Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... حسب Shuai Wang (109515)

"…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …"

Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... حسب Shuai Wang (109515)

"…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …"

Positional cloning of <i>qNN1</i> on chromosome 16. حسب Xinxin Li (281237)

Dox-inducible expression of HA-MAD1 in colon is sufficient to decrease p53 expression and cause chromosome missegregation. حسب Sarah E. Copeland (13951506)

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Sonication decreases toxicity of the Vicilin, Cupin-1.1, and Cupin-1.2 fibrils. حسب Kirill S. Antonets (4807410)

WT1 siRNA decreases proliferation, pAKT, and Bcl2 expression. حسب Ayana E. Morales (17756335)

"…Corresponding densitometry analysis is noted as protein fold expression compared to GAPDH for WT1, p<0.001(***), vFLIP(ns), LANA p<0.05(*), pAKT p<0.05(*), and BCL2 p <0.05(*) using two-sided, unpaired student t-tests. …"

Oxytocin decreases postsynaptic CeA spontaneous GABAergic transmission and blocks presynaptic alcohol effects. حسب Brendan J. Tunstall (6593357)

"…<p>(A, Top) Representative GABA_A-mediated sIPSCs of CeA neurons from nondependent and dependent rats prior to (baseline) and during application of oxytocin (500 nM). …"

Genes with a log2 fold-change > 5 in the LPS, IFNγ, LPS+IFNγ datasets not present in the IL-4 dataset. حسب Giorgia Colombo (6337118)

The decrease or inhibition of Hsp90 induced REST degradation. حسب Raúl Orozco-Díaz (7067624)

"…<p>(A) Effect of Hsp90α ASO on cell viability. Differentiated SH-SY5Y cells were transfected with different concentrations of Hsp90α ASO. …"

Pyrimidine nucleotides are decreased in hypoxia, while precursors accumulate. حسب Emily B. Cohen (9106088)

Foldases and holdases each decrease the level of unfolded protein. حسب Adam MR de Graff (9767829)

Bortezomib decreases osteoclasts and improves fracture repair in mice. حسب Hengwei Zhang (2397610)

MigC interacts with and decreases the activity of MurD. حسب Jeanette M. Critchlow (21553796)

Transcription of a plasmid-borne copy of the <i>mgtC</i> gene from a heterologous promoter reduces protein synthesis. حسب Carissa Chan (18310140)

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Fold change in humoral and cellular response magnitudes from RV305 week 2 to week 26. حسب LaTonya D. Williams (3140490)

Dysfunction of <i>ERG251</i> activates a Zinc transporter contributing to decreased azole susceptibility. حسب Xin Zhou (54275)

Retinoic acid decreases intracellular K⁺ in pectoral fin buds via transcriptional activation of the calcineurin inhibitor <i>rcan2</i>. حسب Xiaowen Jiang (8291814)

Dcp1a protein levels are decreased by KapB expression and Torin treatment. حسب Carolyn-Ann Robinson (13297009)

Propagation of an action potential through ephaptic coupling is achieved for a decreased extracellular conductivity. حسب Karoline Horgmo Jæger (6785450)

<i>dnak14</i> mutant harbors a transposon insertion in the <i>dnaK</i> coding region and specifies a truncated DnaK protein. حسب Carissa Chan (18310140)

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