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Synaptopathy at IHC-SGN synapses decreases the peak of the CAP significantly, without changes to peak latency and width.
Published 2021“…<p>(A) Sound-evoked CAPs of SGN fiber populations with different synaptopathy scenarios at 70dB SPL, averaged over 50 simulations. …”
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Elevated IDO activity in HD mouse brains is decreased by <i>ex-vivo</i> iron chelation.
Published 2021“…<p>Mouse pups were supplemented with carbonyl iron from postnatal days 10–17 and then were sacrificed at 14 weeks of age. <b>A.</b> Striatal IDO activity is increased in N171-82Q HD mice and significantly decreased by <i>ex vivo</i> iron (III) chelation (50 μM deferoxamine). …”
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