First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

“…Representative inhibitor <b>35m</b> exhibits potent HDAC6 inhibitory activity with an IC₅₀ value of 0.019 μM. To our surprise, <b>35m</b> establishes significant improvement in the pharmacokinetic property with much higher AUC_0‑inf (10292 ng·h/mL) and oral bioavailability (93.4%) than hydroximic acid-based HDAC6 inhibitors Tubastatin A and ACY-1215. …”

HE and non-HE applications. by Caitlin E. Burgdorf (17965486)

Virucidal activity of LA, SCFA, and succinic acid combinations associated with an optimal vaginal microbiota or BV, representing a non-optimal vaginal microbiota. by Muriel Aldunate (22411177)

Host population bottlenecks decrease microbiome diversity. by Michael Ørsted (5926028)

Mutations decreasing complexity are more frequent than mutations increasing it. by Pascal F. Hagolani (10189866)

FTY720 decreased viability, proliferation, and motility and induced apoptosis in human hepatoblastoma cells. by Laura L. Stafman (6577184)

“…<p>(A) Following 24 hours of treatment with FTY720, the viability of HuH6 cells measured using the alamarBlue cell viability assay was significantly decreased (LD₅₀ = 8.4 μM, p ≤ 0.05). …”

E₅₀ values. by Junxia Zhou (14381598)

Estimated niche width for 11 native fish species in <i>Arapaima gigas</i> colonized and non-colonized lakes. by Danny Rejas (583637)

Predicting pattern diversity decreases as a function of and . by Selim Haj Ali (21222613)

“…(a) and (b): Average negative predictive value for and , respectively for and . …”

Minimum quorum sensing inhibitory concentrations (MQSICs), minimum inhibitory concentrations (MICs), and concentrations inhibiting 50% of violacein production (IC50s) of compounds... by Jean Paul Dzoyem (6424445)

Subjects:

Frequency of proestrus in non-tumor and tumor-bearing female mice. by Robert Botelho (20308297)

Retinoic acid decreases intracellular K⁺ in pectoral fin buds via transcriptional activation of the calcineurin inhibitor <i>rcan2</i>. by Xiaowen Jiang (8291814)

I348T increases H77 entry dependency on SR-BI, while T385P decreases H77 entry dependency on SR-BI. by Christina Holmboe Olesen (11154333)

Effects of E-cad::EOS overexpression on E-cadherin levels. by Miguel Ramirez Moreno (11034894)

“…The paired-samples Wilcoxon test was used to compare expressing (E-cad, blue in B) and non-expressing areas in same wing discs (C, black in B). …”

Supplementary Figure 3 from Decreased eIF3e Expression Can Mediate Epithelial-to-Mesenchymal Transition through Activation of the TGFβ Signaling Pathway by Guillaume Desnoyers (232704)

The fraction of predicted heterozygotes that are set to “No Call” by RHA decreases as the size of the heterozygote cluster increases. by Orna Mizrahi-Man (42539)

Supplementary Figure 2 from Decreased eIF3e Expression Can Mediate Epithelial-to-Mesenchymal Transition through Activation of the TGFβ Signaling Pathway by Guillaume Desnoyers (232704)

“…<p>Supplementary Figure 2- Phosphorylation of eIF4E is decreased in A549 and MCF-10A cells that have decreased eIF3e expression. …”

EQI decreases malonyl-CoA levels in <i>S</i>. <i>aureus</i>. by Erica C. Larson (1344687)

Test characteristics for identifying stenosis ≥ 50% in any limb from aorta till popliteal artery in the overall population (<i>n = 126 limbs</i>). by O. Stivalet (6890189)

Homologues of the <i>A</i>. <i>thaliana</i> gene AT3G59280 identified by BlastP search (E value < 1E-5). by Chloe Casey (14341756)