بدائل البحث:
ns decrease » nn decrease (توسيع البحث), _ decrease (توسيع البحث), we decrease (توسيع البحث)
nm decrease » nn decrease (توسيع البحث), _ decrease (توسيع البحث), we decrease (توسيع البحث)
ht decrease » _ decrease (توسيع البحث), nn decrease (توسيع البحث), we decrease (توسيع البحث)
a decrease » _ decrease (توسيع البحث), _ decreased (توسيع البحث), _ decreases (توسيع البحث)
5 nm » 5 mm (توسيع البحث), 5 cm (توسيع البحث)
5 ht » 5 h (توسيع البحث)
ns decrease » nn decrease (توسيع البحث), _ decrease (توسيع البحث), we decrease (توسيع البحث)
nm decrease » nn decrease (توسيع البحث), _ decrease (توسيع البحث), we decrease (توسيع البحث)
ht decrease » _ decrease (توسيع البحث), nn decrease (توسيع البحث), we decrease (توسيع البحث)
a decrease » _ decrease (توسيع البحث), _ decreased (توسيع البحث), _ decreases (توسيع البحث)
5 nm » 5 mm (توسيع البحث), 5 cm (توسيع البحث)
5 ht » 5 h (توسيع البحث)
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Pharmacological Mechanism of the Non-hallucinogenic 5‑HT<sub>2A</sub> Agonist Ariadne and Analogs
منشور في 2022"…Compared to DOM, Ariadne shows lower signaling potency and efficacy in multiple signaling pathways examined (G<sub>q</sub>, G<sub>11</sub>, and β-arrestin2) coupled to 5-HT<sub>2A</sub> receptors. We confirmed the shift in signaling for an α-propyl analog and provide a molecular docking rationale for the progressive decrease in signaling potency with the growing length of the α-substituent. …"
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88
Pharmacological Mechanism of the Non-hallucinogenic 5‑HT<sub>2A</sub> Agonist Ariadne and Analogs
منشور في 2022"…Compared to DOM, Ariadne shows lower signaling potency and efficacy in multiple signaling pathways examined (G<sub>q</sub>, G<sub>11</sub>, and β-arrestin2) coupled to 5-HT<sub>2A</sub> receptors. We confirmed the shift in signaling for an α-propyl analog and provide a molecular docking rationale for the progressive decrease in signaling potency with the growing length of the α-substituent. …"
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Exposure to low CO<sub>2</sub> levels decreases ER cholesterol levels.
منشور في 2023"…<b>(C)</b> Total cholesterol quantification (with fluorometric assay kit) in NIH3T3 cells depleted with sterols for 2 h or exposed to different CO<sub>2</sub> levels for 4 h (mean ± SE, <i>n</i> = 3 biological replicates per condition, **<i>P</i> < 0.01, nonsignificant (ns), two-sided Student’s <i>t</i> test). <b>(D, E)</b> The free cholesterol and cholesterol ester levels in the ER membrane from the cells as in <b>(C)</b>, were quantified with shotgun lipidomics analysis (see <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002367#pbio.3002367.s007" target="_blank">S7 Fig</a> and <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002367#pbio.3002367.s012" target="_blank">S5 Table</a>) (mean ± SE, <i>n</i> = 3 independent experiments, **<i>P</i> < 0.01, *<i>P</i> < 0.05, nonsignificant (ns) two-sided Student’s <i>t</i> test). …"