بدائل البحث:
ngn decrease » mean decrease (توسيع البحث), _ decrease (توسيع البحث), a decrease (توسيع البحث)
nn decrease » _ decrease (توسيع البحث), a decrease (توسيع البحث), mean decrease (توسيع البحث)
nm decrease » _ decrease (توسيع البحث), a decrease (توسيع البحث), we decrease (توسيع البحث)
n decrease » _ decrease (توسيع البحث), a decrease (توسيع البحث), _ decreased (توسيع البحث)
5 nm » 5 mm (توسيع البحث), 5 cm (توسيع البحث)
50 n » 50 ns (توسيع البحث), 50 ng (توسيع البحث), 50 μ (توسيع البحث)
ngn decrease » mean decrease (توسيع البحث), _ decrease (توسيع البحث), a decrease (توسيع البحث)
nn decrease » _ decrease (توسيع البحث), a decrease (توسيع البحث), mean decrease (توسيع البحث)
nm decrease » _ decrease (توسيع البحث), a decrease (توسيع البحث), we decrease (توسيع البحث)
n decrease » _ decrease (توسيع البحث), a decrease (توسيع البحث), _ decreased (توسيع البحث)
5 nm » 5 mm (توسيع البحث), 5 cm (توسيع البحث)
50 n » 50 ns (توسيع البحث), 50 ng (توسيع البحث), 50 μ (توسيع البحث)
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Discovery of Novel Pyrimidine-Based Capsid Assembly Modulators as Potent Anti-HBV Agents
منشور في 2021"…One of the synthesized derivatives, compound <b>23h</b> (R<sup>1</sup> = MeSO<sub>2</sub>, R<sup>2</sup> = 1-piperidin-4-amine, R<sup>3</sup> = 3-Cl-4-F-aniline) displayed potent inhibitory effects in the in vitro assays (52% inhibition in the protein-based assay at 100 nM and an IC<sub>50</sub> value of 181 nM in the serum HBV DNA quantification assay). …"
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Fluorescent intensity at 520 nm (RNase A/B) and 556 nm (DNase I) versus time for nucleases in DI water lysed with Lyse-It at 30% and 50% power for varying time.
منشور في 2019"…<b>(A)</b> 20 pM RNase A <b>(B)</b> 46 pM RNase B, <b>(C)</b> 10.5 nM DNase I. As microwave power and time increase, nuclease activity decreases.…"
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Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance...
منشور في 2021"…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo[1,5-<i>a</i>]pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC<sub>50</sub> = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …"
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Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance...
منشور في 2021"…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo[1,5-<i>a</i>]pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC<sub>50</sub> = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …"
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