Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

SARS-CoV-2-specific CD4 and cTfh responses decrease in magnitude in late convalescence. by Sushma Boppana (7181300)

Significantly decreased adhesion to host cells by the Δ<i>tad123</i> mutant (A) and time-dependent recovery (B). by Tra-My Duong-Nu (7300970)

Su(H) and RBPJ AOS variants decrease DNA binding. by Ellen K. Gagliani (11478756)

The AMPK inhibitor CC exacerbates palmitate-induced decreases in viability. by Dustin M. Lee (8207457)

Inhibition of ABCG2 decreases SP cells, but not sphere-forming ability. by Noriko Kawai (6694010)

Oxytocin decreases postsynaptic CeA spontaneous GABAergic transmission and blocks presynaptic alcohol effects. by Brendan J. Tunstall (6593357)

“…(C) Representative sIPSCs of CeA neurons from nondependent (Left) and dependent (Right) rats before and during application of alcohol (44 mM), oxytocin (500 nM), and oxytocin with alcohol. …”

CaMKKβ contributes to the decrease in apoptosis conferred by ST2-104. by Yingshi Ji (9013004)

CaMKKβ is involved in ST2-104-regulated decrease in autophagy. by Yingshi Ji (9013004)

Dcp1a protein levels are decreased by KapB expression and Torin treatment. by Carolyn-Ann Robinson (13297009)

Comparison of mean differences in temperature decreases. by Hans-Jörg Gillmann (8460585)

Subjects:

A nonsense mutation in <i>anmK</i> contributes to decreased growth of AC811 in Arabidopsis leaves. by Megan R. O’Malley (7485323)

Data Figs 4B, 5A, 5B, 5C and 5D. by Mona Estrella Bachmann (13531933)

HAstV-1 infection leads to a time-dependent decrease in junctional protein levels. by Virginia Hargest (12447014)

Comparison of SF-36 scores of participants with residual limb pain with a VAS score ≥5 and participants with a VAS score <5. by Martin C. Berli (9427264)

The saturated fatty acid palmitate decreases viability and induces apoptosis in HUVECs. by Dustin M. Lee (8207457)

Cellular uptake of [¹⁴C]docosahexaenoic acid (DHA) by RBECs transfected with MFSD2A siRNA. by Takuro Iwao (14636741)

Subjects:

App1 decreases the recovery time after amphotericin B treatment. by Muhammad Ghaffar (8082002)

Met decreases MYH1/2 and p21 expression and increases Myf5 and MyoD levels in myotubes. by Eleonora Maniscalco (14599854)