Synthesis and Antiproliferative Activity of a New Series of Mono- and Bis(dimethylpyrazolyl)‑<i>s</i>‑triazine Derivatives Targeting EGFR/PI3K/AKT/mTOR Signaling Cascades by Ihab Shawish (13015516)

Subjects:

Structure–Activity Studies of 1<i>H</i>‑Imidazo[4,5‑<i>c</i>]quinolin-4-amine Derivatives as A₃ Adenosine Receptor Positive Allosteric Modulators by Lucas B. Fallot (14106171)

Subjects:

Structure–Activity Studies of 1<i>H</i>‑Imidazo[4,5‑<i>c</i>]quinolin-4-amine Derivatives as A₃ Adenosine Receptor Positive Allosteric Modulators by Lucas B. Fallot (14106171)

Subjects:

SARS-CoV‑2 Delta Variant Decreases Nanobody Binding and ACE2 Blocking Effectivity by Mert Golcuk (10789806)

SARS-CoV-2 inhibits SG formation and decreases expression of G3BP1. by Stacia M. Dolliver (13822801)

Prepulse Inhibition (PPI) of acoustic startle response decreased two months after repeated chlorpyrifos daily doses. by Shannon H. Romer (14297822)

Stromal TIL quantification by H&E (n = 12). by Ting-Fang He (5210948)

Skp2 inhibitor SKPin C1 decreased viability and proliferation of multiple myeloma cells and induced apoptosis by Ying Yang (24175)

“…In contrast, 50 μM SKPin C1 only marginally decreased viability of normal B lymphocytes in 12 h. …”

Source data for Figs 1E, 2E, 2G, 3B, 3D, 3H, 5D, 6B, 6E, 7B, 7E, S1A, S1B, S1C, S3B, S4, S5B, S5D, S6, S7B, S7D, S10B, S10C, S11B, S11C, S12B, and S12D. by Yongle Zhang (11355546)

GSK343 decreased neuroblastoma viability, proliferation, and motility. by Laura V. Bownes (10276762)

“…<p>(A) SK-N-AS, SK-N-BE(2), SH-EP and WAC(2) cells (1.5 × 10³ cells) were treated with increasing concentrations of GSK343 (0, 5, 15, 25 μM) for 24 hours and viability was measured using alamarBlue^® assay. …”

IMP-1088 decreases infectivity of progeny VACV particles. by Lalita Priyamvada (421536)

Cell proliferation was decreased more by combination treatment of SLCP and BBR than individual treatments. by Panchanan Maiti (1459852)

Cyp and transporter gene expression in liver and kidney of 12-week-old hCYP3A4 mice. by Kavya Annu (11587215)

Inclusion of TPP side chains result in decreased melanoma cell mitochondria membrane potential, oxygen consumption, and increased DHE oxidation. by Kyle C. Kloepping (9928265)

“…(C) A375 melanoma cells were treated with 1.0 μM 5-, 8-, 10-, 12-,14-, or 16-TPP for 1.5 h and analyzed for DHE oxidation (* significant relative to control; p<0.05; n = 3 from 2 separate experiments; N = 6). …”

Supplementary Figure 5 from Advanced Age Increases Immunosuppression in the Brain and Decreases Immunotherapeutic Efficacy in Subjects with Glioblastoma by Erik Ladomersky (15027230)

Predictions of random forests (RF), gradient boosting machines (GBM), and neural networks (NN) trained on 17 covariates selected after recursive feature selection. by Dennis Ochola (11626912)

Bacterial load in lung and spleen of binge-drinking mice intranasally infected with decreasing doses of <i>B</i>. <i>thailandensis</i>. by Victor M. Jimenez Jr. (8107853)

Comparison of the MMP in HL-1 cells exposed to LG, NG, HG and IHG between short- (12h) and long-time (72h) glucose treatment. by Patrick Mordel (17020879)

Distribution Coefficients of the REEs, Sr, Y, Ba, Th, and U between α‑HIBA and AG50W-X8 Resin by Haoyu Li (1672648)

“…However, only limited REE partition data between α-HIBA and cation resins exist, which makes it challenging to develop and optimize purification techniques using this platform. Here, we report distribution coefficients (<i>K</i>_d) of REEs, as well as Sr, Y, Ba, Th, and U, between α-HIBA at pH = 4.50 and AG50W-X8 cation-exchange resin, obtained by batch equilibration experiments. …”

Global Land Use Change Impacts on Soil Nitrogen Availability and Environmental Losses by Jing Wang (6206297)

“…By compiling a global data set of 1,782 paired observations from 185 publications, we show that land use conversion from natural to managed ecosystems significantly reduced NNM by 7.5% (−11.5, −2.8%) and increased NN by 150% (86, 194%), indicating decreasing N availability while increasing potential N loss through denitrification and nitrate leaching. …”