Showing 161 - 180 results of 34,175 for search '(((( 50 ((nn decrease) OR (a decrease)) ) OR ( a non decrease ))) OR ( 50 ms decrease ))', query time: 0.73s Refine Results
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    20E repressed ILP-mediated cell membrane translocation of HaP60 and HaP110, dephosphorylated HaP60 and HaP110, and decreased their interaction. by Yu-Qin Di (8752317)

    Published 2021
    “…Green, HaP60 or HaP110; red, cell membrane stained with WGA; blue, nuclei stained with DAPI; merge, overlapped green, blue, and red fluorescence. Bar, 50 μm. <b>C.</b> Co-IP assay showed that 20E decreased the HaP60–HaP110 interaction and induced dephosphorylation in cells. …”
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    Data_Sheet_1_rdHSV-CA8 non-opioid analgesic gene therapy decreases somatosensory neuronal excitability by activating Kv7 voltage-gated potassium channels.docx by Munal B. Kandel (18526539)

    Published 2024
    “…These data demonstrate for the first time that vHCA8 produces Kv7 channel activation, which decreases neuronal excitability in nociceptors. This suppression of excitability may translate in vivo as non-opioid dependent behavioral- or clinical analgesia, if proven behaviorally and clinically.…”
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    Inhibiting Gamma-secretase activity without interfering in Notch signaling: Decreasing the inflammatory response in patients with cutaneous leishmaniasis by Lucas Carvalho (3093042)

    Published 2020
    “….; *P<0.05, **P<0.01, ***P<0.001 and ****P<0.0001.</p><p><b>Figure 3 - Non-selective gamma-secretase inhibitor (DAPT) decreases inflammatory-associated proteins production from CL patients in response to <i>Leishmania</i>antigens.…”
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    Image 9_Behavioral and biochemical changes associated with the analgesic effects of (2R,6R)-hydroxynorketamine alone and in combination with meloxicam following disk puncture in mi... by Vaskar Das (21529538)

    Published 2025
    “…EC<sub>50</sub> estimates for (2R,6R)-Hydroxynorketamine were 14.2 mg/kg (95% CI: 10.3 mg/kg to 19.7 mg/kg) in male and 16.9 mg/kg (95% CI: 12.8 mg/kg to 22.3 mg/kg) in female mice (P < 0.637). (2R,6R)-Hydroxynorketamine plus meloxicam enhanced the analgesic effect on the AUC<sub>0−3d</sub> of meloxicam alone. (2R,6R)-Hydroxynorketamine analgesia was associated with increases in Glutamate receptor A1 & A2, p-Kv2.1, p-CaMKII and reduced BDNF protein ratios in the hippocampus, attenuated c-Fos in the spinal cord, and decreased BDNF at the dorsal root ganglion (DRG).…”
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    Image 8_Behavioral and biochemical changes associated with the analgesic effects of (2R,6R)-hydroxynorketamine alone and in combination with meloxicam following disk puncture in mi... by Vaskar Das (21529538)

    Published 2025
    “…EC<sub>50</sub> estimates for (2R,6R)-Hydroxynorketamine were 14.2 mg/kg (95% CI: 10.3 mg/kg to 19.7 mg/kg) in male and 16.9 mg/kg (95% CI: 12.8 mg/kg to 22.3 mg/kg) in female mice (P < 0.637). (2R,6R)-Hydroxynorketamine plus meloxicam enhanced the analgesic effect on the AUC<sub>0−3d</sub> of meloxicam alone. (2R,6R)-Hydroxynorketamine analgesia was associated with increases in Glutamate receptor A1 & A2, p-Kv2.1, p-CaMKII and reduced BDNF protein ratios in the hippocampus, attenuated c-Fos in the spinal cord, and decreased BDNF at the dorsal root ganglion (DRG).…”