First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

“…Representative inhibitor <b>35m</b> exhibits potent HDAC6 inhibitory activity with an IC₅₀ value of 0.019 μM. To our surprise, <b>35m</b> establishes significant improvement in the pharmacokinetic property with much higher AUC_0‑inf (10292 ng·h/mL) and oral bioavailability (93.4%) than hydroximic acid-based HDAC6 inhibitors Tubastatin A and ACY-1215. …”

First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

“…Representative inhibitor <b>35m</b> exhibits potent HDAC6 inhibitory activity with an IC₅₀ value of 0.019 μM. To our surprise, <b>35m</b> establishes significant improvement in the pharmacokinetic property with much higher AUC_0‑inf (10292 ng·h/mL) and oral bioavailability (93.4%) than hydroximic acid-based HDAC6 inhibitors Tubastatin A and ACY-1215. …”

Decreased echinocandin susceptibility in <i>Candida parapsilosis</i> causing candidemia and emergence of a pan-echinocandin resistant case in China by Yating Ning (11264310)

Excision of HIF1α decreases viral reactivation from latency in infected splenocytes in vivo. by Darlah M. López-Rodríguez (8098544)

ROC curve and P-R curve (attack traffic proportion = 50%). by Longyan Ran (18452261)

TBEV-induced translational arrest results in the decreased protein levels of GAPDH, HPRT1, and viperin. by Martin Selinger (3195987)

Drive dynamics for split^<50cM <i>ClvR</i>s with different genetic linkage and migration rates. by Georg Oberhofer (3401438)

ngLVA degradation kinetics. by Nicole A. Grieshaber (11175417)

“…Chloramphenicol treated sample showed a decrease of half max intensity 30 mins after treatment.…”

Position relative deviation values for every experimental set-up, detector and source combination plotted against the respective SNR values. by Antanas Bukartas (10023785)

Negative correlations between allele frequency decrease in HiP and male-deleterious association strength. by Pim van Hooft (272911)

Activity relative deviation values for every experimental set-up, detector and source combination plotted against the respective SNR values. by Antanas Bukartas (10023785)

Lateral position relative deviation values for every experimental set-up, detector and source combination plotted against the respective SNR values. by Antanas Bukartas (10023785)

Longitudinal position relative deviation values for every experimental set-up, detector and source combination plotted against the respective SNR values. by Antanas Bukartas (10023785)

Visualisation of relative alignment of the count-rate function and the acquisition time intervals. by Antanas Bukartas (10023785)

Intercoordinate distance analysis of the GNSS coordinates recorded and processed by the Nugget software for experimental set-up 1. by Antanas Bukartas (10023785)

Distances from the roadside to the ¹³⁷Cs and ⁶⁰Co sources and activities of the sources used in the experiment for every experimental set-up. by Antanas Bukartas (10023785)

Comparison of the asymptotic values of quantile regression for activity and position relative deviations obtained using theoretical data (from [13]) and experimental data. by Antanas Bukartas (10023785)

Prevalence and anatomic level of stenosis ≥ 50% in either limb. by O. Stivalet (6890189)

E₅₀ values of angle. by Junxia Zhou (14381598)

Curve fitting of E₅₀. by Junxia Zhou (14381598)