Discovery of Triazolyl Derivatives of Cucurbitacin B Targeting IGF2BP1 against Non-Small Cell Lung Cancer by Fan-Fan Shang (16953264)

“…Derivative <b>A11</b> directly binds to the insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) protein with a <i>K</i>_D value of 2.88 nM, which is about 23-fold more potent than CuB, leading to the decreased expression of downstream apoptosis- and cell cycle-related proteins. …”

2‑Aminobenzoxazole Derivatives as Potent Inhibitors of the Sphingosine-1-Phosphate Transporter Spinster Homolog 2 (Spns2) by Ariel L. Burgio (15069256)

“…Our studies revealed <b>SLB1122168</b> (<b>33p</b>), which is a potent inhibitor (IC₅₀ = 94 ± 6 nM) of Spns2-mediated S1P release. …”

Design and Synthesis of Novel Spiro Derivatives as Potent and Reversible Monoacylglycerol Lipase (MAGL) Inhibitors: Bioisosteric Transformation from 3‑Oxo-3,4-dihydro‑2<i>H</i>‑ben... by Shuhei Ikeda (2380180)

“…Optimization of the left hand side afforded <b>4f</b> as a promising reversible MAGL inhibitor, which showed potent in vitro MAGL inhibitory activity (IC₅₀ 6.2 nM), good oral absorption, blood–brain barrier penetration, and significant pharmacodynamic changes (2-arachidonoylglycerol increase and arachidonic acid decrease) at 0.3–10 mg/kg, po. in mice.…”

E₅₀ values. by Junxia Zhou (14381598)

Tube formation: Representative light microscopic images of the structures formed by HPAEC and CTEPH-EC seeded and incubated for 5h30 min in the absence or presence of 50 uM VER-155... by William Salibe-Filho (9727738)

Top 50 up-regulated genes in <i>lin-15B(n744</i>), mutant in starved L1 animals. by Ashwin Seetharaman (615458)

Modeling methods of included studies (n = 61). by Natalie Riva Smith (13899600)

DataSheet_1_Circulating exosomes decrease in size and increase in number between birth and age 7: relations to fetal growth and liver fat.pdf by Marta Díaz (337207)

Flow chart of the study participants including changes in exercise capacity (n = 198). by Feras Haskiah (14204097)

Supplementary Material for: Cardiac Troponin Is Elevated in Patients with Thyrotoxicosis and Decreases as Thyroid Function Improves and Brain Natriuretic Peptide Levels Decrease by Watanabe N. (4118812)

Retinoic acid decreases intracellular K⁺ in pectoral fin buds via transcriptional activation of the calcineurin inhibitor <i>rcan2</i>. by Xiaowen Jiang (8291814)

Description of the cohort (N = 118 patients). by Bastien Le Floc’h (14773916)

“…An HLA-G plasma level ≤ 50 ng/ml on day 8 after LT was significantly associated with a higher rejection risk. …”

The fraction of predicted heterozygotes that are set to “No Call” by RHA decreases as the size of the heterozygote cluster increases. by Orna Mizrahi-Man (42539)

NatB inactivation decreased the level of MAPK and proposed model of EGFR/MAPK signaling regulation by NatB and the N-end rule pathways. by Zhentao Sheng (107495)

Exercise capacity at baseline, pre-lockdown, and post lock down measurements (n = 198). by Feras Haskiah (14204097)

Event-free survival estimate of the pulmonary arterial hypertension cohort based on the HRR1 <18 beats (n = 50) and ≥18 beats (n = 52) after a long follow-up period. by Camila Farnese Rezende (12666902)

Populations and outcomes modeled in included studies (n = 61). by Natalie Riva Smith (13899600)

Prevalence of smoking during COVID19 (n = 1844). by Mahmoud A. Alomari (14780446)

Sexual symptoms, (N = 73). by Wafa Y. Ahmed (20727327)

Purpose of deinfibulation, (N = 73). by Wafa Y. Ahmed (20727327)