Synthesis and Biological Evaluation of Peripheral 5HT_2B Antagonists for Liver Fibrosis by Jihyeon Yoon (8705706)

“…Recent studies have shown that antagonizing 5-hydroxytryptamine receptor 2B (5HT_2B) stimulates the apoptosis of activated hepatic stellate cells and inhibits their proliferation while concurrently regressing hepatocyte proliferation. …”

5-HT- induced mitochondrial ROS inhibits <i>P</i>. <i>berghei</i> infection. by Li Gao (131516)

Effect of 5-HTR blockade on reaction time in the work/delay task. by Yukiko Hori (299784)

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Effect of 5-HTR blockade on error pattern in the reward-size task. by Yukiko Hori (299784)

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Effect of 5-HTR blockade on error pattern in the work/delay task. by Yukiko Hori (299784)

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Effect of 5-HTR blockade on reaction time in the reward-size task. by Yukiko Hori (299784)

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Effect of 5-HTR blockade on reaction time in the work/delay task. by Yukiko Hori (299784)

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Effects of H5 (20 and 40 mg/kg, p.o.), and diazepam (2.5 mg/kg, i.p.) in the Rota-rod test in mice. by Maria Alice Miranda Bezerra Medeiros (11752002)

Design, Synthesis, and Biological Evaluation of [1,2,5]Oxadiazolo[3,4‑<i>b</i>]pyridin-7-ol as Mitochondrial Uncouplers for the Treatment of Obesity and Metabolic Dysfunction-Assoc... by Mary A. Foutz (20361830)

“…In a Gubra-Amylin (GAN) mouse model of MASH, <b>SHO1122147</b> was efficacious in decreasing body weight and liver triglyceride levels at 200 mg kg^–1 day^–1 without changes in body temperature. …”

Cell proliferation was decreased more by combination treatment of SLCP and BBR than individual treatments. by Panchanan Maiti (1459852)

Pharmacological Mechanism of the Non-hallucinogenic 5‑HT_2A Agonist Ariadne and Analogs by Michael J. Cunningham (14267038)

“…Compared to DOM, Ariadne shows lower signaling potency and efficacy in multiple signaling pathways examined (G_q, G₁₁, and β-arrestin2) coupled to 5-HT_2A receptors. We confirmed the shift in signaling for an α-propyl analog and provide a molecular docking rationale for the progressive decrease in signaling potency with the growing length of the α-substituent. …”

Pharmacological Mechanism of the Non-hallucinogenic 5‑HT_2A Agonist Ariadne and Analogs by Michael J. Cunningham (14267038)

“…Compared to DOM, Ariadne shows lower signaling potency and efficacy in multiple signaling pathways examined (G_q, G₁₁, and β-arrestin2) coupled to 5-HT_2A receptors. We confirmed the shift in signaling for an α-propyl analog and provide a molecular docking rationale for the progressive decrease in signaling potency with the growing length of the α-substituent. …”

Inhibiting translation in 5-HT neurons does not recapitulate a <i>Minute</i> phenotype. by Lisa Patricia Deliu (13570709)

Effect of 5-HTR blockade on the relationship between error rate and reaction time in the reward-size task. by Yukiko Hori (299784)

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HT1080 human sarcoma xenograft growth in CD-1 athymic mice and body weight comparison under therapy with intravenous (i.v.) tTF-NGR, tumor radiotherapy, and a combination of both t... by Caroline Brand (3448523)

“…<p>(A) Arrows show treatment intervention for tTF-NGR (1.5 mg/kg body weight (bw) x 5) or tumor radiotherapy (4.8 Gy x 2). …”

Expression of 5HT-2AR, 2BR, 3AR, and 3BR mRNA in the mid colon. by Ji Eun Kim (403026)

SWSs measured for cell-laden gels with 5 mg/ml Matrigel and 1 mg/ml (M5C1), 2 mg/ml (M5C2), and 3 mg/ml (M5C3) collagen type I. by Shao-Lun Lu (12360135)

Table_1_Sub-Acute Treatment of Curcumin Derivative J147 Ameliorates Depression-Like Behavior Through 5-HT1A-Mediated cAMP Signaling.DOCX by Jianxin Li (158332)

“…Background<p>Major depressive disorder (MDD) is a severe mental disorder related to the deficiency of monoamine neurotransmitters, particularly to abnormalities of 5-HT (5-hydroxytryptamine, serotonin) and its receptors. …”

Inducing proteotoxic stress in 5-HT neurons does not recapitulate a <i>Minute</i> phenotype. by Lisa Patricia Deliu (13570709)

S5 File - by Wenxin Ye (14392899)