…”
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Relationship between Differential Hepatic microRNA Expression and Decreased Hepatic Cytochrome P450 3A Activity in Cirrhosis
Published 2013“…Notably, miR-155, a known regulator of liver inflammation, had the highest fold increase in cirrhotic livers (2.2-fold, P=4.16E-08) and significantly correlated with hepatic CYP3A activity (r=-0.50, P=0.017). …”
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Transaldolase deficiency causes a starvation-like response that decreases animal fat content and rewires lipid metabolism gene expression.
Published 2017“…<b>(G)</b> Gene expression of starvation-responsive lipid metabolism genes is altered in <i>tald-1(RNAi)</i> animals. Log2 fold change calculated to emphasize the increases and decreases in gene expression levels from RNAi treatments (N = 6–8 independent experiments, error bars indicate s.e.m., paired student’s t-tests with Bonferroni’s correction). …”
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Exposure to EtBr decreases mtRNA in rat striatal co-cultures, purified neuronal cultures, and astrocytes.
Published 2017“…<p>(A-C) Log2-fold decrease in mtRNA expression after EtBr treatment assayed with RNASeq, in (A) NECos, (B), pure neuronal cultures, and (C) astrocytes. …”
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Downregulation of DOM decreases the abundance of PER and TIM.
Published 2019“…Downregulation of <i>dom</i> decreased <i>per</i> and <i>tim</i> mRNA levels (middle and right panels), while <i>clk</i> was normal (left panel). …”