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The rate of lariat formation is decreased two-fold by isoginkgetin treatment.
Published 2014“…The height of each bar indicates the fold change, from vehicle- to isoginkgetin-treated cells, in the mean fraction of reads aligning to each genic feature (<i>p</i><0.02 from two-tailed <i>t</i>-tests for all ratios). …”
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Resveratrol decreases PKM2 expression.
Published 2013“…<p>Resveratrol treatment decreases PKM2 mRNA in (A), HeLa; (B), HepG2 and (C), MCF-7; by approximately two-folds. β-actin was taken as endogenous control and normalized to PKM2 mRNA. …”
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Relationship between Differential Hepatic microRNA Expression and Decreased Hepatic Cytochrome P450 3A Activity in Cirrhosis
Published 2013“…Notably, miR-155, a known regulator of liver inflammation, had the highest fold increase in cirrhotic livers (2.2-fold, P=4.16E-08) and significantly correlated with hepatic CYP3A activity (r=-0.50, P=0.017). …”
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Transaldolase deficiency causes a starvation-like response that decreases animal fat content and rewires lipid metabolism gene expression.
Published 2017“…<b>(J)</b> RNAi knockdown of <i>tald-1</i> does not require NHR-49 for lifespan extension. N2 fed <i>EV(RNAi)</i> (mean 17.5±0.1 days, n = 366), N2 fed <i>tald-1(RNAi)</i> (mean 20.1±0.1 days, n = 397), <i>nhr-49(nr2041)</i> fed <i>EV(RNAi)</i> (mean 11.5±0.1 days, n = 310), <i>nhr-49(nr2041)</i> fed <i>tald-1(RNAi)</i> (mean 12.9±0.1 days, n = 333). …”
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TMD residues decrease sensitivity.
Published 2017“…Glu residues are color coded based upon effect, with residues in red producing a significant decrease in pH<sub>50</sub>, and in yellow, an insignificant or weak effect, whereas the dark purple and magenta for His residues are synonymous to the red of Glu residues. …”
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FTY720 decreased viability, proliferation, and motility and induced apoptosis in human hepatoblastoma cells.
Published 2019“…<p>(A) Following 24 hours of treatment with FTY720, the viability of HuH6 cells measured using the alamarBlue cell viability assay was significantly decreased (LD<sub>50</sub> = 8.4 μM, p ≤ 0.05). …”
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BMT decreased weight of different organs.
Published 2017“…(B) Linear regression analysis of pancreas weight and body weight showed a lower pancreas weight in the BMT-treated mice, independently of body weight. Values are means ± SD; n = 7–12; * p<0.05, ** p<0.01, *** p<0.001.…”
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