Pharmacological Mechanism of the Non-hallucinogenic 5‑HT_2A Agonist Ariadne and Analogs حسب Michael J. Cunningham (14267038)

"…Compared to DOM, Ariadne shows lower signaling potency and efficacy in multiple signaling pathways examined (G_q, G₁₁, and β-arrestin2) coupled to 5-HT_2A receptors. We confirmed the shift in signaling for an α-propyl analog and provide a molecular docking rationale for the progressive decrease in signaling potency with the growing length of the α-substituent. …"

Pharmacological Mechanism of the Non-hallucinogenic 5‑HT_2A Agonist Ariadne and Analogs حسب Michael J. Cunningham (14267038)

"…Compared to DOM, Ariadne shows lower signaling potency and efficacy in multiple signaling pathways examined (G_q, G₁₁, and β-arrestin2) coupled to 5-HT_2A receptors. We confirmed the shift in signaling for an α-propyl analog and provide a molecular docking rationale for the progressive decrease in signaling potency with the growing length of the α-substituent. …"

Inhibiting translation in 5-HT neurons does not recapitulate a <i>Minute</i> phenotype. حسب Lisa Patricia Deliu (13570709)

Effects of FCCP and verapamil on MMP of T47D and HT29 cancer cells. حسب Jin Won Park (2901029)

The effect of Mdivi-1 administration on cell apoptosis in vivo. حسب Dong Ma (584680)

Effect of 5-HTR blockade on the relationship between error rate and reaction time in the reward-size task. حسب Yukiko Hori (299784)

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Human cerebral organoids treated with VPA show a decreased size, impaired neurogenesis, and induction of senescence in NE cells. حسب Muriel Rhinn (406515)

Deep crypt secretory (DCS) cells are predominantly distributed in the proximal colon, with a progressive decrease towards the distal colon. حسب Daisuke Sugahara (2047696)

Decrease of the DXR-induced genotoxicity and nongenotoxic effects of Theobroma cacao revealed by micronucleus assay حسب M. F. G. Boriollo (4894975)

EGFR/ERK signaling activity decreases throughout LEC elimination with endocytic activity dependency. حسب Kevin Yuswan (19845885)

Exposure to low CO₂ levels decreases ER cholesterol levels. حسب Nityanand Bolshette (17396845)

"…<b>(C)</b> Total cholesterol quantification (with fluorometric assay kit) in NIH3T3 cells depleted with sterols for 2 h or exposed to different CO₂ levels for 4 h (mean ± SE, <i>n</i> = 3 biological replicates per condition, **<i>P</i> < 0.01, nonsignificant (ns), two-sided Student’s <i>t</i> test). <b>(D, E)</b> The free cholesterol and cholesterol ester levels in the ER membrane from the cells as in <b>(C)</b>, were quantified with shotgun lipidomics analysis (see <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002367#pbio.3002367.s007" target="_blank">S7 Fig</a> and <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002367#pbio.3002367.s012" target="_blank">S5 Table</a>) (mean ± SE, <i>n</i> = 3 independent experiments, **<i>P</i> < 0.01, *<i>P</i> < 0.05, nonsignificant (ns) two-sided Student’s <i>t</i> test). …"

HT1080 human sarcoma xenograft growth in CD-1 athymic mice and body weight comparison under therapy with intravenous (i.v.) tTF-NGR, tumor radiotherapy, and a combination of both t... حسب Caroline Brand (3448523)

"…<p>(A) Arrows show treatment intervention for tTF-NGR (1.5 mg/kg body weight (bw) x 5) or tumor radiotherapy (4.8 Gy x 2). …"

Treatment with TDF decreased cell viability and induced morphological changes in hepatic stellate cells. حسب Sung Won Lee (222509)

Conditional ablation of <i>Ybx1</i> leads to a reduction in cortical progenitor cell pool and a decrease in cortical thickness. حسب Jian Zhang (1682)

Expression of 5HT-2AR, 2BR, 3AR, and 3BR mRNA in the mid colon. حسب Ji Eun Kim (403026)

SWSs measured for cell-laden gels with 5 mg/ml Matrigel and 1 mg/ml (M5C1), 2 mg/ml (M5C2), and 3 mg/ml (M5C3) collagen type I. حسب Shao-Lun Lu (12360135)

Table_1_Sub-Acute Treatment of Curcumin Derivative J147 Ameliorates Depression-Like Behavior Through 5-HT1A-Mediated cAMP Signaling.DOCX حسب Jianxin Li (158332)

"…Background<p>Major depressive disorder (MDD) is a severe mental disorder related to the deficiency of monoamine neurotransmitters, particularly to abnormalities of 5-HT (5-hydroxytryptamine, serotonin) and its receptors. …"

Thermal denaturation of ZIKV NS2B/NS3^pro and CHIKV nsP2^pro using fluorescence spectroscopy. حسب Raphael J. Eberle (9286932)

Inducing proteotoxic stress in 5-HT neurons does not recapitulate a <i>Minute</i> phenotype. حسب Lisa Patricia Deliu (13570709)

S5 File - حسب Wenxin Ye (14392899)