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    Discovery of Novel Acridane-Based Tubulin Polymerization Inhibitors with Anticancer and Potential Immunomodulatory Effects by Xiaopeng Peng (9136955)

    Published 2022
    “…The most potent compound <b>NT-6</b> exhibited high tubulin polymerization inhibitory activity (IC<sub>50</sub> = 1.5 μM) and remarkable antiproliferative potency against four cancer cell lines with an average IC<sub>50</sub> of 30 nM, better than colchicine and the hit compound <b>1f</b> (IC<sub>50</sub> of 65 and 126 nM, respectively). …”