RNS60 treatment of tMCAo mice decreased microglial activation in the CA3 region of the ipsilateral hippocampus. حسب Gloria Patricia Baena-Caldas (17721328)

H2-K^b overexpression decreases NSPC proliferation and impairs adult hippocampal neurogenesis. حسب Karin Lin (11037548)

Synthesis and Antiproliferative Activity of a New Series of Mono- and Bis(dimethylpyrazolyl)‑<i>s</i>‑triazine Derivatives Targeting EGFR/PI3K/AKT/mTOR Signaling Cascades حسب Ihab Shawish (13015516)

"…The antiproliferative activity of the novel <i>mono</i>- and <i>bis</i>(dimethylpyrazolyl)-<i>s</i>-triazine derivatives was studied against three cancer cell lines, namely, MCF-7, HCT-116, and HepG2. <i>N</i>-(4-Bromophenyl)-4-(3,5-dimethyl-1<i>H</i>-pyrazol-1-yl)-6-morpholino-1,3,5-triazin-2-amine <b>4f</b>, <i>N</i>-(4-chlorophenyl)-4,6-bis­(3,5-dimethyl-1<i>H</i>-pyrazol-1-yl)-1,3,5-triazin-2-amine <b>5c</b>, and 4,6-<i>bis</i>(3,5-dimethyl-1<i>H</i>-pyrazol-1-yl)-<i>N</i>-(4-methoxyphenyl)-1,3,5-triazin-2-amine <b>5d</b> showed promising activity against these cancer cells: <b>4f</b> [(IC₅₀ = 4.53 ± 0.30 μM (MCF-7); 0.50 ± 0.080 μM (HCT-116); and 3.01 ± 0.49 μM (HepG2)]; <b>5d</b> [(IC₅₀ = 3.66 ± 0.96 μM (HCT-116); and 5.42 ± 0.82 μM (HepG2)]; and <b>5c</b> [(IC₅₀ = 2.29 ± 0.92 μM (MCF-7)]. …"

Synthesis and Antiproliferative Activity of a New Series of Mono- and Bis(dimethylpyrazolyl)‑<i>s</i>‑triazine Derivatives Targeting EGFR/PI3K/AKT/mTOR Signaling Cascades حسب Ihab Shawish (13015516)

"…The antiproliferative activity of the novel <i>mono</i>- and <i>bis</i>(dimethylpyrazolyl)-<i>s</i>-triazine derivatives was studied against three cancer cell lines, namely, MCF-7, HCT-116, and HepG2. <i>N</i>-(4-Bromophenyl)-4-(3,5-dimethyl-1<i>H</i>-pyrazol-1-yl)-6-morpholino-1,3,5-triazin-2-amine <b>4f</b>, <i>N</i>-(4-chlorophenyl)-4,6-bis­(3,5-dimethyl-1<i>H</i>-pyrazol-1-yl)-1,3,5-triazin-2-amine <b>5c</b>, and 4,6-<i>bis</i>(3,5-dimethyl-1<i>H</i>-pyrazol-1-yl)-<i>N</i>-(4-methoxyphenyl)-1,3,5-triazin-2-amine <b>5d</b> showed promising activity against these cancer cells: <b>4f</b> [(IC₅₀ = 4.53 ± 0.30 μM (MCF-7); 0.50 ± 0.080 μM (HCT-116); and 3.01 ± 0.49 μM (HepG2)]; <b>5d</b> [(IC₅₀ = 3.66 ± 0.96 μM (HCT-116); and 5.42 ± 0.82 μM (HepG2)]; and <b>5c</b> [(IC₅₀ = 2.29 ± 0.92 μM (MCF-7)]. …"

Corn gluten meal induces enteritis and decreases intestinal immunity and antioxidant capacity in turbot (<i>Scophthalmus maximus</i>) at high supplementation levels - Fig 2 حسب Nan Bai (1576645)

"…</b> (a–d) Representative images of decreased height and increased fusion of the mucosal folds with increasing corn gluten meal level (bar = 500 <b>μ</b>m). …"

Multiple trauma and hemorrhagic shock induce a transcriptional immune response. حسب Marc-Alexander Oestreich (13961375)

Fold changes for all differentially expressed genes. حسب June Guha (14041154)

Mechanistic Insight of Synthesized 1,4-Dihydropyridines as an Antidiabetic Sword against Reactive Oxygen Species حسب Peter A. Sidhom (14313061)

"…Also, compound <b>8b</b> decreased blood glucose by α-glucosidase inhibition (IC₅₀ = 4.48 ± 0.32 μM), compared to acarbose (7.40 ± 0.41 μM), based selectively on the plasma window of <b>8b</b>. …"

The decrease in blood flow disrupts CV pruning. حسب Lin Wen (557398)

<i>S</i>. Typhimurium coordinates protein synthesis with protein folding capacity. حسب Carissa Chan (18310140)

الموضوعات:

Fig 2 - حسب Henning Carstens (13132801)

Sequence of <i>DpAP2</i> promoter. حسب Lingru Ruan (18995544)

"…Carotenoid biosynthesis was enhanced by <i>DpAP2</i> overexpression (1.4930 fold of control) and exogenous substances such as GA3 (1.5889 fold of control), which laid a foundation for massive accumulation of carotenoids in microalgae. …"

NS attenuates ox-LDL-induced foam cell formation. حسب Yihua Wang (491766)

The GluN2B-C456Y mutation decreases recombinant NMDAR currents and alters receptor properties. حسب Wangyong Shin (6793040)

"…<p>(A) The GluN2B-C456Y mutation strongly decreases diheteromeric GluN1/GluN2B NMDAR currents in <i>Xenopus</i> oocytes. …"

Geniposide(Gen) significantly decreased the levels of TNF-α and MIP-1α in BALF of bleomycin-induced PF mice. حسب Jian-Bin Yin (19556105)

Decreased clonogenic capacity of U87MG and U251MG glioma cells dependent on SHG-44 concentration. حسب Denis Mustafov (19137870)

"…<b>(B)</b> A significant decrease in the proliferative clonal capacity of U251MG colonies was observed with 50ΜM and 100ΜM SHG-44 treatment. …"

Decreased phosphorylation of EIF2α underlies the impairment of arsenite-induced SG formation in LSM12-depleted cells. حسب Jongbo Lee (9914603)

"…<p>(A) LSM12 depletion does not suppress the SG assembly under sorbitol-induced osmotic stress. …"

Dominant positive effect of mutated versions of <i>PTR1</i>. حسب Sophia Bigot (16469992)

الموضوعات:

<i>L</i>. <i>major</i> Friedlin <i>FT1</i> single knockout. حسب Sophia Bigot (16469992)

الموضوعات:

Image_1_Desmoglein-4 Deficiency Exacerbates Psoriasiform Dermatitis in Rats While Psoriasis Patients Displayed a Decreased Gene Expression of DSG4.TIF حسب Tamara Moreno-Sosa (10717320)