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Genes correlated with SARS-CoV-2 viral load over time are similarly expressed in independent datasets of SARS-CoV-2 infected lung and upper airway cells.
Published 2025“…<p><b>(a)</b> Differential expression patterns for the 112 genes correlated with SARS-CoV-2 viral load across our serial sampling cohort (p<0.001, from <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0317033#pone.0317033.g003" target="_blank">Fig 3A</a>) were examined in two independent RNA-seq datasets of SARS-CoV-2 infection: one of lung cancer cell lines (A549 and Calu-3) infected with SARS-CoV-2 at multiplicity-of-Infection (MOI) of 2 for 24 hours (in biological triplicate)[<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0317033#pone.0317033.ref028" target="_blank">28</a>], and one of nasopharyngeal/oropharyngeal samples in 238 patients with COVID-19, other viral, or non-viral acute respiratory illnesses [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0317033#pone.0317033.ref029" target="_blank">29</a>]. …”
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DnaK’s ATPase activity is stimulated by ribosomes and required to reduce protein synthesis.
Published 2024Subjects: -
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Cytoskeletal Drugs Modulate Off-Target Protein Folding Landscapes Inside Cells
Published 2020“…The decreased compactness and folding stability of PGK could be explained by the decreased extent of crowding induced by these drugs. …”
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Combination of DNA Damage, Autophagy, and ERK Inhibition: Novel Evodiamine-Inspired Multi-Action Pt(IV) Prodrugs with High-Efficiency and Low-Toxicity Antitumor Activity
Published 2023“…Among them, compound <b>10</b> exhibited a 118-fold enhancement in the IC<sub>50</sub> value compared to cisplatin and low toxicity to normal cells. …”
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Combination of DNA Damage, Autophagy, and ERK Inhibition: Novel Evodiamine-Inspired Multi-Action Pt(IV) Prodrugs with High-Efficiency and Low-Toxicity Antitumor Activity
Published 2023“…Among them, compound <b>10</b> exhibited a 118-fold enhancement in the IC<sub>50</sub> value compared to cisplatin and low toxicity to normal cells. …”
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Combination of DNA Damage, Autophagy, and ERK Inhibition: Novel Evodiamine-Inspired Multi-Action Pt(IV) Prodrugs with High-Efficiency and Low-Toxicity Antitumor Activity
Published 2023“…Among them, compound <b>10</b> exhibited a 118-fold enhancement in the IC<sub>50</sub> value compared to cisplatin and low toxicity to normal cells. …”
