Showing 1 - 20 results of 65,862 for search '(((( 50 ((mean decrease) OR (nn decrease)) ) OR ( 5 a decrease ))) OR ( 5 sizes decrease ))', query time: 0.87s Refine Results
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    Attenuation of spheroid size decrease or MUC5AC increase by hit compounds. by Pranjali Beri (14945400)

    Published 2023
    “…<p>Final hit compounds (with hit concentration and corresponding target) that <b>A)</b> increased bronchosphere size compared to DMSO + 3% CSE control bronchospheres or <b>B)</b> decreased secreted MUC5AC. …”
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    Primary small molecule screen to identify attenuators of CSE-induced decrease in size and increase in MUC5AC. by Pranjali Beri (14945400)

    Published 2023
    “…Hit compounds at 1 and 10μM concentrations that <b>B)</b> increased spheroid size (swell) or <b>C)</b> decreased MUC5AC staining in the lumen relative to DMSO and CSE 3%-treated bronchospheres. …”
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    Alternative bounded and monotonically decreasing functions do not accurately fit the bias in the naïve SI. by Liron Sheintuch (12078310)

    Published 2022
    “…<p>(A-D) Fitting the naïve SI (blue) of simulated data using different types of bounded and monotonically decreasing functions with three free parameters. …”
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    Validation of primary screen hits reveals compounds that recapitulate increased spheroid size (swell) or decreased MUC5AC in the lumen. by Pranjali Beri (14945400)

    Published 2023
    “…Compounds that appeared to cause toxicity were identified by observing a significant decrease in spheroid counts in the swell readout or a significant decrease in the total nuclear intensity of the MUC5AC ratio readout. …”
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