يعرض 161 - 180 نتائج من 68,686 نتيجة بحث عن '(((( 50 ((we decrease) OR (mean decrease)) ) OR ( 5 a decrease ))) OR ( 50 ms decrease ))', وقت الاستعلام: 0.94s تنقيح النتائج
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    Downregulation of TRIM37 expression exacerbates pathological damage in the MS model. حسب Lai Jiang (2401513)

    منشور في 2025
    "…<b>(f, g)</b> TUNEL staining (n = 3) demonstrated a significant increase in the apoptosis rate in the model group compared to the control group. Scale bar = 50 μm. (h) qRT-PCR (n = 6) and <b>(i, j)</b> Western blot (n = 3) both showed a significant decrease in the <i>TRIM37</i> mRNA and protein levels in the LPC-induced MS model compared to the control group. * <i><i>P</i></i> < 0.05, ** <i><i>P</i></i> < 0.01, *** <i><i>P</i></i> < 0.001, **** <i><i>P</i></i> < 0.0001, ns = not significant.…"
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    Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... حسب Shuai Wang (109515)

    منشور في 2021
    "…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC<sub>50</sub> = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …"
  17. 177

    Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... حسب Shuai Wang (109515)

    منشور في 2021
    "…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC<sub>50</sub> = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …"
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