Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... حسب Shuai Wang (109515)

"…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …"

Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... حسب Shuai Wang (109515)

"…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …"

Positional cloning of <i>qNN1</i> on chromosome 16. حسب Xinxin Li (281237)

The influence of the controlled pH conditions at the sample preparation step on the obtained signals (panel A: extraction using a mixture of MeOH and EtOH; panel B: extraction usin... حسب Ewa Paszkowska (21246702)

Oxytocin decreases postsynaptic CeA spontaneous GABAergic transmission and blocks presynaptic alcohol effects. حسب Brendan J. Tunstall (6593357)

"…<p>(A, Top) Representative GABA_A-mediated sIPSCs of CeA neurons from nondependent and dependent rats prior to (baseline) and during application of oxytocin (500 nM). …"

Growth Kinetics of Elementary Spiral Steps on Ice Prism Faces Grown in Vapor and Their Temperature Dependence حسب Genki Miyamoto (13914416)

الموضوعات:

The decrease or inhibition of Hsp90 induced REST degradation. حسب Raúl Orozco-Díaz (7067624)

"…<p>(A) Effect of Hsp90α ASO on cell viability. Differentiated SH-SY5Y cells were transfected with different concentrations of Hsp90α ASO. …"

MigC interacts with and decreases the activity of MurD. حسب Jeanette M. Critchlow (21553796)

Values for vertical foot clearance, foot overhang, anteroposterior MoS and mediolateral MoS on steps 4, 5 and 6 across conditions. حسب Timmion K. Skervin (11432568)

الموضوعات:

Expression of lipid biosynthetic genes is decreased with polyamine depletion. حسب Yazmin E. Cruz-Pulido (20285238)

Demonstration of test steps. حسب Jin Zhu (164147)

"…In sand column tests, specimens treated with cementing solution with ferric ion achieved the UCS of 2.83 MPa after five injection cycles, representing a 15-fold increase compared to conventional MICP-treated specimens under the same test conditions. …"

MeV induced RIG-I pathway <i>via</i> RNA polymerase III. حسب Pierre Khalfi (7868252)

الموضوعات:

3D representation of MeV infected cells realized with IMARIS 9.9.1. حسب Pierre Khalfi (7868252)

الموضوعات:

Graphic representation of the SARS-CoV-2 testing outcome of 10,014 nasopharyngeal swabs. حسب William R. Webb (13046882)

Retinoic acid decreases intracellular K⁺ in pectoral fin buds via transcriptional activation of the calcineurin inhibitor <i>rcan2</i>. حسب Xiaowen Jiang (8291814)

Dcp1a protein levels are decreased by KapB expression and Torin treatment. حسب Carolyn-Ann Robinson (13297009)

Propagation of an action potential through ephaptic coupling is achieved for a decreased extracellular conductivity. حسب Karoline Horgmo Jæger (6785450)

Digital Microfluidic Platform Based on Printed Circuit Board for Affinity Evaluation of Mertansine Aptamers حسب Dongliu Xiang (10688647)

الموضوعات:

Training steps of the improved YOLOv4-Tiny. حسب Fuxing He (19555871)

"…Meanwhile, the improved model achieves a processing efficiency of 85 frames/s. In addition, compared with the traditional trajectory prediction model, the constructed model performs the best in table tennis ball trajectory prediction, with errors of 4.5 mm, 25.3 mm, and 35.58 mm. …"

Functional Plasmonic Microscope: Characterizing the Metabolic Activity of Single Cells via Sub-nm Membrane Fluctuations حسب Suraj D. Khochare (18288990)

"…A low-concentration dose showed a reduced fluctuation frequency with consistent fluctuation amplitudes, while the high-concentration dose showcased a decreasing trend in both cases. …"