Synthesis and Biological Evaluation of MEK/mTOR Multifunctional Inhibitors as Novel Anticancer Agents by Marcian E. Van Dort (21374093)

Subjects:

Astrocytes increase contact with vessels and expression of AQP4 following Mtb infection, which is decreased in cytosis⁺ animals. by Amanda S. Latham (12093638)

“…Decreased expression of AQP4, and endfoot contact, is found in cytosis⁺ animals in the frontal cortex (D and E), cerebral nuclei (J and K), brain stem (P and Q), thalamus (V and W) and hippocampus (BB and CC). …”

Survivability is decreased in zebrafish embryos following exogenous treatment with an amino-terminal fragment of nApoE4_1-151. by Madyson M. McCarthy (9238322)

B-factor values of Ca_V3.3 M1425 substitutions. by Yousra El Ghaleb (22075892)

Subjects:

Pairwise correlations of excitatory neurons in APP/PS1 mice are decreased in dCA1, but increased in vCA1. by Udaysankar Chockanathan (18510288)

DICER protein expression is significantly decreased in the absence of MOV10 and FMRP. by Monica C. Lannom (11772729)

TREM1 inhibition decreases HIV mediated inflammatory cytokine production. by Jinhee Hyun (6900683)

cGAS inhibition decreases ISG RNA in H358 cells. by Lorellin A. Durnell-Bettis (22656332)

Metformin lotion decreases TGF-β1 levels in the wounded skin of rats after 10 days of wound healing. by Jianying Zhang (256508)

Proteins in thyroid tissue with differential expression levels above or below 1.5 for all activity groups (0.5, 5, 50 and 500 kBq) (totally 133 proteins). by Malin Larsson (1616557)

Bacterial load in lung and spleen of binge-drinking mice intranasally infected with decreasing doses of <i>B</i>. <i>thailandensis</i>. by Victor M. Jimenez Jr. (8107853)

Data_Sheet_1_Thrombotic Events in COVID-19 Are Associated With a Lower Use of Prophylactic Anticoagulation Before Hospitalization and Followed by Decreases in Platelet Reactivity.d... by Chantal C. Clark (10684632)

Interaction energies of the Ca_V3.3 A398 amino acid substitutions. by Yousra El Ghaleb (22075892)

Subjects:

All Ca_V3.3 variants left-shift the voltage dependence of inactivation. by Yousra El Ghaleb (22075892)

Subjects:

Five exemplary spectrograms showing USV emission (rewarded behavior) followed by the release of a food reward. by Agnieszka D. Wardak (17941139)

Primary endpoint analysis, i.e., time to first occurrence of combined event of 50% decrease in eGFR or ESRD. by Rozita Mohd (7411322)

Trial profile. by Chanel Avenant (409756)

“…We measured testosterone by UHPLC-MS/MS and SHBG by immunoassay in matched pairs of serum samples collected at baseline (D0) and at peak serum progestin levels at 25 weeks post initiation (25W) (n = 214–218 pairs). Both contraceptives substantially decreased, from D0 to 25W, the total testosterone [DMPA-IM D0 0.560, 25W 0.423 nmol/L, -24.3% (p < 0.0001); NET-EN D0 0.551, 25W 0.253 nmol/L, -54.1%, (p < 0.0001)], SHBG [DMPA-IM D0 45.0, 25W 32.7 nmol/L, -29.8% (p < 0.0001); NET-EN D0 50.2, 25W 17.6 nmol/L, -65.1% (p < 0.0001)], and calculated free testosterone levels [DMPA-IM D0 6.87, 25W 5.38 pmol/L, -17.2% (p = 0.0371); NET-EN D0 6.00, 25W 3.70, -40.0% (p < 0.0001)]. …”

Map of average wet-day frequency in terms of fractions [0, 1] (top) and relative linear trend in <i>f</i>_<i>w</i> in terms of %/decade (bottom) for the period 1950–2020... by Rasmus E. Benestad (12530330)

Dopamine turnover, but not total dopamine levels or nigral dopamine neuron numbers, are altered in aged homozygous <i>GBA1</i> D409V KI mice as compared to controls. by Nicole K. Polinski (10947787)

GCase substrate levels are altered in the brain and liver of homozygous <i>GBA1</i> D409V KI mice. by Nicole K. Polinski (10947787)