Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

Gating properties of <i>CACNA1I</i> variants with pooled WT data. by Yousra El Ghaleb (22075892)

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Klf5 deficiency leads to mitochondrial dyfunction in VSMCs. by Dong Ma (584680)

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Loss of nsp14-ExoN activity decreases recombination frequency and alters recombination junction patterns across the genome. by Jennifer Gribble (10005444)

HDM-induced chronic airway inflammatory cytokines decreased in TSLPR deficient mice. by Latifa Koussih (326043)

SMC-specific knockout of Klf5 (smcKlf5^−/−) exacerbates the progression of Ang II–induced AAA by facilitating ROS formation. by Dong Ma (584680)

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200 WT nts but not WT UTRs at each terminus are sufficient for efficient recovery of replicating virus. by Debarpan Dhar (724473)

Fig 5 - by Xiajun Zhang (3161865)

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Klf5 deficiency in mouse VSMCs leads to mitochondrial fission. by Dong Ma (584680)

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Palmitic acid decreases cell migration by increasing RGS2 expression and decreasing SERCA expression by Octavio Galindo-Hernandez (10350992)

eIF5a interacts with Mfn1 and preserves mitochondrial integrity. by Dong Ma (584680)

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The correlation of the mitochondrial dynamics–related genes with Klf5 in mouse VSMCs. by Dong Ma (584680)

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Metformin decreases CRC-like organoids viability to the same extent as current chemotherapy without significant effects on WT organoids. by Silvia Cruz-Gil (7037249)

Image 5_G. vaginalis increases HSV-2 infection by decreasing vaginal barrier integrity and increasing inflammation in vivo.tif by Nuzhat Rahman (16660416)

“…</p>Methods<p>Mice were inoculated with 10⁷ CFU of the eubiotic bacteria Lactobacillus crispatus, the dysbiotic bacteria G. vaginalis, or PBS as a negative control every 48 h for ten days. On day ten, mice were inoculated with 10⁵ PFU WT HSV-2 333 and survival, pathology, and viral titers were assessed. …”

DataSheet_1_Hepatic-Specific Decrease in the Expression of Selenoenzymes and Factors Essential for Selenium Processing After Endotoxemia.docx by Laura G. Sherlock (9602411)

“…</p>Methods<p>Wild type (WT) adult male C57/B6 mice were exposed to LPS (5 mg/kg, intraperitoneal). …”

Bacterial intracellular survival increases <i>in vivo</i> persistence in a mouse model of urinary tract infection and decreases antibiotic efficacy. by Cristina Penaranda (433703)

Results isoprenaline (30nM) experiment. by L. Cao (3526226)

S5 Fig - by Cynthia Alsayyah (18452506)

“…This indicates that inhibiting the entry of citrate into mitochondria induces the same effects as inhibiting the synthesis of peroxisomal citrate (see <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002602#pbio.3002602.g005" target="_blank">Fig 5E</a>). …”

Functional Plasmonic Microscope: Characterizing the Metabolic Activity of Single Cells via Sub-nm Membrane Fluctuations by Suraj D. Khochare (18288990)

“…A low-concentration dose showed a reduced fluctuation frequency with consistent fluctuation amplitudes, while the high-concentration dose showcased a decreasing trend in both cases. …”

Functional Plasmonic Microscope: Characterizing the Metabolic Activity of Single Cells via Sub-nm Membrane Fluctuations by Suraj D. Khochare (18288990)

“…A low-concentration dose showed a reduced fluctuation frequency with consistent fluctuation amplitudes, while the high-concentration dose showcased a decreasing trend in both cases. …”