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Image_5_Consecutive Hypoxia Decreases Expression of NOTCH3, HEY1, CC10, and FOXJ1 via NKX2-1 Downregulation and Intermittent Hypoxia-Reoxygenation Increases Expression of BMP4, NOT...
Published 2020“…In both the normal and diseased HBE cells, intermittent H/R significantly increased HIF1A, BMP4, NOTCH1, MKI67, OCT4, and MUC5AC expression, while consecutive hypoxia significantly decreased NKX2-1, NOTCH3, HEY1, CC10, and FOXJ1 expression. …”
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GCase activity is significantly decreased in the brain and liver of the homozygous <i>GBA1</i> D409V KI mouse model at 4, 8, and 12 months of age.
Published 2021“…In whole brain homogenate (A,C) and liver homogenate (B,D), GCase activity is significantly decreased in the <i>GBA1</i> D409V KI homozygous (HOM) mice as compared to C57Bl/6 wild type (WT) mice (n = 7/group). …”
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Design, Synthesis, and Biological Evaluation of [1,2,5]Oxadiazolo[3,4‑<i>b</i>]pyridin-7-ol as Mitochondrial Uncouplers for the Treatment of Obesity and Metabolic Dysfunction-Assoc...
Published 2024“…Pharmacokinetic studies indicated a half-life of 2 h, <i>C</i><sub>max</sub> of 35 μM, and no observed adverse effects at 1,000 mg kg<sup>–1</sup> dose in mice. …”
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Incidence and fitting values of Hepatitis predicted by three neural network models.
Published 2022Subjects: -
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The <i>rcan-1</i> rearrangement allele decreases expression of <i>rcan-1</i>.
Published 2020“…Scale bar is 50μm. (A: anterior; P: posterior).</p>…”