بدائل البحث:
ht decrease » _ decrease (توسيع البحث), we decrease (توسيع البحث), step decrease (توسيع البحث)
nn decrease » _ decrease (توسيع البحث), mean decrease (توسيع البحث), gy decreased (توسيع البحث)
nm decrease » _ decrease (توسيع البحث), we decrease (توسيع البحث), gy decreased (توسيع البحث)
a decrease » _ decrease (توسيع البحث), _ decreased (توسيع البحث), _ decreases (توسيع البحث)
5 ht » 5 h (توسيع البحث)
5 nm » 5 mm (توسيع البحث), 5 cm (توسيع البحث)
ht decrease » _ decrease (توسيع البحث), we decrease (توسيع البحث), step decrease (توسيع البحث)
nn decrease » _ decrease (توسيع البحث), mean decrease (توسيع البحث), gy decreased (توسيع البحث)
nm decrease » _ decrease (توسيع البحث), we decrease (توسيع البحث), gy decreased (توسيع البحث)
a decrease » _ decrease (توسيع البحث), _ decreased (توسيع البحث), _ decreases (توسيع البحث)
5 ht » 5 h (توسيع البحث)
5 nm » 5 mm (توسيع البحث), 5 cm (توسيع البحث)
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Table_1_Sub-Acute Treatment of Curcumin Derivative J147 Ameliorates Depression-Like Behavior Through 5-HT1A-Mediated cAMP Signaling.DOCX
منشور في 2020"…Background<p>Major depressive disorder (MDD) is a severe mental disorder related to the deficiency of monoamine neurotransmitters, particularly to abnormalities of 5-HT (5-hydroxytryptamine, serotonin) and its receptors. …"
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Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance...
منشور في 2021"…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo[1,5-<i>a</i>]pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC<sub>50</sub> = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …"
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Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance...
منشور في 2021"…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo[1,5-<i>a</i>]pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC<sub>50</sub> = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …"
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Oxytocin decreases postsynaptic CeA spontaneous GABAergic transmission and blocks presynaptic alcohol effects.
منشور في 2019"…<p>(A, Top) Representative GABA<sub>A</sub>-mediated sIPSCs of CeA neurons from nondependent and dependent rats prior to (baseline) and during application of oxytocin (500 nM). …"
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5.HT<sub>1A</sub> binding difference between known cause of death (KCOD) controls and SIDS.
منشور في 2025"…When SIDS is compared to all KCOD controls, the HG, NTS, and MAO show a significant mean difference in 5-HT<sub>1A</sub> receptor binding. …"
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Data_Sheet_1_Determining 5HT7R’s Involvement in Modifying the Antihyperalgesic Effects of Electroacupuncture on Rats With Recurrent Migraine.pdf
منشور في 2021"…<p>Electroacupuncture (EA) is widely used in clinical practice to relieve migraine pain. 5-HT<sub>7</sub> receptor (5-HT<sub>7</sub>R) has been reported to play an excitatory role in neuronal systems and regulate hyperalgesic pain and neurogenic inflammation. 5-HT<sub>7</sub>R could influence phosphorylation of protein kinase A (PKA)- or extracellular signal-regulated kinase<sub>1</sub><sub>/</sub><sub>2</sub> (ERK<sub>1</sub><sub>/</sub><sub>2</sub>)-mediated signaling pathways, which mediate sensitization of nociceptive neurons via interacting with cyclic adenosine monophosphate (cAMP). …"
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The decrease or inhibition of Hsp90 induced REST degradation.
منشور في 2019"…<p>(A) Effect of Hsp90α ASO on cell viability. Differentiated SH-SY5Y cells were transfected with different concentrations of Hsp90α ASO. …"
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Data_Sheet_1_5-HT1A Receptor Agonist Promotes Retinal Ganglion Cell Function by Inhibiting OFF-Type Presynaptic Glutamatergic Activity in a Chronic Glaucoma Model.docx
منشور في 2019"…In addition, the high expression of GS and EAAT2 induced by glaucoma was downregulated by the 5-HT1A receptor agonist 8-OH-DPAT and the 5-HT1A receptor antagonist WAY-100635, respectively. …"
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Image1_The serotonin receptor 5-HT2A modulates lifespan and protein feeding in Drosophila melanogaster.pdf
منشور في 2022"…Loss of the 5-HT2A receptor extends lifespan and induces a resistance to changes in dietary protein that are normally detrimental to lifespan. 5-HT2A<sup>−/−</sup> null mutant flies also display decreased protein feeding and protein content in the body. …"
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Image2_The serotonin receptor 5-HT2A modulates lifespan and protein feeding in Drosophila melanogaster.pdf
منشور في 2022"…Loss of the 5-HT2A receptor extends lifespan and induces a resistance to changes in dietary protein that are normally detrimental to lifespan. 5-HT2A<sup>−/−</sup> null mutant flies also display decreased protein feeding and protein content in the body. …"
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Image3_The serotonin receptor 5-HT2A modulates lifespan and protein feeding in Drosophila melanogaster.pdf
منشور في 2022"…Loss of the 5-HT2A receptor extends lifespan and induces a resistance to changes in dietary protein that are normally detrimental to lifespan. 5-HT2A<sup>−/−</sup> null mutant flies also display decreased protein feeding and protein content in the body. …"
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