Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle حسب Jinit, Masania

"…From this and previous transcriptomic studies, signaling involved in enhanced removal of MG-modified protein is likely increased HSPB1-directed HUWE1 ubiquitination through eIF2α-mediated, ATF5-induced increased expression of HSPB1. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle حسب Jinit, Masania

"…From this and previous transcriptomic studies, signaling involved in enhanced removal of MG-modified protein is likely increased HSPB1-directed HUWE1 ubiquitination through eIF2α-mediated, ATF5-induced increased expression of HSPB1. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Quality improvement can decrease blood delivery turnaround time: Evidence from a single tertiary-care academic medical center حسب Hammad Y.A.

"…The transport time significantly decreased from an initial majority of > 15 mins duration, to a majority of < 15 mins transport time after the second audit; there was a 50% improvement in 30 mins response time; and the percentage of requests processed in < 10 mins were significantly higher after the second audit. …"
احصل على النص الكامل

apoA2 correlates to gestational age with decreased apolipoproteins A2, C1, C3 and E in gestational diabetes. حسب Ramanjaneya, Manjunath

"…Apoproteins apoA2, apoC1, apoC3 and apoE are decreased in women with GDM and may have a role in inflammation, as apoA2 and C3 correlated with CRP. …"
احصل على النص الكامل
احصل على النص الكامل

Serum Vitamin D Concentration ≥75 nmol/L Is Related to Decreased Cardiometabolic and Inflammatory Biomarkers, Metabolic Syndrome, and Diabetes; and Increased Cardiorespiratory Fitn... حسب Ganji, Vijay

احصل على النص الكامل
احصل على النص الكامل

In vitro effects of photobiomodulation therapy on 50B11 sensory neurons: evaluation of cell metabolism, oxidative stress, mitochondrial membrane potential (MMP), and capsaicin-indu... حسب Zupin, Luisa

"…Calcium peak stimulated by capsaicin, the ligand of TRPV1 channel, was decreased in neurons pre-irradiated with the combination of the two wavelengths. …"
احصل على النص الكامل
احصل على النص الكامل

A computational approach for investigating the mutational landscape of RAC-alpha serine/threonine-protein kinase (AKT1) and screening inhibitors against the oncogenic E17K mutation... حسب Thirumal Kumar, D

"…The molecular interaction study also revealed that the co-crystallized AKT1 inhibitor N-(4-(5-(3-acetamidophenyl)-2-(2-aminopyridin-3-yl)-3H-imidazo [4,5-b]pyridin-3-yl)benzyl)-3-fluorobenzamide (12j) exhibited a better interaction with native AKT1 compared with the E17K mutant AKT1 protein, whereas, Akti-1/2 exhibited the opposite effects, i.e., a better interaction with the E17K mutant AKT1 than the native AKT1. …"
احصل على النص الكامل
احصل على النص الكامل

Genotoxic impact of long-term cigarette and waterpipe smoking on DNA damage and oxidative stress in healthy subjects حسب Alsaad A.M.

"…This was associated with a marked decrease (50%) in the expression of detoxifying genes (NQO1 and GSTA1) with an increase in CYP1A1 mRNA expression, a cancer-activating gene. …"
احصل على النص الكامل
احصل على النص الكامل

Determining the role of missense mutations in the POU domain of HNF1A that reduce the DNA-binding affinity: A computational approach حسب P., Sneha

"…Maturity-onset diabetes of the young type 3 (MODY3) is a non-ketotic form of diabetes associated with poor insulin secretion. …"
احصل على النص الكامل
احصل على النص الكامل

Biocorrosion behavior of biodegradable nanocomposite fibers coated layer-by-layer on AM50 magnesium implant حسب Abdal-hay, Abdalla

"…The results showed that the AJS 3D membrane fiber layers, particularly the hybrid membrane layers containing a small amount of nHA (3wt.%), induce a higher biocorrosion resistance and effectively decrease the initial degradation rate compared with the neat AM50 coupon samples. …"
احصل على النص الكامل
احصل على النص الكامل

The mitochondrial-related effect of the 905 nm photobiomodulation therapy on 50B11 sensory neurons حسب Zupin, Luisa

"…In this study, a possible molecular mechanism of the 905 nm PBMT (0.25 W/cm2; 3, 6, 12, and 18 J/cm2, 5 Hz) analgesic effect was tested on 50B11 cells, by investigating its impact on mitochondria. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Decreased weight gain and enhanced serum biochemical parameters in rats after vitamin D and Ca supplementation حسب Subih H.

احصل على النص الكامل
احصل على النص الكامل

Metformin attenuates V-domain Ig suppressor of T-cell activation through the aryl hydrocarbon receptor pathway in Melanoma: In Vivo and In Vitro Studies حسب Fawaz E., Alanazi

احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Metformin attenuates V-domain Ig suppressor of T-cell activation through the aryl hydrocarbon receptor pathway in Melanoma: In Vivo and In Vitro Studies حسب Fawaz E., Alanazi

احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Effect of Hyperglycemia on eNOS function in EPCs حسب Elshiekh, Duaa Ibnomer

"…ROS was assessed using CellROX stain following 1 and 3 days of treatment. Results showed that both acute and chronic hyperglycemia showed a trend towards decrease in phosphorylation of eNOS and Akt. …"
احصل على النص الكامل
احصل على النص الكامل

Allergenicity of roasted peanuts treated with a non-human digestive protease حسب Yu, Jianmei

"…Results indicate that alcalase digestion of sonicated peanuts significantly increased protein solubility while decreasing Ara h 1 and Ara h 2 concentrations in both soluble and insoluble portions of peanuts relative to untreated peanuts. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Use and assessment of “e-plastics” as recycled aggregates in cement mortar حسب Makri, Chrysanthi

"…The obtained results, for all RPs, (especially those of 7.5% and 10%) exhibited an increase in the CS of the specimens by 15.4% and 7.8%, respectively, with the MoE decreased in both cases by 18.1% and 23.8%, respectively. …"
احصل على النص الكامل
احصل على النص الكامل

Ecotoxicological Assessment of Thermally- and Hydrogen-Reduced Graphene Oxide/TiO₂ Photocatalytic Nanocomposites Using the Zebrafish Embryo Model. حسب Al-Kandari, Halema

احصل على النص الكامل
احصل على النص الكامل

Methylated pentavalent arsenic metabolites are bifunctional inducers, as they induce cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase through AhR- and Nrf2-dependent mechanis... حسب Anwar-Mohamed, Anwar

احصل على النص الكامل
احصل على النص الكامل

Structural analysis of missense mutations in galactokinase 1 (GALK1) leading to galactosemia type-2. حسب P, Sneha

"…Molecular docking analysis revealed a decrease in interaction between the protein and ATP in all the 3 mutations, and molecular dynamic simulations of 50 ns showed a loss of stability and compactness in the mutant proteins. …"
احصل على النص الكامل
احصل على النص الكامل