Showing 141 - 160 results of 9,068 for search '(((( 50 ((ng decrease) OR (we decrease)) ) OR ( 5 ng decrease ))) OR ( 50 mg decrease ))', query time: 0.46s Refine Results
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    Design and Synthesis of Novel Spiro Derivatives as Potent and Reversible Monoacylglycerol Lipase (MAGL) Inhibitors: Bioisosteric Transformation from 3‑Oxo-3,4-dihydro‑2<i>H</i>‑ben... by Shuhei Ikeda (2380180)

    Published 2021
    “…Optimization of the left hand side afforded <b>4f</b> as a promising reversible MAGL inhibitor, which showed potent in vitro MAGL inhibitory activity (IC<sub>50</sub> 6.2 nM), good oral absorption, blood–brain barrier penetration, and significant pharmacodynamic changes (2-arachidonoylglycerol increase and arachidonic acid decrease) at 0.3–10 mg/kg, po. in mice.…”
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    Inhibition of pan- and HDAC isoform activities. by Mira Jung (1277502)

    Published 2024
    “…Cellular growth inhibition studies show that SP-1-303 differentially inhibits growth of estrogen receptor positive breast cancer (ER+ BC) cells with effective growth inhibition concentrations (EC<sub>50</sub>) for MCF-7 and T47D cells ranging from 0.32 to 0.34 μM, compared to 1.2–2.5 μM for triple negative breast cancer cells, and ~12 μM for normal breast epithelial cells. …”
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    XRD diffraction pattern spectra of PFAgNPs. by Kenedy Kiyimba (9942393)

    Published 2025
    “…The no observed adverse effect level was 50mg/kgBW, the lowest observed adverse effect level was 100 mg/kgBW, and median lethal dose (LD<sub>50</sub>) was 1000 mg/kg. …”